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Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats

Year 2003, Volume: 8 Issue: 2, 35 - 40, 26.02.2013

Abstract

Objective: We aimed to investigate median lethal dose
(LD50) and hypoglycemic effect of fixed oil of
Foeniculum vulgare Miller seed fixed oil (FFO) in mice
and its hepatoprotective effect on carbon tetrachloride
(CCl4) induced liver injury model in rats.
Method: Extract of FFO, glibenclamide (as a reference
group) and physiologic saline (control group) were
administrated to the healthy and diabet occured mice
with alloxan. Before treatment in the first, second, third,
fourth and 24th hours, blood was taken from the vena
coccygea of mice. Blood glucose levels were
measured.
Twenty-four Sprague-Dawley rats were divided into
four groups (n=6), and the groups treated daily for
seven days, by i.p. injections, of isotonic saline solution
(ISS), olive oil, carbon tetrachloride (CCl4), CCl4 + FFO
respectively.
Results:  FFO did not significantly reduced blood
glucose in alloxane-induced diabetic mice compared
to ISS control group. In contrast, glibenclamide
effectively reduced blood glucose of alloxane-induced
mice in first, second, fourth and 24th hours as expected.
In the CCl4-treated group and FFO-treated group serum
aspartate aminotransferase (AST), alanine
aminotransferase (ALT) and alkaline phosphatase
(ALP) levels were quite high. In contrast, the control
groups (group I and group II) had significantly lower
levels of AST and ALT when compared with the CCl4
and FFO groups.
Conclusion: The results of this study indicate that FFO
has neither a potent hepatoprotective effect against
CCl4-induced hepatic damage in rats nor a
hypoglycemic action in mice. The LD50 of FFO was
determined as 5.52 mL/kg.
Key words: Foeniculum vulgare Miller, fennel fixed oil,
median lethal dose, hepatoprotective effect, hypoglycemic
effect.

Year 2003, Volume: 8 Issue: 2, 35 - 40, 26.02.2013

Abstract

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Details

Primary Language English
Journal Section Articles
Authors

HANEFİ Özbek This is me

Mustafa Öztürk This is me

İrfan Bayram This is me

Serdar Uğraş This is me

GÜLÇİN Saltan Çitoğlu This is me

Publication Date February 26, 2013
Published in Issue Year 2003 Volume: 8 Issue: 2

Cite

APA Özbek, H., Öztürk, M., Bayram, İ., Uğraş, S., et al. (2013). Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. EASTERN JOURNAL OF MEDICINE, 8(2), 35-40.
AMA Özbek H, Öztürk M, Bayram İ, Uğraş S, Saltan Çitoğlu G. Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. EASTERN JOURNAL OF MEDICINE. March 2013;8(2):35-40.
Chicago Özbek, HANEFİ, Mustafa Öztürk, İrfan Bayram, Serdar Uğraş, and GÜLÇİN Saltan Çitoğlu. “Hypoglycemic and Hepatoprotective Effects of Foeniculum Vulgare Miller Seed Fixed Oil Extract InMice and Rats”. EASTERN JOURNAL OF MEDICINE 8, no. 2 (March 2013): 35-40.
EndNote Özbek H, Öztürk M, Bayram İ, Uğraş S, Saltan Çitoğlu G (March 1, 2013) Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. EASTERN JOURNAL OF MEDICINE 8 2 35–40.
IEEE H. Özbek, M. Öztürk, İ. Bayram, S. Uğraş, and G. Saltan Çitoğlu, “Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats”, EASTERN JOURNAL OF MEDICINE, vol. 8, no. 2, pp. 35–40, 2013.
ISNAD Özbek, HANEFİ et al. “Hypoglycemic and Hepatoprotective Effects of Foeniculum Vulgare Miller Seed Fixed Oil Extract InMice and Rats”. EASTERN JOURNAL OF MEDICINE 8/2 (March 2013), 35-40.
JAMA Özbek H, Öztürk M, Bayram İ, Uğraş S, Saltan Çitoğlu G. Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. EASTERN JOURNAL OF MEDICINE. 2013;8:35–40.
MLA Özbek, HANEFİ et al. “Hypoglycemic and Hepatoprotective Effects of Foeniculum Vulgare Miller Seed Fixed Oil Extract InMice and Rats”. EASTERN JOURNAL OF MEDICINE, vol. 8, no. 2, 2013, pp. 35-40.
Vancouver Özbek H, Öztürk M, Bayram İ, Uğraş S, Saltan Çitoğlu G. Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. EASTERN JOURNAL OF MEDICINE. 2013;8(2):35-40.