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SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY

Year 2006, Volume: 3 Issue: 3, 102 - 107, 01.09.2006

Mehmet Unlu Mehmet Melek Fatma Fidan Celal Kilit Levent Tetik Dayimi Kaya

Abstract

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Keywords

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References

  • Ferguson GT, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med 1993; 32: 1017–22
  • Siafakas NM, Vermeire P, Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J 1995;8: 1398–20
  • Belman MJ, Botnick WC, Shin JW. Inhaled broncho-dilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 153:967–75
  • Gross NJ. Ipratropium bromide. N Engl J Med 1998;319:486–94
  • Haddad E-B, Mak JCW, Barnes PJ. Characterization of [3H]Ba 679 BR, a antagonist, in human lung: radioligand binding and autoradiographic mapping. Mol Pharmacol 1994;45:899-907
  • Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 2002; 19: 217-24
  • Vincken W, van Noord JA, Greefhorst AP, et al. Dutch/Belgian Tiotropium Study Group: Improved health outcomes in patients with COPD during 1 yr’s treatment with tiotropium. Eur Respir J 2002;19:200-16
  • Malik M. Heart rate variability. Standarts of measurement, physiological interpretation, and clinical use. Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996;17:354-81
  • Casolo GC, Stroder P, Signorini C, et al. Heart rate variability during the acute phase of myocardial infarction. Circulation 1992;85:2073-79
  • Multicentre Post Infarction Research Group, Kleiger RE, Miller JP, Bigger JT, Moss AJ. Decreased heart rate variability and its association with increased mortality infarction. Am J Cardiol 1987;59:256–62 acute myocardial
  • Airaksinen KE, Ikaheimo MJ, Linnaluoto MK, Niemala M, Takkunen JT. Impaired vagal heart rate control in coronary artery disease. Br Heart J 1987;58:592-7
  • Nolan J, Batin PD, Andrews R, et al. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-HEART). Circulation 1998;98:1510–6
  • Pagani M, Malfatto G, Pierini S, et al. Spectral analysis of autonomic diabetic neuropathy. J Auton Nerv System 1988; 23:143-53
  • Ylitalo A, Airaksinen KE, Sellin L, Huikuri HV. Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension. Am J Cardiol 1999;83:885–9
  • Onrat E, Kaya D, Kerpeten K, et al. 2004. The effects of rilmenidine on cardiac autonomic function in healthy volunteers. Rev Esc Cardiol 2004;57:745-50
  • Cottin F., Papelier Y., Escourrou P. Effects of exercise load and breathing frequency on heart rate and and blood pressure variability during dynamic exercise. Int J Sports Med 1999;20:232-8
  • Hvizdos KM, Goa KL. Tiotropium bromide. Drugs 2002;62:1195-205
  • Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996;153:967–75
  • American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 1995;152:S77–S120
  • Gross NJ. Ipratropium bromide. N Engl J Med 1998;319:486–94
  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, and the GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163: 1256–76
  • Chapman KR, Smith DL, Rebuck AS, Leenen FHH. Hemodynamic effects of inhaled ipratropium bromide, alone and combined with an inhaled beta 2 -agonist. Am Rev Respir Dis 1985;132: 845–7
  • Sackner MA, Friedman M, Silva G, Fernandez R. Pulmonary hemodynamic effects of aerosols of isoproterenol and ipratropium in normal subjects and patients with reversible airways obstruction. Am Rev Respir Dis 1977;116: 1013–22
  • Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991;84:482–92
  • Watson JP, Nolan J, Elliot MW. Autonomic dysfunction in patients with nocturnal hypoventilation restrictive disease. Eur Respir J 1999;13: 1097–102 extrapulmonary
  • Suissa S, Blais L, Ernst P. Patterns of increasing beta agonist use and the risk of fatal or near-fatal asthma. Eur Respir J 1994;7:1602-9
  • Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near-death from asthma. N Engl J Med 1992;326:501-6
  • Lehrer PM, Hochron SM, Rausch L, Carr R. Effects of aerosol ipratropium bromide on cardiac vagal tone. Chest 1994;105: 1701-4
  • Kaya D, Barutcu I, Esen AM, Onrat E, Orman A, Unlu M. Comparison of the effects of ipratropium bromide and salbutamol on autonomic heart rate control. Europace 2004;6:602-7

SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY

Year 2006, Volume: 3 Issue: 3, 102 - 107, 01.09.2006

Mehmet Unlu Mehmet Melek Fatma Fidan Celal Kilit Levent Tetik Dayimi Kaya

Abstract

Aim: Anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled tiotropium on heart rate variability (HRV). Methods: A randomized, double-blind, crossover design study was conducted on 11 healthy volunteers. Tiotropium or placebo was administered in two different testing sessions. Time domain parameters; mean R-R interval (mean-RR), the standard deviation of R-R interval (SDNN) and the root mean square of successive R-R interval differences (RMSSD) and power spectral analysis of HRV were assessed in the supine position, during handgrip exercise and controlled breathing before and after drug administration. Results: There were no statistically significant difference in baseline HRV parameters obtained before each drug administration (p >0.05). HRV parameters obtained after each drug administration were found not to be different during supine position, controlled breathing and handgrip exercise. Conclusion: Administration of single dose tiotropium did not effect cardiac autonomic modulations in healthy volunteers. Key words: Tiotropium, heart rate variability, healthy volunteer

