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Tip 2 Diyabetes Mellitus Tanılı Hastalarda El Komplikasyonları ve Klinik Verilerle İlişkisi

Year 2020, Volume: 3 Issue: 2, 67 - 73, 18.08.2020
https://doi.org/10.33713/egetbd.769896

Abstract

Amaç: Tip 2 Diyabetes Mellitusun (T2DM) kronik komplikasyonlarından biri el tutulumudur. Son yıllarda ‘Diyabetik El’ ile ilgili uluslararası mecrada artmış çalışmalara rağmen ülkemizde ‘Diyabetik El’ ile ilgili yayın sayısı azdır. Biz de bu çalışmada Türkiye Cumhuriyeti İç Anadolu Bölgesi’nde üçüncü basamak bir sağlık merkezinin endokrinoloji polikliniğine başvuran T2DM tanılı hastalarda el bozukluklarının sıklığını belirlemeyi ve T2DM ilişkili klinik ve laboratuvar veriler ile arasındaki ilişkiyi araştırmayı amaçladık.
Gereç ve Yöntem: Çalışmaya üçüncü basamak bir sağlık merkezinin endokrinoloji polikliniğine başvuran T2DM tanısı almış olan, 18-65 yaş arası hastalar ardısıra alındı. Elde bozukluğa yol açan başka hastalıkları olanlar çalışmaya alınmadı. Hastaların demografik ve DM ilişkili laboratuvar ve klinik verileri kaydedildi. Mikrovasküler ve makrovasküler komplikasyonlar, hastane bilgi sisteminden ve hastalardan alınan bilgilerden elde edildi. Hastaların el muayeneleri, hastaların DM ilişkili verilerine kör bir FTR hekimi tarafından yapıldı ve diyabetik el tutulumu açısından değerledirildi.
Bulgular: Çalışmaya 86‘sı (%73.5) kadın 117 T2DM tanılı hasta alındı. Hastaların üçte ikisinde el şikayeti vardı ve yaklaşık dörtte üçünde en az bir el komplikasyonu tespit edildi. Hastalarda bulunan el komplikasyonlarının sıklık oranları şöyle idi; kısıtlı eklem hareketi sendromu: %43.6; karpal tünel sendromu: %54.7; Dupuytren kontraktürü: %13.7; tetik parmak: %7.7; sklerodaktili: %32.5; ve kompleks bölgesel ağrı sendromu: %1.7.
Sonuç: T2DM’de sık görülen komplikasyonlardan olan el tutulumu İç Anadolu Bölgesi’nde üçüncü basamak bir hastanenin takipli hastalarında neredeyse her 4 hastanın 3’ünde tespit edildi. T2DM tanılı hastalar değerlendirilirken el tutulumu açısından da değerlendirilmesi gereklidir.

