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Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit

Year 2022, Volume: 49 Issue: 1, 66 - 76, 11.03.2022
https://doi.org/10.5798/dicletip.1086205

Abstract

References

  • 1.Kurt NG, Çamcı M. COVID-19 and Other ViralPneumonias. Dicle Tıp Dergisi / Dicle Med J. 2021;48: 40-6.
  • 2.https://coronavirus.jhu.edu/map.html (Lastaccess: 30.12.2021)
  • 3.D’Elia RV, Harrison K, Oyston PC, Lukaszewski RA,Clark GC. Targeting the ‘cytokine storm’ fortherapeutic benefit. Clin Vaccine Immunol. 2013; 20:319–27.
  • 4.Ramos-Casals M, Brito-Zeron P, Lopez-GuillermoA, Khamashta MA, Bosch X. Adult haemophagocyticsyndrome. Lancet. 2014; 383(9927): 1503-16.

Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit

Year 2022, Volume: 49 Issue: 1, 66 - 76, 11.03.2022
https://doi.org/10.5798/dicletip.1086205

Abstract

Objective: The novel coronavirus, called SARS-CoV-2, causes COVID-19 disease and began a pandemic on a global scale. Uncontrolled cytokine production is observed especially in COVID-19 cases with severe progression and this situation is thought to be one of the causes of more severe disease progression and increased mortality.
In our study, we aimed to assess the efficacy of Coupled Plasma Filtration Adsorption (CPFA) treatment in situations with severe disease progression like sepsis, septic shock and multiple organ failure, considered to be secondary to cytokine storm, in COVID-19 disease.
Methods: Our study retrospectively screened data from 20 patients admitted to our intensive care unit and administered CPFA. CPFA was administered as 10 hours each session and 2 sessions with 12 hours interval.
Results: After our CPFA treatment, there were statistically significant ameliorations in clinical and laboratory findings like SOFA scores, mainly, Horowitz values, fever and IL-6 values.
Conclusion: The CPFA treatment removes the uncontrolled production of harmful cytokines/chemokines and toxic substances from the blood and shows promise in the treatment of the cytokine storm that develops in COVID-19 disease.

References

  • 1.Kurt NG, Çamcı M. COVID-19 and Other ViralPneumonias. Dicle Tıp Dergisi / Dicle Med J. 2021;48: 40-6.
  • 2.https://coronavirus.jhu.edu/map.html (Lastaccess: 30.12.2021)
  • 3.D’Elia RV, Harrison K, Oyston PC, Lukaszewski RA,Clark GC. Targeting the ‘cytokine storm’ fortherapeutic benefit. Clin Vaccine Immunol. 2013; 20:319–27.
  • 4.Ramos-Casals M, Brito-Zeron P, Lopez-GuillermoA, Khamashta MA, Bosch X. Adult haemophagocyticsyndrome. Lancet. 2014; 383(9927): 1503-16.
There are 4 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Tuna Ertürk This is me

Bülent Barış Güven This is me

Gülten Kevser Ünlükahraman This is me

Ayşın Ersoy This is me

Publication Date March 11, 2022
Submission Date August 24, 2021
Published in Issue Year 2022 Volume: 49 Issue: 1

Cite

APA Ertürk, T., Güven, B. B., Ünlükahraman, G. K., Ersoy, A. (2022). Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit. Dicle Tıp Dergisi, 49(1), 66-76. https://doi.org/10.5798/dicletip.1086205
AMA Ertürk T, Güven BB, Ünlükahraman GK, Ersoy A. Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit. diclemedj. March 2022;49(1):66-76. doi:10.5798/dicletip.1086205
Chicago Ertürk, Tuna, Bülent Barış Güven, Gülten Kevser Ünlükahraman, and Ayşın Ersoy. “Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit”. Dicle Tıp Dergisi 49, no. 1 (March 2022): 66-76. https://doi.org/10.5798/dicletip.1086205.
EndNote Ertürk T, Güven BB, Ünlükahraman GK, Ersoy A (March 1, 2022) Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit. Dicle Tıp Dergisi 49 1 66–76.
IEEE T. Ertürk, B. B. Güven, G. K. Ünlükahraman, and A. Ersoy, “Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit”, diclemedj, vol. 49, no. 1, pp. 66–76, 2022, doi: 10.5798/dicletip.1086205.
ISNAD Ertürk, Tuna et al. “Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit”. Dicle Tıp Dergisi 49/1 (March 2022), 66-76. https://doi.org/10.5798/dicletip.1086205.
JAMA Ertürk T, Güven BB, Ünlükahraman GK, Ersoy A. Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit. diclemedj. 2022;49:66–76.
MLA Ertürk, Tuna et al. “Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit”. Dicle Tıp Dergisi, vol. 49, no. 1, 2022, pp. 66-76, doi:10.5798/dicletip.1086205.
Vancouver Ertürk T, Güven BB, Ünlükahraman GK, Ersoy A. Results of Coupled Plasma Filtration Adsorption (CPFA) Treatment Applied to Critical COVID-19 Patients in Intensive Care Unit. diclemedj. 2022;49(1):66-7.