Admission Serum Creatinine/Albumin Ratio and its Relationship with 1-Year Mortality in Decompensated Heart Failure Patients

Year 2024, Volume: 51 Issue: 2, 223 - 231, 14.06.2024

Mehmet Ali Işık , Adem Aktan , Tuncay Güzel , Raif Kılıç , Muhammed Demir , Serhat Günlü , Fethullah Kayan Mehmet Zülkif Karahan , Mehmet Özbek , Abdulkadir Arpa , Nihat Polat Murat Yüksel

https://doi.org/10.5798/dicletip.1501288

Abstract

Aim: Despite medical advancements, heart failure (HF) maintains high mortality rates. Our research delves into examining the relationship between the serum creatinine/albumin ratio and one-year mortality in patients with decompensated systolic HF.
Methods: During the period from October 2014 to October 2015, we enrolled 80 patients (comprising 37 females) who had been diagnosed with acute systolic decompensated heart failure and had a left ventricular ejection fraction (LVEF) of ≤ 40%. These patients were divided into two cohorts depending on whether they experienced all-cause mortality within the span of one year.
Results: Among the 80 participants, 31 (39%) experienced mortality within the first year. The average age of the deceased group was 69±14 years, with 38.7% (n=12) being female. In contrast, the surviving group had an average age of 66±12 years, with 51% (n=25) being female. The HF group with mortality exhibited significantly higher levels of serum creatinine-albumin ratio, urea, and creatinine values, along with a higher prevalence of pretibial edema (p<0.01).Furthermore, the deceased HF group exhibited significantly lower LVEF, albumin levels, lymphocyte counts, and systolic and diastolic blood pressure values. Statistical analysis revealed a significant difference in the serum creatinine/albumin ratio between the deceased group (0.68±0.27) and the surviving group (0.38±0.18), with a p-value of less than 0.01. Using a cut-off value of 0.45 for the creatinine/albumin ratio, the sensitivity and specificity for predicting one-year mortality in HF patients were 81% and 78% , respectively.
Conclusion: The conjunction of heightened creatinine levels, diminished albumin levels, and an augmented creatinine/albumin ratio could potentially function as straightforward, economical prognostic indicators for forecasting one-year mortality in systolic decompensated HF patients.

Keywords

Albumin, creatinine/albumin ratio, creatinine, heart failure, mortality

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