A 90-day study was undertaken to evaluate the effects of Stachytarpheta jamaicensis and Garciniakola seed meal on the growth and gonad development of the African catfish, Clarias gariepinus. Ninety(90) fingerlings were stocked in nine rectangular concrete tanks (10 each)labeled Al, A2, A3, Bl, B2,B3, C1, C2 and C3 with a totalwater volume of 887.04 m3.Three isonitrogenous diets (A, B, and C)with 40% crude protein including the control diet containing 0g of S. jamaicensis and 0g of G. kola meal, 70 of S. jamaicensis leaf meal and 35g of G. kolameal + 35g of S.jamaicensisleaf meal in the feed were fed to the fish at 5% body weight.Fish in A-series tanks were fed diet A, fish in B-series tanks were fed diet Bwhile fish in C-series tanks were fed diet C. Weight gain, length gain, SGR,GR, and FCR were better in fish fed the diet A but not significantly different(P>0.05) from fish fed diet B and diet C. Female GSI, male and female gonad weight were better infish fed diet A but not significantly different (P>0.05) from fish fed dietB and diet C. However, male GSI (1.39 ± 0.01) of fish fed the diet A wassignificantly different (P<0.05) from male fish fed diet B (0.94 ± 0.15) anddiet C (0.95 ± 0.05). Fecundity of fish fed diet A (11,834 ± 1644eggs) wassignificantly different (P<0.05) from fish fed diet B (6375 ± 995eggs) anddiet C (10,236 ± 896eggs). Histology of ovaries and testes of fish fed thethree experimental diets showed normal distribution of oocytes and testicularcells. Our findings imply that the combination of G. kola seed meal and S.jamaicensis leaf meal in feednegatively affects the growth, fecundity, and gonad development of C.gariepinuswhich can be detrimental toaquaculture production.