Supporting Institution

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Project Number

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References

  • American Diabetes Association. Standards of medical care in diabetes-2017. Diabetes Care. 2017;40:11–24.
  • Zyluk A, Puchalski P. Hand disorders associated with diabetes: a review. Acta Orthop Belg. 2015;81:191-196.
  • Savaş S, Köroğlu BK, Koyuncuoğlu HR, Uzar E, Celik H, Tamer NM. The effects of the diabetes related soft tissue hand lesions and the reduced hand strength on functional disability of hand in type 2 diabetic patients. Diabetes Res Clin Pract. 2007;77(1):77-83.
  • Hou WH, Li CY, Chen LH, et al. Medical claims-based case-control study of temporal relationship between clinical visits for hand syndromes and subsequent diabetes diagnosis: implications for identifying patients with undiagnosed type 2 diabetes mellitus. BMJ Open. 2016;6(10):e012071.
  • Dyck PJ, Albers JW, Andersen H, et al. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011; 27: 620–628.
  • Arkkila PET, Gautier JF. Musculoskeletal disorders in diabetes mellitus: an update. Best Pract Res Clin Rheumatol. 2003;17:945–970.
  • Kirazlı Y. Diyabetik El Rehabilitasyonu. FTR Bil Der. 2011:14 Özel Sayı;7-11.
  • Ardic F, Soyupek F, Kahraman Y, Yorgancıoğlu R. The musculoskeletal complications seen in type II diabetics: predominance of hand involvement. Clin Rheumatol. 2003;22: 229–233.
  • Cederlund RI, Thomsen N, Thrainsdottir S, Eriksson KF, Sundkvist G, Dahlin LB. Hand disorders, hand function, and activities of Daily living in elderly men with type 2 diabetes. J Diabetes Complications 2009;23:32-9.
  • Duyur Çakıt B, Özeri Z, Saraçoğlu M, Erdem HR. Diyabetes Mellituslu Hastalarda El ve Omuzu İlgilendiren Kas-İskelet Sistemi Komplikasyonları ve El Fonksiyonlarının Değerlendirilmesi. FTR Bil Der. 2009;12:99-103.
  • Ramchurn N, Mashamba C, Leitch E, et al. Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes. Eur J Intern Med 2009; 20:718.
  • Lebiedz-Odrbina D, Kay J. Rheumatic Manifestations of Diabetes Mellitus. Rheum Dis Clin N Am 2010;36:681–699.
  • Chammas M, Bousquet P, Renard E, Poirier JL, Jaffiol C & Allieu Y. Dupuytren's disease, carpal tunnel syndrome, trigger finger and diabetes mellitus. Journal of Hand Surgery, 20A:1995;109−114.
  • Comi G, Lozza L, Galardi G, et al. Prevalence of carpal tunnel syndrome in diabetics: Effects of age, sex diabetes duration and polyneuropathy. Acta Diabetologica Latina, 22:1985;259−262.
  • Becker J, Nora DB, Gomes I, et al. An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome. Clin Neurophysiol. 2002;113(9):1429–34.
  • Taşpınar Ş. Diyabetik Karpal Tünel Sendromunda Kortikosteroid Enjeksiyonu, Gece Ateli ve Fizik Tedavinin Etkinliğinin Karşılaştırılması (Uzmanlık Tezi). İstanbul:2005.
  • Comi G, Lozza L, Galardi G, et al. Prevalence of carpal tunnel syndrome in diabetics: Effects of age, sex diabetes duration and polyneuropathy. Acta Diabetologica Latina. 22:1985;259−262.
  • Gamstedt A, Holm-Glad J, Ohlson CG & Sundstrom M. Hand abnormalities are strongly associated with the duration of diabetes mellitus. Journal of Internal Medicine. 1993;234,189−193.
  • Alp R, Türk Börü Ü, Sargın H. : Tip 2 Diyabetlilerde Semptomatik Karpal Tünel Sendromu. Turkish J. Endocrinology and Metabolism. Vol. 7, No. 1, 2003.
  • Noble J, Heathcote JG & Cohen H. Diabetes mellitus in the aetiology of Dupuytren’s disease. Journal of Bone and Joint Surgery (Br) 1984; 66: 322–325.
  • Seibold JR. Digital sclerosis in children with insulin-dependent diabetes mellitus. Arthritis Rheum. 1982; 25:1357.

Hand Complications and Its Relationship with Clinic Data in Patients with Type 2 Diabetes Mellitus

Year 2020, Volume: 3 Issue: 2, 67 - 73, 18.08.2020
https://doi.org/10.33713/egetbd.769896

Abstract

Objective: Hand involvement is one of the chronic complications of the type 2 diabetes mellitus (T2DM). Despite the increasing studies in international literatures about 'Diabetic Hand' in recent years, there are only a few studies on 'Diabetic Hand' in our country. We aimed in this study that, to determine the prevalence of hand disorders in patients with T2DM who admitted to a tertiary hospital’s endocrinology outpatient clinic in Central Anatolian Region of Republic of Turkey, and to investigate relationship of hand disorders and diabetes related laboratory and clinic data.
Materials and Methods: Patients with T2DM, 18-65 years old, who admitted to a tertiary hospital’s endocrinology outpatient clinic in Central Anatolian Region of Republic of Turkey were enrolled in the study, consecutively. Patients who had other diseases lead to hand disorders were excluded. Ptients’ demographic, diabetes related clinic and laboratory data were recorded. The information about the patients’ microvasculary and macrovasculary complications was obtained from hospital information system. Paitents’ hand examination was performed by a physiatrist who was blinded to patients’ DM related data.
Results: A total of 117 patients with T2DM, 86 of whom (73.5%) were women, were included in the study. Two third of the patients had hand complaints. Almost three fourth of the patients had at least one hand disorder. Prevalence of the hand complications was as follows; limited joint mobility: 43.6%; carpal tunnel syndrome: 54.7%; Dupuytren contracture: 13.7%; trigger finger: 7.7%; sclerodaktyly: 32.5%; and complex regional pain syndrome: 1.7%.
Conclusion: Hand involvement, which is one of the common complications in T2DM, was detected in almost 3 of every 4 patients in the follow-up patients of a tertiary hospital in Central Anatolia Region. When evaluating patients with T2DM, hand involvement should also be evaluated.

