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Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene

Year 2000, Volume: 5 Issue: 2, 70 - 78, 19.03.2003

Abstract

Objective: We have confirmed by PCR-amplification of
the DNA polymerase gene, three cases of Herpes Sim-plex encephalitis (HSE) with atypical clinical symp-toms.
Methods: Cerebrospinal fluid (CSF) samples were col-lected by lumbar puncture during the course of test-ing from 23 patients suspected to have viral encepha-litis based on commonly encountered symptoms, cy-tochemical analysis and neurological testing. PCR was
done on CSF using specific primers that amplify a 290
base pair sequence on the DNA polymerase gene com-mon to both HSV-1 and HSV-2 strains.
Results:  Only 3 of the 23 CSF samples collected
showed the expected amplicon size on the target se-quence. One case had conventional symptoms of en-cephalitis and 2 cases showed atypical symptoms from
the conventional ones. All 3 patients recovered after
administration of acyclovir. Fourteen PCR-negative
patients were shown to have non-HSE viral encephali-tis and the remaining 6 patients were shown later to
have other neurological diseases.
Conclusion:   PCR was efficient in elucidating the atypi-cal cases of HSV encephalitis.
Key words: HSV, encephalitis, PCR

Year 2000, Volume: 5 Issue: 2, 70 - 78, 19.03.2003

Abstract

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Details

Primary Language English
Journal Section Articles
Authors

G.m. Mantar This is me

W.a. Khoudoud This is me

M. Fayad This is me

R. Choueiri This is me

M. Mikati This is me

A.m. Abdelnoor This is me

Publication Date March 19, 2003
Published in Issue Year 2000 Volume: 5 Issue: 2

Cite

APA Mantar, G., Khoudoud, W., Fayad, M., Choueiri, R., et al. (2003). Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene. EASTERN JOURNAL OF MEDICINE, 5(2), 70-78.
AMA Mantar G, Khoudoud W, Fayad M, Choueiri R, Mikati M, Abdelnoor A. Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene. EASTERN JOURNAL OF MEDICINE. March 2003;5(2):70-78.
Chicago Mantar, G.m., W.a. Khoudoud, M. Fayad, R. Choueiri, M. Mikati, and A.m. Abdelnoor. “Herpes Simplex Encephalitis Cases With Typical and Atypical Symptoms Confirmed by PCR-Am- Plification of the DNA Polymerase Gene”. EASTERN JOURNAL OF MEDICINE 5, no. 2 (March 2003): 70-78.
EndNote Mantar G, Khoudoud W, Fayad M, Choueiri R, Mikati M, Abdelnoor A (March 1, 2003) Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene. EASTERN JOURNAL OF MEDICINE 5 2 70–78.
IEEE G. Mantar, W. Khoudoud, M. Fayad, R. Choueiri, M. Mikati, and A. Abdelnoor, “Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene”, EASTERN JOURNAL OF MEDICINE, vol. 5, no. 2, pp. 70–78, 2003.
ISNAD Mantar, G.m. et al. “Herpes Simplex Encephalitis Cases With Typical and Atypical Symptoms Confirmed by PCR-Am- Plification of the DNA Polymerase Gene”. EASTERN JOURNAL OF MEDICINE 5/2 (March 2003), 70-78.
JAMA Mantar G, Khoudoud W, Fayad M, Choueiri R, Mikati M, Abdelnoor A. Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene. EASTERN JOURNAL OF MEDICINE. 2003;5:70–78.
MLA Mantar, G.m. et al. “Herpes Simplex Encephalitis Cases With Typical and Atypical Symptoms Confirmed by PCR-Am- Plification of the DNA Polymerase Gene”. EASTERN JOURNAL OF MEDICINE, vol. 5, no. 2, 2003, pp. 70-78.
Vancouver Mantar G, Khoudoud W, Fayad M, Choueiri R, Mikati M, Abdelnoor A. Herpes Simplex Encephalitis Cases with Typical and Atypical Symptoms Confirmed by PCR-Am- plification of the DNA Polymerase Gene. EASTERN JOURNAL OF MEDICINE. 2003;5(2):70-8.