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            <front>

                <journal-meta>
                                                                <journal-id>eur j rhinol allergy</journal-id>
            <journal-title-group>
                                                                                    <journal-title>European Journal of Rhinology and Allergy</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2636-8072</issn>
                                                                                            <publisher>
                    <publisher-name>Turkish Rhinology Society</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Otorhinolaryngology</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Kulak Burun Boğaz</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Pediatric Rhinosinusitis: Its Predisposing Factors and Management</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-2156-9840</contrib-id>
                                                                <name>
                                    <surname>Subha</surname>
                                    <given-names>Sethu Thakachy</given-names>
                                </name>
                                                                    <aff>Department of Otorhinolaryngology, Universiti Putra Malaysia Faculty of Medicine &amp; Health Sciences (UPM)</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20240820">
                    <day>08</day>
                    <month>20</month>
                    <year>2024</year>
                </pub-date>
                                        <volume>7</volume>
                                        <issue>2</issue>
                                        <fpage>67</fpage>
                                        <lpage>71</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20240624">
                        <day>06</day>
                        <month>24</month>
                        <year>2024</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20240802">
                        <day>08</day>
                        <month>02</month>
                        <year>2024</year>
                    </date>
                            </history>
                        
                                                                                                <abstract><p>Objective: Rhinosinusitis is a prevalent disease in children that can cause many substantial physical symptoms and have a detrimental influence on their quality of life. This study aims to evaluate the predisposing factors, and management of pediatric rhinosinusitis patients.Methods: A cross-sectional study using retrospective data from 324 pediatric rhinosinusitis patients was conducted. Demographics, predisposing factors, and management were recorded.Results: Many of the affected patients (50.3%) were between 6 and 11 years old. The predisposing factors were allergic rhinitis (97.2%), asthma (27.2%), upper respiratory tract infection (24.4%), adenoid hypertrophy (17.9%), and gastro-oesophageal reflux disease (0.6%). A significant association was found between the age group with upper respiratory infection as a predisposing factor in pediatric rhinosinusitis (P-value .000). Most of our patients (99.7%) responded well to medical treatment, and 8.6% of them underwent surgical therapy, mainly adenotonsillectomy.Conclusion: This study demonstrated that allergic rhinitis was the most established predisposing factor for pediatric rhinosinusitis, followed by asthma, upper respiratory tract infection, and adenoid hypertrophy. Medical therapy was the mainstay of treatment for pediatric rhinosinusitis patients.</p></abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Allergic rhinitis</kwd>
                                                    <kwd>  pediatric</kwd>
                                                    <kwd>  predisposing factors</kwd>
                                                    <kwd>  rhinosinusitis</kwd>
                                                    <kwd>  upper respiratory tract infection</kwd>
                                            </kwd-group>
                            