Keywords

Tiotropium heart rate variability healthy volunteer

References

  • Ferguson GT, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med 1993; 32: 1017–22
  • Siafakas NM, Vermeire P, Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J 1995;8: 1398–20
  • Belman MJ, Botnick WC, Shin JW. Inhaled broncho-dilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 153:967–75
  • Gross NJ. Ipratropium bromide. N Engl J Med 1998;319:486–94
  • Haddad E-B, Mak JCW, Barnes PJ. Characterization of [3H]Ba 679 BR, a antagonist, in human lung: radioligand binding and autoradiographic mapping. Mol Pharmacol 1994;45:899-907
  • Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 2002; 19: 217-24
  • Vincken W, van Noord JA, Greefhorst AP, et al. Dutch/Belgian Tiotropium Study Group: Improved health outcomes in patients with COPD during 1 yr’s treatment with tiotropium. Eur Respir J 2002;19:200-16
  • Malik M. Heart rate variability. Standarts of measurement, physiological interpretation, and clinical use. Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996;17:354-81
  • Casolo GC, Stroder P, Signorini C, et al. Heart rate variability during the acute phase of myocardial infarction. Circulation 1992;85:2073-79
  • Multicentre Post Infarction Research Group, Kleiger RE, Miller JP, Bigger JT, Moss AJ. Decreased heart rate variability and its association with increased mortality infarction. Am J Cardiol 1987;59:256–62 acute myocardial
  • Airaksinen KE, Ikaheimo MJ, Linnaluoto MK, Niemala M, Takkunen JT. Impaired vagal heart rate control in coronary artery disease. Br Heart J 1987;58:592-7
  • Nolan J, Batin PD, Andrews R, et al. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-HEART). Circulation 1998;98:1510–6
  • Pagani M, Malfatto G, Pierini S, et al. Spectral analysis of autonomic diabetic neuropathy. J Auton Nerv System 1988; 23:143-53
  • Ylitalo A, Airaksinen KE, Sellin L, Huikuri HV. Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension. Am J Cardiol 1999;83:885–9
  • Onrat E, Kaya D, Kerpeten K, et al. 2004. The effects of rilmenidine on cardiac autonomic function in healthy volunteers. Rev Esc Cardiol 2004;57:745-50
  • Cottin F., Papelier Y., Escourrou P. Effects of exercise load and breathing frequency on heart rate and and blood pressure variability during dynamic exercise. Int J Sports Med 1999;20:232-8
  • Hvizdos KM, Goa KL. Tiotropium bromide. Drugs 2002;62:1195-205
  • Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996;153:967–75
  • American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 1995;152:S77–S120
  • Gross NJ. Ipratropium bromide. N Engl J Med 1998;319:486–94
  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, and the GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163: 1256–76
  • Chapman KR, Smith DL, Rebuck AS, Leenen FHH. Hemodynamic effects of inhaled ipratropium bromide, alone and combined with an inhaled beta 2 -agonist. Am Rev Respir Dis 1985;132: 845–7
  • Sackner MA, Friedman M, Silva G, Fernandez R. Pulmonary hemodynamic effects of aerosols of isoproterenol and ipratropium in normal subjects and patients with reversible airways obstruction. Am Rev Respir Dis 1977;116: 1013–22
  • Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991;84:482–92
  • Watson JP, Nolan J, Elliot MW. Autonomic dysfunction in patients with nocturnal hypoventilation restrictive disease. Eur Respir J 1999;13: 1097–102 extrapulmonary
  • Suissa S, Blais L, Ernst P. Patterns of increasing beta agonist use and the risk of fatal or near-fatal asthma. Eur Respir J 1994;7:1602-9
  • Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near-death from asthma. N Engl J Med 1992;326:501-6
  • Lehrer PM, Hochron SM, Rausch L, Carr R. Effects of aerosol ipratropium bromide on cardiac vagal tone. Chest 1994;105: 1701-4
  • Kaya D, Barutcu I, Esen AM, Onrat E, Orman A, Unlu M. Comparison of the effects of ipratropium bromide and salbutamol on autonomic heart rate control. Europace 2004;6:602-7
There are 29 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Mehmet Unlu This is me

Mehmet Melek This is me

Fatma Fidan This is me

Celal Kilit This is me

Levent Tetik This is me

Dayimi Kaya This is me

Publication Date September 1, 2006
Published in Issue Year 2006 Volume: 3 Issue: 3

Cite

APA Unlu, M., Melek, M., Fidan, F., Kilit, C., et al. (2006). SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY. European Journal of General Medicine, 3(3), 102-107.
AMA Unlu M, Melek M, Fidan F, Kilit C, Tetik L, Kaya D. SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY. European Journal of General Medicine. September 2006;3(3):102-107.
Chicago Unlu, Mehmet, Mehmet Melek, Fatma Fidan, Celal Kilit, Levent Tetik, and Dayimi Kaya. “SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY”. European Journal of General Medicine 3, no. 3 (September 2006): 102-7.
EndNote Unlu M, Melek M, Fidan F, Kilit C, Tetik L, Kaya D (September 1, 2006) SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY. European Journal of General Medicine 3 3 102–107.
IEEE M. Unlu, M. Melek, F. Fidan, C. Kilit, L. Tetik, and D. Kaya, “SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY”, European Journal of General Medicine, vol. 3, no. 3, pp. 102–107, 2006.
ISNAD Unlu, Mehmet et al. “SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY”. European Journal of General Medicine 3/3 (September 2006), 102-107.
JAMA Unlu M, Melek M, Fidan F, Kilit C, Tetik L, Kaya D. SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY. European Journal of General Medicine. 2006;3:102–107.
MLA Unlu, Mehmet et al. “SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY”. European Journal of General Medicine, vol. 3, no. 3, 2006, pp. 102-7.
Vancouver Unlu M, Melek M, Fidan F, Kilit C, Tetik L, Kaya D. SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY. European Journal of General Medicine. 2006;3(3):102-7.