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Yedi aktif farmasötik bileşenin Aliivibrio fischeri toksisite testi ile su ortamına olan etkilerinin değerlendirilmesi

Year 2021, Volume 9, Issue 2, 47 - 53, 17.07.2021
https://doi.org/10.31195/ejejfs.842507

Abstract

Aktif farmasötik bileşenlerin çevresel kalıntıları, çevresel riskler ve sağlık sorunları ile ilişkilidir. Bunların çevreye olan etkileri toplumsal bir endişe konusu haline gelmiştir. Bu çalışmada; flurbiprofen, naproksen Na, propranolol HCl, karbamazepin, azitromisin, doksisiklin ve klindamisin ilaç etken maddelerinin toksisiteleri Aliivibrio fischeri toksisite testi kullanılarak belirlenmiştir. Aliivibrio fischeri toksisite testi deneyinde, ilaç etken maddelerinin 5. ve 15. dakika sonunda okunan değerlerine göre EC50 (mg/L) ve toksik birim (TB) hesaplanmıştır. 15. dk sonunda elde edilen EC50 değerlerine bakıldığında, EC50 değerleri en düşük çıkan ilaç aktif bileşenleri “doksisiklin, azitromisin ve klindamisin” dir. Bu antibiyotik grubu ilaç etken maddeleri “doksisiklin, azitromisin ve klindamisin” için EC50 değerleri sırasıyla; 0.10, 0.12 ve 0.76 mg/L olarak bulunmuştur. Farmasötiklerin Aliivibrio fischeri'ye akut toksisiteleri hakkında elde edilen veriler, ortaya çıkan kirleticilerle ilişkili çevresel risklerin değerlendirilmesini kolaylaştırabilir.

References

  • Azur. (1997). Microtox manual, Azur Environmental. (formely microbics corporation), 2232 Rutherford Road, Carlsbad, CA.
  • Conforti, F., Ioele,. G., Statti, G., A., Marrelly,. M., Ragno, G., Menichini, F. (2008). Antiproferative activity aganist human. tumor cell lines and toxicity test on mediterranean dietary plants. Food Chem. Toxicol. 46, 3325-3332.
  • Cotou, E., Papathanassiou,. E., Tsangaris,. C. (2002). Assessing the quality of marine coastal environments; Comparion of scope for growth and Microtox. bioassay results of pollution gradient areas in eastern. mediterranean (Greece), Environ. Pollut. 119, 141-149. Ellis, J. B. (2006). Pharmaceutical and personal care products (PPCPs). in urban receiving waters. Environ. Pollut. 144, 184-189.
  • Escher, B.I., Fenner, K. (2011). Recent advances. in environmental risk assessment of transformation. products. Environ. Toxicol.
  • Farré, M., Ferrer, I., Ginebreda, A., Figueras, M., Olivella, L., Tirapu, L., Vilanova, M., Barcelό, D. (2001). Determination of drugs in surface water and wastewater samples by liquid chromatography-mass. spectromtry: Methods. and preliminary results. including toxicity studies with Vibrio fischeri. Journal Of Chromatography. A. 958, 187-197.
  • Fisher, J. C., Belden, J. B., Bidwell, J. R. (2010). Can site-specific. heuristic models. predict the toxicity of produced water. Chemosphere. 80, 542-547.
  • Gellert, G. (2000). Sensitivity. and significance of luminescent bacteria in chronic toxicity testing based on growth and bioluminescence. Ecotox. Environ. Safe.
  • Gottlieb, D. (1976). The production and role of antibiotics in soil. J. Antibiot. 29, 987- 1000.
  • Gultekin, I., Ince, N. H. (2007). Synthetic endocrine disruptors in the environment and water remediation by advanced oxidation processes. J. Environ. Manage. 85, 816-832.
  • Hamscher, G., Priess, B., Nau, H. (2006). A survey. of the occurrence of various sulfonamides and tetracyclines in water and sediment samples. originating from aquaculture systems in Northern Germany in summer 2005. Arch. Lebensmittelhyg. 57, 97-101.
  • Kümmerer, K. (2011). Emerging contaminants. In: Frimmel, F. (Ed.), Treatise on Water Science, Elsevier, Oxford, Vol. 3 pp. 69–88.
  • Le-Minh, N., Stuetz, R.M., Khan, S.J. (2012). Determination of six sulfonamide antibiotics, two metabolites and trimethoprim in wastewater by isotope dilution liquid chromatography/tandem. mass spectrometry. Talanta, 89, 407-416.
  • Marugan, J., Bru, D., Pablos, C., Catala, M. (2012). Comparative evaluation of acute toxicity by Vibrio fischeri and fern spore based bioassay in the follow-up of toxic. chemicals degradation by photocatalysis. J. Hazard. Mater. 213-214, 117-122.
  • Nas, B., Dolu, T., Ateş, H., Argun, M. E., Yel, E. (2017), Treatment alternatives for micropollutant removal in wastewater. Selçuk Üniversitesi Mühendislik Fakültesi. 5 (2), 133-141.
  • Parvez, S., Venkataraman, C., Mukherji, S. (2006). A review on advantages of implementing luminescence. inhibition test (Vibrio fischeri) for acute toxicity. prediction of chemicals. Environ. Int.
  • Persoonee, G., Goyvaerts, M.P., Janssen, C.R., de Coen W. And Vangheluwe, M. (1993). Cost-effective acute hazard moniturin of polluted waters and waste drumps with the aid of Toxkits. Final Report, CEC Contract ACE 89/BE 2/D3, VABRAP, University of Ghent, Belgium, 600 pages.
  • Qin, M., Yang, H., Chen, S., Xie, H., Guan, J. (2012). Photochemical characteristics of diclofenac and its photodegradation of inclusion. complexes with β-cyclodextrins. Quim. Nova. 35, 559-562.
  • Rickman, K.A., Mezyk, S.P. (2010). Kinetics and mechanisms of sulfate radical oxidation of b-lactam antibiotics in water. Chemosphere, 81, 359-365.
  • Schnell, Bols, S. N. C., Barata, C., Porte, C. (2009). Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquat. Toxicol. 93, 244-252.
  • Schwarzenbach, R.P., Escher, B.I., Fenner, K., Hofstetter, T.B., Johnson, C.A., von Gunten, U., Wehrli, B. (2006). The challenge of micropollutants in aquatic systems. Science.
  • Tongur, S., Yıldız, S., Yıldırım, R. (2019). Bazı ilaç gruplarının su ortamına olan etkilerinin akut toksisite testleri ile değerlendirilmesi. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 23, 71-75. doi: 10. 19113/sdufenbed.435089.

