Selenyumun Çocuk Gelişimindeki Rolüne İlişkin Küresel Araştırma Trendleri ve Gelecekteki Yönlendirmeler: Bibliyometrik Analiz

Year 2025, Issue: Early Access

Gulnara Batyrova , Gulaim Taskozhina , Gulmira Umarova , Yeskendir Umarov

https://doi.org/10.18678/dtfd.1711470

Abstract

Amaç: Selenyum, çocukların büyümesi ve gelişimini önemli ölçüde etkileyen, insan vücudu için gerekli temel bir eser elementtir. Bu çalışmanın amacı, selenyumun çocuk gelişimi üzerindeki etkisini incelemek, ortaya çıkan kavramları analiz etmek ve gelecekteki eğilimleri öngörmektir.
Gereç ve Yöntemler: Scopus Web of Science Core Collection veri tabanlarında kapsamlı arama stratejileri kullanılarak 155 İngilizce makale belirlenmiştir. Yayınlar, atıflar, önde gelen yazarlar, iş birliği ağları ve etkili dergiler, Biblioshiny ve Bibliometrics R araçları kullanılarak analiz edilmiştir.
Bulgular: Son 51 yılda yapılan yayınlar ve araştırma bulguları, selenyumun çocuk gelişimi ve büyümesi üzerindeki olumlu etkilerine ilişkin farkındalığın arttığını göstererek istikrarlı bir büyüme eğilimi göstermektedir. Amerika Birleşik Devletleri ve Çin, başlıca katkı sağlayan ülkeler olarak öne çıkmıştır. Pekin Üniversitesi, Charité - Universitätsmedizin Berlin ve Humboldt Üniversitesi önde gelen kurumlar olurken, Skalny A. ve Chen J. en üretken yazarlar olarak belirlenmiştir. Biological Trace Element Research dergisi, bu alandaki bilginin yaygınlaştırılmasında önde gelen dergi olarak ortaya çıkmıştır. Ayrıca, anahtar kelime analizi “selenium”, “insan” ve “çocuk” gibi terimlerin önemini ortaya koymuştur. Genel olarak, selenyum ve çocuk büyümesiyle ilişkisi üzerine küresel bir iş birliğinin ürünü olan bu kapsamlı çalışma, selenyum hakkında derinlemesine bir çalışma sunmaktadır.
Sonuç: Bu analizin sonuçları, gelecekteki araştırma önceliklerini ve bu alanda devam eden araştırmalara duyulan ihtiyacı vurgulayarak selenyumun çocuk gelişimi ve sağlığı üzerindeki mekanizmalarını ve daha geniş etkilerini daha fazla incelemek için disiplinler arası araştırmaların genişletilmesini savunmaktadır.

Keywords

Bibliyometri , selenyum , çocuk gelişimi , büyüme , çocuklar

Global Research Trends and Future Directions in Selenium's Role in Child Development: A Bibliometric Analysis

Abstract

Aim: Selenium is an essential trace element for the human body, which significantly affects the growth and development of children. This study aimed to investigate the effects of selenium on child development, analyze emerging concepts, and predict future trends.
Material and Methods: Using comprehensive search strategies in the Scopus and Web of Science Core Collection databases, 155 articles in English were identified. Publications, citations, prominent authors, collaboration networks, and influential journals were analyzed using the tools Biblioshiny and Bibliometrics R.
Results: A steady growth trajectory was shown, with publications and research findings over the past 51 years demonstrating an increasing awareness of the positive effects of selenium on child development and growth. The United States and China were identified as the leading contributors. Peking University, Charité - Universitätsmedizin Berlin, and Humboldt University were the leading institutions, with Skalny A. and Chen J. identified as the most prolific authors. Biological Trace Element Research has emerged as the leading journal for disseminating knowledge in this field. In addition, keyword analysis revealed the importance of terms such as “selenium,” “human,” and “child.” Overall, this comprehensive study, the product of a global collaboration on selenium and its relationship to child growth, provides an in-depth study of selenium.
Conclusion: The results of this analysis highlight future research priorities and the need for continued research in this area, advocating for expanded interdisciplinary studies to further explore the mechanisms and broader effects of selenium on child development and health.