Project Number

-

References

  • American Diabetes Association. Standards of medical care in diabetes-2017. Diabetes Care. 2017;40:11–24.
  • Zyluk A, Puchalski P. Hand disorders associated with diabetes: a review. Acta Orthop Belg. 2015;81:191-196.
  • Savaş S, Köroğlu BK, Koyuncuoğlu HR, Uzar E, Celik H, Tamer NM. The effects of the diabetes related soft tissue hand lesions and the reduced hand strength on functional disability of hand in type 2 diabetic patients. Diabetes Res Clin Pract. 2007;77(1):77-83.
  • Hou WH, Li CY, Chen LH, et al. Medical claims-based case-control study of temporal relationship between clinical visits for hand syndromes and subsequent diabetes diagnosis: implications for identifying patients with undiagnosed type 2 diabetes mellitus. BMJ Open. 2016;6(10):e012071.
  • Dyck PJ, Albers JW, Andersen H, et al. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011; 27: 620–628.
  • Arkkila PET, Gautier JF. Musculoskeletal disorders in diabetes mellitus: an update. Best Pract Res Clin Rheumatol. 2003;17:945–970.
  • Kirazlı Y. Diyabetik El Rehabilitasyonu. FTR Bil Der. 2011:14 Özel Sayı;7-11.
  • Ardic F, Soyupek F, Kahraman Y, Yorgancıoğlu R. The musculoskeletal complications seen in type II diabetics: predominance of hand involvement. Clin Rheumatol. 2003;22: 229–233.
  • Cederlund RI, Thomsen N, Thrainsdottir S, Eriksson KF, Sundkvist G, Dahlin LB. Hand disorders, hand function, and activities of Daily living in elderly men with type 2 diabetes. J Diabetes Complications 2009;23:32-9.
  • Duyur Çakıt B, Özeri Z, Saraçoğlu M, Erdem HR. Diyabetes Mellituslu Hastalarda El ve Omuzu İlgilendiren Kas-İskelet Sistemi Komplikasyonları ve El Fonksiyonlarının Değerlendirilmesi. FTR Bil Der. 2009;12:99-103.
  • Ramchurn N, Mashamba C, Leitch E, et al. Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes. Eur J Intern Med 2009; 20:718.
  • Lebiedz-Odrbina D, Kay J. Rheumatic Manifestations of Diabetes Mellitus. Rheum Dis Clin N Am 2010;36:681–699.
  • Chammas M, Bousquet P, Renard E, Poirier JL, Jaffiol C & Allieu Y. Dupuytren's disease, carpal tunnel syndrome, trigger finger and diabetes mellitus. Journal of Hand Surgery, 20A:1995;109−114.
  • Comi G, Lozza L, Galardi G, et al. Prevalence of carpal tunnel syndrome in diabetics: Effects of age, sex diabetes duration and polyneuropathy. Acta Diabetologica Latina, 22:1985;259−262.
  • Becker J, Nora DB, Gomes I, et al. An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome. Clin Neurophysiol. 2002;113(9):1429–34.
  • Taşpınar Ş. Diyabetik Karpal Tünel Sendromunda Kortikosteroid Enjeksiyonu, Gece Ateli ve Fizik Tedavinin Etkinliğinin Karşılaştırılması (Uzmanlık Tezi). İstanbul:2005.
  • Comi G, Lozza L, Galardi G, et al. Prevalence of carpal tunnel syndrome in diabetics: Effects of age, sex diabetes duration and polyneuropathy. Acta Diabetologica Latina. 22:1985;259−262.
  • Gamstedt A, Holm-Glad J, Ohlson CG & Sundstrom M. Hand abnormalities are strongly associated with the duration of diabetes mellitus. Journal of Internal Medicine. 1993;234,189−193.
  • Alp R, Türk Börü Ü, Sargın H. : Tip 2 Diyabetlilerde Semptomatik Karpal Tünel Sendromu. Turkish J. Endocrinology and Metabolism. Vol. 7, No. 1, 2003.
  • Noble J, Heathcote JG & Cohen H. Diabetes mellitus in the aetiology of Dupuytren’s disease. Journal of Bone and Joint Surgery (Br) 1984; 66: 322–325.
  • Seibold JR. Digital sclerosis in children with insulin-dependent diabetes mellitus. Arthritis Rheum. 1982; 25:1357.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section Original Investigation
Authors

Kemal Erol 0000-0003-0673-3961

Hatice Uğurlu This is me 0000-0001-6728-232X

Project Number -
Publication Date August 18, 2020
Acceptance Date August 6, 2020
Published in Issue Year 2020 Volume: 3 Issue: 2

Cite

EndNote Erol K, Uğurlu H (August 1, 2020) Tip 2 Diyabetes Mellitus Tanılı Hastalarda El Komplikasyonları ve Klinik Verilerle İlişkisi. Ege Tıp Bilimleri Dergisi 3 2 67–73.

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