Evaluation of the effects of seven active pharmaceutical ingredients on the aquatic environment with the Aliivibrio fischeri toxicity test

Year 2021, Volume 9, Issue 2, 47 - 53, 17.07.2021
https://doi.org/10.31195/ejejfs.842507

Abstract

Aktif farmasötik bileşenlerin çevresel kalıntıları, çevresel riskler ve sağlık sorunları ile ilişkilidir. Bunların çevreye olan etkileri toplumsal bir endişe konusu haline gelmiştir. Bu çalışmada; flurbiprofen, naproksen Na, propranolol HCl, karbamazepin, azitromisin, doksisiklin ve klindamisin ilaç etken maddelerinin toksisiteleri Vibrio fischeri toksisite testi kullanılarak belirlenmiştir. Vibrio fischeri toksisite testi deneyinde, ilaç etken maddelerinin 5. ve 15. dakika sonunda okunan değerlerine göre EC50 (mg/L) ve toksik birim (TB) hesaplanmıştır. 15. dk sonunda elde edilen EC50 değerlerine bakıldığında, EC50 değerleri en düşük çıkan ilaç aktif bileşenleri “doksisiklin, azitromisin ve klindamisin” dir. Bu antibiyotik grubu ilaç etken maddeleri “doksisiklin, azitromisin ve klindamisin” için EC50 değerleri sırasıyla; 0.10, 0.12 ve 0.76 mg/L olarak bulunmuştur. Farmasötiklerin Vibrio fischeri'ye akut toksisiteleri hakkında elde edilen veriler, ortaya çıkan kirleticilerle ilişkili çevresel risklerin değerlendirilmesini kolaylaştırabilir.