Keywords

Bibliometrics , selenium , child development , growth , children

References

• Shahidin, Wang Y, Wu Y, Chen T, Wu X, Yuan W, et al. Selenium and selenoproteins: mechanisms, health functions, and emerging applications. Molecules. 2025;30(3):437.
• An X, Yu W, Liu J, Tang D, Yang L, Chen X. Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis. 2024;15(8):556.
• Ojeda ML, Nogales F, Romero-Herrera I, Carreras O. Fetal programming is deeply related to maternal selenium status and oxidative balance; experimental offspring health repercussions. Nutrients. 2021;13(6):2085.
• Dobrzyńska M, Kaczmarek K, Przysławski J, Drzymała-Czyż S. Selenium in infants and preschool children nutrition: a literature review. Nutrients. 2023;15(21):4668.
• Batyrova G, Taskozhina G, Umarova G, Umarov Y, Morenko M, Iriskulov B, et al. Unveiling the role of selenium in child development: impacts on growth, neurodevelopment and immunity. J Clin Med. 2025;14(4):1274.
• Ning Y, Hu M, Chen S, Zhang F, Yang X, Zhang Q, et al. Investigation of selenium nutritional status and dietary pattern among children in Kashin-Beck disease endemic areas in Shaanxi Province, China using duplicate portion sampling method. Environ Int. 2022;164:107255.
• Chen Z, Li H, Yang L, Wang W, Li Y, Gong H, et al. Hair selenium levels of school children in Kashin-Beck disease endemic areas in Tibet, China. Biol Trace Elem Res. 2015;168(1):25-32.
• Yang Y, Zhang R, Deji Y, Li Y, Li Y. Geographical patterns and determinants of selenium deficiency in Tibet: A cross-sectional study based on urinary selenium analysis. Earth's Future. 2025;13:e2024EF005748.
• Wu Y, Cai T, Tao Y, Zhao J, Zhang J. Emerging insights and global trends in the relationship between selenium and thyroid diseases: a bibliometric analysis. Endocr Metab Immune Disord Drug Targets. 2024;24(7):808-19.
• Abejón R. A bibliometric analysis of research on selenium in drinking water during the 1990-2021 period: treatment options for selenium removal. Int J Environ Res Public Health. 2022;19(10):5834.
• Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369(9555):60-70.
• Sudfeld CR, McCoy DC, Danaei G, Fink G, Ezzati M, Andrews KG, et al. Linear growth and child development in low- and middle-income countries: a meta-analysis. Pediatrics. 2015;135(5):e1266-75.
• Upadhyay RP, Pathak BG, Raut SV, Kumar D, Singh D, Sudfeld CR, et al. Linear growth beyond 24 months and child neurodevelopment in low- and middle-income countries: a systematic review and meta-analysis. BMC Pediatr. 2024;24(1):101.
• Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development. Am J Clin Nutr. 2007;86(2):412-20.
• Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, et al. Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab. 2015;100(11):4037-47.
• Zuo XL, Chen JM, Zhou X, Li XZ, Mei GY. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biol Trace Elem Res. 2006;114(1-3):41-53.
• Chin SE, Shepherd RW, Thomas BJ, Cleghorn GJ, Patrick MK, Wilcox JA, et al. The nature of malnutrition in children with end-stage liver disease awaiting orthotopic liver transplantation. Am J Clin Nutr. 1992;56(1):164-8.
• Di Cosmo C, McLellan N, Liao XH, Khanna KK, Weiss RE, Papp L, et al. Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X). J Clin Endocrinol Metab. 2009;94(10):4003-9.
• Kavanaugh-McHugh AL, Ruff A, Perlman E, Hutton N, Modlin J, Rowe S. Selenium deficiency and cardiomyopathy in acquired immunodeficiency syndrome. JPEN J Parenter Enteral Nutr. 1991;15(3):347-9.
• Hu X, Zheng T, Cheng Y, Holford T, Lin S, Leaderer B, et al. Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China. J Reprod Med. 2015;60(1-2):21-9.