                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Leo G, Incorvaia C, Cazzavillan A, Consonni D. May chronic rhinosinusitis in children be diagnosed by clinical symptoms? Int J Pediatr Otorhinolaryngol. 2015;79(6):825-828.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Ramadan HH. Chronic rhinosinusitis in children. Int J Pediatr. 2012;2012:573942.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Fokkens WJ, Lund VJ, Hopkins C, et al. Executive summary of EPOS 2020 including integrated care pathways. Rhinology. 2020;58(2):82-111.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Quintanilla-Dieck L, Lam DJ. Chronic rhinosinusitis in children. Curr Treat Options Pediatr. 2018;4(4):413-424.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Ramadan HH, Chaiban R, Makary C. Pediatric rhinosinusitis. Pediatr Clin North Am. 2022;69(2):275-286.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Badr DT, Gaffin JM, Phipatanakul W. Pediatric rhinosinusitis. Curr Treat Options Allergy. 2016;3(3):268-281.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Otto WR, Paden WZ, Connors M, et al. Suppurative intracranial complications of pediatric sinusitis: a single-center experience. J Pediatr Infect Dis Soc. 2021;10(3):309-316.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Shahid SK. Rhinosinusitis in children. ISRN Otolaryngol. 2012;2012:851831.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Siddiqui Z, Tahiri M, Gupta A, Kin Nam RH, Rachmanidou A. The management of paediatric rhinosinusitis. Int J Pediatr Orl. 2021;147:110786.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Kim NN, Marikar D. Antibiotic prescribing for upper respiratory tract infections: NICE guidelines. Arch Dis Child Educ Pract Ed. 2020;105(2):104-106.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(Suppl S29):1-464.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Orb Q, Curtin K, Oakley GM, et al. Familial risk of pediatric chronic rhinosinusitis. Laryngoscope. 2016;126(3):739-745.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Sedaghat AR, Phipatanakul W, Cunningham MJ. Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis. Int J Pediatr Orl. 2014;78(2):343-347.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Marom T, Alvarez-Fernandez PE, Jennings K, Patel JA, McCormick DP, Chonmaitree T. Acute bacterial sinusitis complicating viral upper respiratory tract infection in young children. Pediatr Infect Dis J. 2014 ;33(8):803-808.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">DeMuri GP, Eickhoff JC, Gern JC, Wald ER. Clinical and virological characteristics of acute sinusitis in children. Clin Infect Dis. 2019;69(10):1764-1770.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Poddighe D, Brambilla I, Licari A, Marseglia GL. Pediatric rhinosinusitis and asthma. Respir Med. 2018;141:94-99.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Vujnovic SD, Domuz A. Epidemiological aspects of rhinitis and asthma: comorbidity or united airway disease [Internet]. Asthma Diagnosis and Management - Approach Based on Phenotype and Endotype. InTech. 2018.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Chang CC. Sinusitis, rhinitis, asthma, and the single airway hypothesis. Dis Sinuses. 2013;5:173-194.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Fuller CG, Schoettler JJ, Gilsanz V, Nelson MD, Church JA, Richards W. Sinusitis in status asthmaticus. Clin Pediatr. 1994;33(12):712-719.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy. 2016;9:93-100.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Ramaswamy US, Patel VA, Lee SE. Managing chronic rhinosinusitis in severe asthma. Curr Opin Pulm Med. 2021;27(1):23-28.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Belcher R, Virgin F. The role of the adenoids in pediatric chronic rhinosinusitis. Med Sci (Basel). 2019;7(2):35.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Shin KS, Cho SH, Kim KR, et al. The role of adenoids in pediatric rhinosinusitis. Int J Pediatr Orl. 2008;72(11):1643-1650.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Nation J, Kaufman M, Allen M, Sheyn A, Coticchia J. Incidence of gastroesophageal reflux disease and positive maxillary antral cultures in children with symptoms of chronic rhinosinusitis. Int J Pediatr Orl. 2014;78(2):218-222.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Beatrice M, John A, Ahmed L, Peter M. Prevalence of chronic rhinosinusitis in children with dyspepsia–A cross sectional study. Egypt J Ear Nose Throat Allied Sci. 2016;17(3):139-142.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Goh YY, Keshavarzi F, Chew YL. Prevalence of atopic dermatitis and pattern of drug therapy in Malaysian children. Dermatitis. 2018;29(3):151-161.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Simpson EL. Comorbidity in atopic dermatitis. Curr Dermatol Rep. 2012;1(1):29-38.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Paller AS, Mina-Osorio P, Vekeman F, et al. Prevalence of type 2 inflammatory diseases in pediatric patients with atopic dermatitis: Real-world evidence. J Am Acad Dermatol. 2022;86(4):758-765.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;3(3):CD006394.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">Vasco CTC, Morais HC, Avelino MAG. Systematic review of the literature on surgical treatment of chronic rhinosinusitis in children: what is the best approach? Rev Paul Pediatr. 2020;38:e2018068.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
