ejeas

European Journal of Engineering and Applied Sciences

2651-3412 2667-8454

Tekirdag Namik Kemal University

Engineering

Mühendislik

Preparation, Characterization and Drug Release Properties of Polyvinyl Alcohol and Polyvinyl Pyrolidone Blended Hydrogels

Polivinil Alkol Ve Polivinil Pirolidon Hidrojellerinin Sentezi, Karakterizasyonu Ve İlaç Salım Davranışları

Taşdelen

Betül

NAMIK KEMAL UNIVERSITY

12 18 2018

1 1 27 30 08 13 2018 12 14 2018

2018

European Journal of Engineering and Applied Sciences

In this work, a new polyvinyl alcohol (PVA)/polyvinyl pyrrolidone (PVP) /Pumice composite has been synthesized by using gamma rays irradiation technique. The chemical characteristics of the hydrogels were determined by Fourier Transform Infrared Spectroscopy method. The properties of the hydrogels were investigated in terms of swelling, drug uptake and release behaviors. 5-Fluorouracil (5-FU) was used as a model drug for the study of drug uptake and release behaviour of hydrogels. The addition of pumice in the gel structure improved drug uptake and release capability of the new hydrogels.

Bu çalışmada, yenibir polivinil alkol (PVA) / polivinil pirolidon (PVP)/Pomza kompozit malzemesigama ışınları ile radyasyon tekniği ile sentezlensi. Hidrojellerin kimyasalözellikleri Fourier Transform İnfrared Spektroskopi metotu ile belirlendi. Hidrojellerinşişme,, ilaç emilimi ve salım davranışları incelendi. 5-Fluorurasil (5-FU),hidrojellerin ilaç tutumu ve salım davranışlarının incelenmesinde model ilaçolarak kullanıldı. Pomzanın jel yapısına ilavesi hidrojellerin ilaç tutumu vesalım kapasitesini arttırdı.

Drug Hydrogel Polyvinyl alcohol Polyvinyl pyrrolidone Pumice

İlaç Hidrojel Polivinil alkol Polivinil prolidon Pomza

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