Mucous Membrane Pemphygoid A Case Report

Year 2010, Volume: 37 Issue: 1 - Volume: 37 Issue: 1, 45 - 50, 01.05.2010

Asriye Mocan Elvan Pala İbrahim Kılıç

Abstract

Mucous membrane pemphigoid MMP is an otoimmun, cronic, inflamatuary, blastering disease. Its clinical presentation may cover the oral mucosa, the ocular mucosa, the other mucous membrane and the skin. Healing of the lesions, except the lesions of oral mucosa, occurs with skar tissue which may cause blindness when involves the conjuctiva. Ocular mucosa is the most involved mucousa after oral mucosa. Ophtalmologic consultation and following up of this patients is necessary. A multidisciplinary approach is essential in the managenet of MMP. Early recognition and treatment may decrease disease-related complications. Patients who have disease occuring in only oral mucosa are defined as “low risk” patients. Nowadays, low group patients can be controlled by topical corticosteroids TC , which have proved to be highly efficient and to cause fewer adverse effects compared with systemic corticosteroids. The effect of TC depends on its potency, concentration, pharmaceutical form and contact time between the drug and lesion. The medical status of the patient, the severity of the oral lesions, the extensiveness of the lesion and the experience of the clinician affect the choice of the special formulation, treatment regime and the potency of TCs which will be used in treatment of MMP limited in the oral mucosa. In this report clinical view of a 59 years old female patient with MMP who is treated with corticosteroids is presented

Keywords

mucous membrane pemphygoid, topical corticosteroids, oral mucosa

Mükoz membran pemfigoidi – bir olgu sunumu

Abstract

Mükoz membran pemfigoid MMP kronik, enflamatuar, subepiteliyal veziküllo-büllöz bir otoimmün hastalıktır. Hastalığın lezyonları oral mukozayı, oküler mukozayı,diğer muköz membranları ve deriyi kapsayabilir. Ağız lezyonların haricindeki lezyonların iyileşmesi skarla sonuçlanır. Göz tutulumu körlükle sonuçlanabilir. Oral mukozadan sonra en sık tutulan bölge konjuktiva olduğu için bu hastalarda mutlaka oftalmolojik konsültasyon ve takip yapılmalıdır. MMP’in tedavisi multdisipliner bir yaklaşım gerektirir. Erken teşhis ve tedavisi hastalığa bağlı komplikasyonları önleyebilir. Lezyonları sadece ağız içinde olan hastalar “düşük riskli” hasta grubu olarak tanımlanır. Günümüzde düşük riskli hasta grubu sistemik kortikosteroidlere göre daha etkili ve daha az yan etkileri olan topikal kortikosteroidlerle tedavi edilebilir. TS’lerin etkinliği ilacın gücüne, konsantrasyonuna, ilacın farmasötik şekline ve ilaç – lezyon temas süresine bağlıdır. Hastanın medikal durumu, ağız içi lezyonların şiddeti, tutulumun yaygınlığı ve hekimin deneyimi oral mukozada sınırlı kalan MMP’nin tedavisinde kullanılacak TS’nin potensinin, özel formülasyonun ve tedavi rejiminin seçimini etkiler. Bu raporda 59 yaşında MMP’li bir kadın hastanın kliniği ve topikal steroidlerle yapılan tedavisi sunulmaktadır.

Keywords

muköz membran pemfigoidi, topikal kortikosteroidler, oral mukoza

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