• Reeves WC, Marcuard SP, Willis SE, Movahed A. Reversible cardiomyopathy due to selenium deficiency. JPEN J Parenter Enteral Nutr. 1989;13(6):663-5.
• Ellis JM, Tan HK, Gilbert RE, Muller DP, Henley W, Moy R, et al. Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial. BMJ. 2008;336(7644):594-7.
• López-Sobaler AM, Aparicio A, González-Rodríguez LG, Cuadrado-Soto E, Rubio J, Marcos V, et al. Adequacy of usual vitamin and mineral intake in Spanish children and adolescents: ENALIA study. Nutrients. 2017;9(2):131.
• Ahamed M, Siddiqui MK. Environmental lead toxicity and nutritional factors. Clin Nutr. 2007;26(4):400-8.
• Golden MH. Proposed recommended nutrient densities for moderately malnourished children. Food Nutr Bull. 2009;30(3 Suppl):S267-342.
• European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific opinion on dietary reference values for selenium. EFSA Journal. 2014;12(10):3846.
• Oh C, Keats EC, Bhutta ZA. Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: a systematic review and meta-analysis. Nutrients. 2020;12(2):491.
• Bedwal RS, Nair N, Sharma MP, Mathur RS. Selenium--its biological perspectives. Med Hypotheses. 1993;41(2):150-9.
• Köhrle J. Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes. 2013;20(5):441-8.
• Lewicka I, Kocyłowski R, Grzesiak M, Gaj Z, Oszukowski P, Suliburska J. Selected trace elements concentrations in pregnancy and their possible role - literature review. Ginekol Pol. 2017;88(9):509-14.
• Yakoob MY, Lo CW. Nutrition (micronutrients) in child growth and development: A systematic review on current evidence, recommendations and opportunities for further research. J Dev Behav Pediatr. 2017;38(8):665-79.
• Neve J. Clinical implications of trace elements in endocrinology. Biol Trace Elem Res. 1992;32:173-85.
• Wong T. Parenteral trace elements in children: clinical aspects and dosage recommendations. Curr Opin Clin Nutr Metab Care. 2012;15(6):649-56.
• Yan L, Zhiping W. Mapping the literature on academic publishing: a bibliometric analysis on WOS. Sage Open. 2023;13(1):21582440231158562.
• Solé-Navais P, Brantsæter AL, Caspersen IH, Lundh T, Muglia LJ, Meltzer HM, et al. Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the Norwegian mother, father and child cohort study. Nutrients. 2020;13(1):23.
• Wang X, Li H, Yang L, Kong C, Wang J, Li Y. Selenium nutritional status of rural residents and its correlation with dietary intake patterns in a typical low-selenium area in China. Nutrients. 2020;12(12):3816.
• Fábelová L, Vandentorren S, Vuillermoz C, Garnier R, Lioret S, Botton J. Hair concentration of trace elements and growth in homeless children aged <6years: Results from the ENFAMS study. Environ Int. 2018;114:318-25.
• Demircan K, Chillon TS, Jensen RC, Jensen TK, Sun Q, Bonnema SJ, et al. Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: The Odense Child Cohort. Free Radic Biol Med. 2024;220:324-32.
• Skröder HM, Hamadani JD, Tofail F, Persson LÅ, Vahter ME, Kippler MJ. Selenium status in pregnancy influences children's cognitive function at 1.5 years of age. Clin Nutr. 2015;34(5):923-30.
• Bizerea-Moga TO, Pitulice L, Bizerea-Spiridon O, Angelescu C, Mărginean O, Moga TV. Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology. Front Pediatr. 2023;11:1157689.
• Schneegans S, Straza T, Lewis J, editors. UNESCO science report: The race against time for smarter development. Paris: UNESCO Publishing; 2021.
• Kieliszek M, Bano I, Zare H. A comprehensive review on selenium and its effects on human health and distribution in Middle Eastern countries. Biol Trace Elem Res. 2022;200(3):971-87.