References

  • Azur. (1997). Microtox manual, Azur Environmental. (formely microbics corporation), 2232 Rutherford Road, Carlsbad, CA.
  • Conforti, F., Ioele,. G., Statti, G., A., Marrelly,. M., Ragno, G., Menichini, F. (2008). Antiproferative activity aganist human. tumor cell lines and toxicity test on mediterranean dietary plants. Food Chem. Toxicol. 46, 3325-3332.
  • Cotou, E., Papathanassiou,. E., Tsangaris,. C. (2002). Assessing the quality of marine coastal environments; Comparion of scope for growth and Microtox. bioassay results of pollution gradient areas in eastern. mediterranean (Greece), Environ. Pollut. 119, 141-149. Ellis, J. B. (2006). Pharmaceutical and personal care products (PPCPs). in urban receiving waters. Environ. Pollut. 144, 184-189.
  • Escher, B.I., Fenner, K. (2011). Recent advances. in environmental risk assessment of transformation. products. Environ. Toxicol.
  • Farré, M., Ferrer, I., Ginebreda, A., Figueras, M., Olivella, L., Tirapu, L., Vilanova, M., Barcelό, D. (2001). Determination of drugs in surface water and wastewater samples by liquid chromatography-mass. spectromtry: Methods. and preliminary results. including toxicity studies with Vibrio fischeri. Journal Of Chromatography. A. 958, 187-197.
  • Fisher, J. C., Belden, J. B., Bidwell, J. R. (2010). Can site-specific. heuristic models. predict the toxicity of produced water. Chemosphere. 80, 542-547.
  • Gellert, G. (2000). Sensitivity. and significance of luminescent bacteria in chronic toxicity testing based on growth and bioluminescence. Ecotox. Environ. Safe.
  • Gottlieb, D. (1976). The production and role of antibiotics in soil. J. Antibiot. 29, 987- 1000.
  • Gultekin, I., Ince, N. H. (2007). Synthetic endocrine disruptors in the environment and water remediation by advanced oxidation processes. J. Environ. Manage. 85, 816-832.
  • Hamscher, G., Priess, B., Nau, H. (2006). A survey. of the occurrence of various sulfonamides and tetracyclines in water and sediment samples. originating from aquaculture systems in Northern Germany in summer 2005. Arch. Lebensmittelhyg. 57, 97-101.
  • Kümmerer, K. (2011). Emerging contaminants. In: Frimmel, F. (Ed.), Treatise on Water Science, Elsevier, Oxford, Vol. 3 pp. 69–88.
  • Le-Minh, N., Stuetz, R.M., Khan, S.J. (2012). Determination of six sulfonamide antibiotics, two metabolites and trimethoprim in wastewater by isotope dilution liquid chromatography/tandem. mass spectrometry. Talanta, 89, 407-416.
  • Marugan, J., Bru, D., Pablos, C., Catala, M. (2012). Comparative evaluation of acute toxicity by Vibrio fischeri and fern spore based bioassay in the follow-up of toxic. chemicals degradation by photocatalysis. J. Hazard. Mater. 213-214, 117-122.
  • Nas, B., Dolu, T., Ateş, H., Argun, M. E., Yel, E. (2017), Treatment alternatives for micropollutant removal in wastewater. Selçuk Üniversitesi Mühendislik Fakültesi. 5 (2), 133-141.
  • Parvez, S., Venkataraman, C., Mukherji, S. (2006). A review on advantages of implementing luminescence. inhibition test (Vibrio fischeri) for acute toxicity. prediction of chemicals. Environ. Int.
  • Persoonee, G., Goyvaerts, M.P., Janssen, C.R., de Coen W. And Vangheluwe, M. (1993). Cost-effective acute hazard moniturin of polluted waters and waste drumps with the aid of Toxkits. Final Report, CEC Contract ACE 89/BE 2/D3, VABRAP, University of Ghent, Belgium, 600 pages.
  • Qin, M., Yang, H., Chen, S., Xie, H., Guan, J. (2012). Photochemical characteristics of diclofenac and its photodegradation of inclusion. complexes with β-cyclodextrins. Quim. Nova. 35, 559-562.
  • Rickman, K.A., Mezyk, S.P. (2010). Kinetics and mechanisms of sulfate radical oxidation of b-lactam antibiotics in water. Chemosphere, 81, 359-365.
  • Schnell, Bols, S. N. C., Barata, C., Porte, C. (2009). Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquat. Toxicol. 93, 244-252.
  • Schwarzenbach, R.P., Escher, B.I., Fenner, K., Hofstetter, T.B., Johnson, C.A., von Gunten, U., Wehrli, B. (2006). The challenge of micropollutants in aquatic systems. Science.
  • Tongur, S., Yıldız, S., Yıldırım, R. (2019). Bazı ilaç gruplarının su ortamına olan etkilerinin akut toksisite testleri ile değerlendirilmesi. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 23, 71-75. doi: 10. 19113/sdufenbed.435089.

Details

Primary Language Turkish
Subjects Forestry
Journal Section Articles
Authors

Süheyla TONGUR (Primary Author)
KONYA TEKNİK UNİVERSİTESIİ
0000-0002-8647-6338
Türkiye


Sevil YILDIZ This is me
KONYA TEKNİK UNİVERSİTESIİ
0000-0003-2873-9328
Türkiye

Publication Date July 17, 2021
Published in Issue Year 2021, Volume 9, Issue 2

Cite

APA Tongur, S. & Yıldız, S. (2021). Yedi aktif farmasötik bileşenin Aliivibrio fischeri toksisite testi ile su ortamına olan etkilerinin değerlendirilmesi . Eurasian Journal of Forest Science , 9 (2) , 47-53 . DOI: 10.31195/ejejfs.842507

hbarist@gmail.com

ISSN: 2147-7493