Anti-inflammatory effects of Sanguisorba minor Scop. subsp. muricata (Spach) Briq. and Cirsium libanoticum DC. subsp. lycaonicum (Boiss. & Heldr.) Davis & Parris in rat

Year 2015, Volume: 20 Issue: 2, 81 - 85, 10.07.2015

Okan Arıhan , Hanefi Özbek Ayşe Gençler Özkan

Abstract

An ethnobotanical research conducted in Pınarbaşı, Kayseri, revealed that Sanguisorba minor Scop. subsp. muricata (Spach) Briq. (Smm) is commonly used for wounds and burns and Cirsium libanoticum DC. subsp. lycaonicum (Boiss. & Heldr.) Davis & Parris (Cll) is used especially to treat pressure wounds suffered by bedridden patients. This study was performed to assess any possible anti-inflammatory effect of these two folk medicinal plants.

Aqueous extracts of Smm and Cll were prepared at room temperature with maceration. Extracts were given at doses of 25, 50 and 100 mg/kg to rats. Anti-inflammatory test was performed to animals after 30 minutes of intraperitoneal injection. Smm and Cll extracts exerted anti-inflammatory activity in a dose dependent fashion.

Control group shows 1.1 % (mL) paw edema following lambda-carrageenan injection. Aqueous extracts of Smm showed 41.9, 76.4 and 83.4 % anti-inflammatory activity at 25, 50 and 100 mg/kg doses respectively. Similarly aqueous extracts of Cll showed 20.9, 34.2 and 53.5 % anti-inflammatory activity at 25, 50 and 100 mg/kg doses respectively.

In addition, Smm was more potent anti-inflammatory plant than Cll. These findings suggest that traditional use of these subspecies of Smm and Cll for anti-inflammatory activity have an ethnopharmacological relevance.

Keywords

Sanguisorba, Cirsium, anti-inflammatory, paw edema, carrageenan

References

• Tuzlacı E, Erol MK. Turkish folk medicinal plants. Part II: Egirdir Isparta, Fitoter 1999; 70:593-610.
• Baytop T. Therapy with medicinal plants in Turkey (Past and present), Istanbul University. Publications, No. 3255/40, Istanbul (in Turkish), 1984.
• Gürbüz I, Özkan AM, Yesilada E, Kutsal O. Anti- ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri-Turkey). J Ethnopharm 2005; 101:313-318.
• Gençler Özkan AM, Koyuncu M. Traditional medicinal plants used in Pınarbaşı Area (Kayseri- Turkey). Turk J Pharm Sci 2005; 2:63-82.
• Davis PH. Flora of Turkey and the East Aegean Islands, Vol. 5. Edinburgh University Press, Edinburgh, 1979b.
• Davis PH, Mill RR, Tan K, (eds.). Flora of Turkey and the East Aegean Islands (Suppl. 1), Vol. 10. Edinburgh, Edinburgh University Press, 1988.
• Güner A, Özhatay N, Ekim T, Başer KHC, (eds.). Flora of Turkey and the East Aegean Islands (Suppl. 2), Vol. 11, 92-94. Edinburgh, Edinburgh University Press, 2000.
• Fernández-Martínez E, Díaz-Espinoza R, Villavicencio-Nieto MA, et al. Preliminary phytochemical and biological study of Cirsium ehrenbergii. Proc West Pharm Soc 2007; 50:162-164.
• Kim EY, Jho HK, Kim DI, Rhyu MR. Cirsium japonicum elicits endothelium-dependent relaxation via histamine H(1)-receptor in rat thoracic aorta. J Ethnopharm 2008; 116:223-227.
• Kim DY, Kang SH, Ghil SH. Cirsium japonicum extract induces apoptosis and anti-proliferation in the human breast cancer cell line MCF-7. Mol Med Rep 2010; 3:427-432.
• Walesiuk A, Nazaruk J, Braszko JJ. Pro-cognitive effects of Cirsium rivulare extracts in rats. J Ethnopharmacol 2010; 129:261-266.
• Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K, Miri R. Immunomodulatory activities of various medicinal plant extracts: effects on human lymphocytes apoptosis. Imm Invest 2009; 38:181-192.
• Liao Z, Chen X, Wu M. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. Arch Pharm Res 2010; 33:353-362.
• Nazaruk J, Czechowska SK, Markiewicz R, Borawska MH. Polyphenolic compounds and in vitro antimicrobial and antioxidant activity of aqueous extracts from leaves of some Cirsium species. Nat Prod Res 2008; 22:1583-1588.
• Barbour EK, Al Sharif M, Sagherian VK, et al. Screening of selected indigenous plants of Lebanon for antimicrobial activity. J Ethnopharm 2004; 93:1-7.
• Ku KL, Tsai CT, Chang WM, Shen ML, Wu CT, Liao HF. Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. Am J Chin Med 2008; 36:355-368.
• Lim H, Son KH, Chang HW, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull 2008; 31:2063-2067.
• Benedec D, Pârvu AE, Oniga I, et al. Anti- inflammatory activity of some plant extracts. In: Proceedings of the Fifth Conference on Medicinal and Aromatic Plants of Southeast European Countries, (5th CMAPSEEC), Brno, Czech Republic, 2-5 September, 46, 2008.
• Di Lorenzo C, Dell'Agli Badea M, Dima L, et al. Plant Food Supplements with Anti-Inflammatory Properties: A Systematic Review (II). Crit Rev Food Sci Nut 2013; 53:507-516.
• Talhouk RS, Karam C, Fostok S, El-Jouni W, Barbour EK. Anti-Inflammatory Bioactivities in Plant Extracts. J Med Food 2007; 10:1-10.
• Winter CA, Risley EA, Nuss GW. Carrageenin- induced edema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962; 111:544-547.
• Rimbau V, Cerdan C, Vila R. Anti-inflammatory activity of some extracts from plants used in the traditional medicine of North-African countries (II). Phytother Res 1999; 13:128-132.
• Kouadio F, Kanko C, Juge M, et al. Analgesic and anti-inflammatory activities of an extract from Parkia biglobosa used in traditional medicine in the Ivory Coast. Phytother Res 2000; 14:635-637.
• Martínez-Vázquez M, Apan TOR, Lastra AL, Bye R. A Comparative Study of the Analgesic and Anti- Inflammatory Activities of Pectolinarin Isolated from Cirsium subcoriaceumand Linarin Isolated from Buddleia cordata. Plant Med 1998; 64:134-137.
• Jung HA, Jin SE, Min B, Kim B, Choi JS. Anti- inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O- glucoside. Food Chem Toxicol 2012; 50:2171-2179.
• Lee S, Jung MJ, Heo S, Wang M. Anti-inflammatory effect and hplc analysis of extract from edible Cirsium setidens. J Kor Soc Appl Biol Chem 2009; 52:437- 442.
• Ravipati AS, Zhang L, Koyyalamudi SR, et al. Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complement Altern Med 2012; 12:173.