Association between Mammographic Breast Density and Markers of Calcium Metabolism in Women: A Retrospective Observational Study

Year 2025, Issue: Early Access

Eren Çamur , Yasin Celal Güneş , Yusuf Öztürk , Berkay Ersöz , Cenkgazi Karabıyıkoğlu Seçil Gündoğdu Betül Akdal Dölek

https://doi.org/10.18678/dtfd.1719914

Abstract

Aim: The aim of this study was to assess the relationship between mammographic breast density and biochemical indices of calcium metabolism, as well as femoral neck bone mineral density (BMD) in women aged 40-80 years.
Material and Methods: In this retrospective, single-center study, 598 women undergoing screening mammography between November 2020 and March 2025 were included. After applying exclusion criteria, 200 age-matched women were randomly selected and evenly stratified into four BI-RADS breast composition categories (A, B, C, and D), 50 women in each. Serum vitamin D3, parathyroid hormone (PTH), calcium, and femoral neck t-scores were retrieved from institutional records and compared between these four categories.
Results: Vitamin D3 levels (p=0.021) and femoral neck t-scores (p=0.041) were found to be significantly different between four categories. Post hoc analysis demonstrated significantly different vitamin D3 concentrations in the Category D compared with categories A (p=0.021), B (p=0.032), and C (p=0.048). Femoral neck t-scores progressively decreased in Category D compared to categories A (p=0.013), B (p=0.025), and C (p=0.041). No significant differences were observed for PTH (p=0.589) or serum calcium (p=0.441).
Conclusion: Higher mammographic breast density was associated with lower vitamin D3 concentrations and reduced femoral neck BMD. Breast composition may serve as a readily available imaging biomarker to identify women at increased risk of vitamin D deficiency and osteoporosis, and has potential integration into individualized risk stratification strategies.

Keywords

Mammography , density , calcium , metabolism , osteoporosis

Kadınlarda Mamografik Meme Dansitesi ile Kalsiyum Metabolizması Belirteçleri Arasındaki İlişki: Retrospektif Gözlemsel Çalışma

Abstract

Amaç: Bu çalışmanın amacı, 40-80 yaş arası kadınlarda mamografi meme yoğunluğu ile kalsiyum metabolizmasının biyokimyasal göstergeleri ve femur boynu kemik mineral yoğunluğu (KMY) arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntemler: Bu retrospektif, tek merkezli çalışmaya, Kasım 2020 ile Mart 2025 tarihleri arasında tarama mamografisi çekilen 598 kadın dahil edildi. Dışlama kriterleri uygulandıktan sonra, yaşları eşleştirilmiş 200 kadın rastgele seçildi ve her birinde 50 kadın olacak şekilde dört BI-RADS meme kompozisyon kategorisine (A, B, C ve D) eşit şekilde ayrıldı. Serum vitamin D3, paratiroid hormonu (PTH), kalsiyum ve femur boynu t-skorları kurumsal kayıtlardan alındı ve bu dört kategori arasında karşılaştırıldı.
Bulgular: Vitamin D3 düzeyleri (p=0,021) ve femur boynu t-skorlarının (p=0,041) dört kategori arasında anlamlı derecede farklı olduğu bulundu. Post-hoc analiz, D kategorisinde, vitamin D3 konsantrasyonlarının A (p=0,021), B (p=0,032) ve C (p=0,048) kategorilerine kıyasla anlamlı derecede farklı olduğunu gösterdi. Femur boynu t-skorları ise D kategorisinde A (p=0,013), B (p=0,025) ve C (p=0,041) kategorilerine kıyasla giderek azaldı. PTH (p=0,589) veya serum kalsiyumu (p=0,441) için anlamlı bir fark gözlenmedi.
Sonuç: Daha yüksek mamografi meme yoğunluğu, daha düşük D3 vitamini konsantrasyonları ve azalmış femur boynu KMY ile ilişkiliydi. Meme kompozisyonu, D vitamini eksikliği ve osteoporoz riski yüksek kadınları belirlemek için kolayca bulunabilen bir görüntüleme biyobelirteci olarak kullanılabilir ve bireyselleştirilmiş risk sınıflandırma stratejilerine entegre olma potansiyeline sahiptir.

Keywords

Mamografi , dansite , kalsiyum , metabolizma , osteoporoz

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