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<article  article-type="reviewer-report"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>egejfas</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Ege Journal of Fisheries and Aquatic Sciences</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2148-3140</issn>
                                                                                            <publisher>
                    <publisher-name>Ege University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.12714/egejfas.38.1.15</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Structural Biology</subject>
                                                            <subject>Chemical Engineering</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Yapısal Biyoloji </subject>
                                                            <subject>Kimya Mühendisliği</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Trends in a natural product fucoxanthin</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>Doğal ürün fukoksantin trendleri</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Aslanbay</surname>
                                    <given-names>Bahar</given-names>
                                </name>
                                                                    <aff>EGE ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, BİYOMÜHENDİSLİK BÖLÜMÜ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-8759-7388</contrib-id>
                                                                <name>
                                    <surname>İmamoğlu</surname>
                                    <given-names>Esra</given-names>
                                </name>
                                                                    <aff>EGE ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, BİYOMÜHENDİSLİK BÖLÜMÜ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20210315">
                    <day>03</day>
                    <month>15</month>
                    <year>2021</year>
                </pub-date>
                                        <volume>38</volume>
                                        <issue>1</issue>
                                        <fpage>117</fpage>
                                        <lpage>124</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20200218">
                        <day>02</day>
                        <month>18</month>
                        <year>2020</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20200617">
                        <day>06</day>
                        <month>17</month>
                        <year>2020</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 1984, Ege Journal of Fisheries and Aquatic Sciences</copyright-statement>
                    <copyright-year>1984</copyright-year>
                    <copyright-holder>Ege Journal of Fisheries and Aquatic Sciences</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>Fucoxanthin is a xanthophyll pigment which occurs in marine brown seaweeds (macroalgae), diatoms and several microalgae species. It forms with chlorophyll a-c and several proteins, a major fucoxanthin-chlorophyll a/c complex, which transfers light energy to the photosynthesis center and plays a major role in light harvesting. Recent studies have reported that fucoxanthin has many physiological functions and biological effects, such as anti-obesity, antidiabetic, anti-inflammatory, anticancer and cardiovascular system protection.  Therefore, this pigment is highly preferred for the prevention and treatment of various chronic diseases. In addition, potential applications of high value fucoxanthin can be found in cosmetic, food and feed industries. In this review paper, the historical development, characteristic properties and possible sources of fucoxanthin are extensively described. The potential biological activities of fucoxanthin are also discussed. Finally, brief overview of common applications and market analysis of commercial fucoxanthin are also reported.</p></trans-abstract>
                                                                                                                                    <abstract><p>Fukoksantin, ksantofil grubuna ait karotenoidlerden biri olup yaygın olarak kahverengi deniz yosunlarında (makroalgler), diatomlarda ve birkaç mikroalg türünde bulunmaktadır. Fukoksantin pigmenti, alglerde klorofil ve protein ile birlikte kompleks bir yapı oluşturarak ışığın toplanmasında ve fotosentez merkezine gönderilmesinde önemli bir rol almaktadır. Son yıllarda yapılan araştırmalar sonucunda fukoksantinin hayvanlar üzerinde antiobezite, antidiyabet, antienflamatuvar, antikanser ve kardiyovasküler sistemi koruma gibi olumlu etkilere sahip olduğu görülmüştür. Bu nedenle kronik hastalıkların önlenmesinde ve tedavisinde fukoksantinin etken madde olarak kullanımına dair çalışmalar sürdürülmektedir. Ayrıca kozmetik, gıda ve yem sektörlerinde de fukoksantin bileşiğinin kullanım potansiyeli değerlendirilmektedir. Bu makalede fukoksantin karotenoidinin genel özelliklerinden, tarihsel gelişiminden ve mevcut kaynaklarından bahsedilmiş, hayvanlar üzerindeki potansiyel biyolojik aktiviteleri incelenmiş ve kullanım alanları ile birlikte piyasadaki durumu ortaya konmuştur.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Fukoksantin</kwd>
                                                    <kwd>  Ksantofil</kwd>
                                                    <kwd>  Karotenoid</kwd>
                                                    <kwd>  Algal biyoteknoloji</kwd>
                                                    <kwd>  Doğal ürün</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>Fucoxanthin</kwd>
                                                    <kwd>  Xanthophyll</kwd>
                                                    <kwd>  Carotenoid</kwd>
                                                    <kwd>  Algal biotechnology</kwd>
                                                    <kwd>  Natural product</kwd>
                                            </kwd-group>
                                                                                                                                    <funding-group specific-use="FundRef">
                    <award-group>
                                                    <funding-source>
                                <named-content content-type="funder_name">TUBİTAK</named-content>
                            </funding-source>
                                                                            <award-id>115M014</award-id>
                                            </award-group>
                </funding-group>
                                </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Abu-Ghannam, N. &amp; Shannon, E. (2017). Seaweed Carotenoid, Fucoxanthin, as Functional Food, in V. K. Gupta, H. Treichel, V. Shapaval, L. Antonio de Oliveira and M. G. Tuohy (Eds.), Microbial Functional Foods and Nutraceuticals, John Wiley &amp; Sons, Ltd, Chichester, UK.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Airanthi, M.K.W., Hosokawa, M. &amp; Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. &amp; Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of  Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. &amp; Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. &amp; Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. &amp; Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. &amp; Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Dittami, S.M., Michel, G., Collen, J., Boyen, C. &amp; Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Englert, G., Bjornland, T. &amp; Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Gammone, M.A. &amp; D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Gammone, M.A., Riccioni, G. &amp; D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Garama, D., Bremer, P. &amp; Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. &amp; Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. 
Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Irvani, N., Hajiaghaee, R. &amp; Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. &amp; Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography &amp; Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Joel, J. (2016). Global fucoxanthin market 2016 industry trends, sales, supply, demand, analysis and forecast to 2021, Analysis and Forecast. New York.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Joshi, S., Kumari, R. &amp; Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. &amp; Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. &amp; Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Kumar, S.R., Hosokawa, M. &amp; Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Lu, X., Liu, B., He, Y., Guo, B., Sun, H. &amp; Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. &amp; Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food &amp; Function, 10, 7333.	
DOI: 10.1039/c9fo01364d</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Mise, T., Ueda, M. &amp; Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Mohamadnia, S., Tavakoli, O., Faramrzi M.A. &amp; Shamsollahi, Z. (2020).  Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637.	
DOI: 10.1016/j.aquaculture.2019.734637</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Nahar, M., Hasan, W., Rajak, R. &amp; Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Oryza Oil &amp; Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Páduaa, D., Rochaa, E., Gargiuloa, D. &amp; Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">Peng, J., Yuan, J.P., Wu, C.F. &amp; Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. &amp; Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. &amp; Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">Quitain, A.T., Kai, T., Sasaki, M. &amp; Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797.	
DOI: 10.1021/jf400740p</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">Rajauria, G., Foley, B. &amp; Abu-Ghannama, N. (2017). Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed. Food Research International, 99(3): 995-1001. DOI: 10.1016/j.foodres.2016.09.023</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">Raposo, M.F.J., Morais, A.M.M.B. &amp; Morais, R.M.S.C. (2015). Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases. Marine Drugs, 13, 5128-5155.	
DOI: 10.3390/md13085128</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">Sahin, M.S., Khazi, M.I., Demirel, Z. &amp; Conk Dalay, M. (2019). Variation in growth, fucoxanthin, fatty acids profile and lipid content of marine diatoms Nitzschia sp. and Nanofrustulum shiloi in response to nitrogen and iron. Biocatalysis and Agricultural Biotechnology, 19, 390-398. DOI: 10.1016/j.bcab.2018.12.023</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">Sakai, S., Sugawara, T. &amp; Hirata, T. (2011). Inhibitory effect of dietary carotenoids on dinitrofluorobenzene-induced contact hypersensitivity in mice. Bioscience, Biotechnology and Biochemistry, 75, 1013 – 1015. DOI: 10.1271/bbb.110104</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">Sangeetha, R.K., Bhaskar, N., Divakar, S. &amp; Baskaran, V. (2010). Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI). Molecular and Cellular Biochemistry, 333: 299–310. DOI: 10.1007/s11010-009-0231-1</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">Susanto, E., Fahmi, A.S., Abeb, M., Hosokawa, M. &amp; Miyashita, K. (2016). Lipids, fatty acids, and fucoxanthin content from temperate and tropical brown seaweeds. Aquatic Procedia, 7, 66 – 75.	
DOI: 10.1016/j.aqpro.2016.07.009</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">Takahashi, K., Hosokawa, M., Kasajima, H., Hatanaka, K., Kudo, K., Shimoyama, N. &amp; Miyashita, K. (2015). Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues. Oncology Letters, 10, 1463-1467. DOI: 10.3892/ol.2015.3380</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">Urikura, I., Sugawara, T. &amp; Hirata, T. (2011). Protective effect of fucoxanthin against UVB induced skin photoaging in hairless mice. Bioscience, Biotechnology and Biochemistry, 75(4), 757-760.	
DOI: 10.1271/bbb.110040</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">Wang, H., Zhang, Y., Chen, L., Cheng, W. &amp; Liu, T. (2018). Combined production of fucoxanthin and EPA from two diatom strains Phaeodactylum tricornutum and Cylindrotheca fusiformis cultures. Bioprocess and Biosystem Engineering, 41: 1061. DOI: 10.1007/s00449-018-1935-y</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">Xia, S., Wang, K., Wan, L., Li, A., Hu, Q. &amp; Zhang, C. (2013).  Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita. Marine Drugs, 11, 2667-2681.	
DOI: 10.3390/md11072667</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">Zarekarizi, A., Hoffmann, L. &amp; Burritt, D. (2019). Approaches for the sustainable production of fucoxanthin, a xanthophyll with potential health benefits. Journal of Applied Phycology, 31(1), 281-299.	
DOI: https://doi.org/10.1007/s10811-018-1558-3</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">Zhang, H., Tang, Y., Zhang, Y., Zhang, S., Qu, J., Wang, X., Kong, R., Han, C. &amp; Liu, Z. (2015). Fucoxanthin: A promising medicinal and nutritional ingredient. Evidence-Based Complementary Alternative Medicine, 2015, 723515. DOI: 10.1155/2015/723515</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">Zhao, D., Kim, S., Pan, C. &amp; Chung, D. (2014). Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil. Food Chemistry, 145, 505–513. DOI: 10.1016/j.foodchem.2013.08.045</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
