Colchicine Intoxication In A Patient With Unilateral Renal Agenesis

Year 2021, Volume: 3 Issue: 2, 36 - 38, 15.12.2021

Mehmet Ali Yağlı , Damlanur Üstün

https://doi.org/10.51262/ejtox.769021

Abstract

Colchicine is an alkaloid used in the treatment of acute gout attacks, Familial Mediterranean Fever, Behçet's Disease and inflammatory bowel diseases. Depending on the dose taken, the clinic occurs in various ways. Gastrointestinal manifestations are common in colchicine intoxication, but multi-organ failure is a more rare and more serious problem. As the blood level of colchicine is determined by the kidney and the liver, toxicity may progress more rapidly in dysfunction of these organs. In this case report, we aimed to remind that colchicine intoxications may be more mortal in patients with renal insufficiency.

Keywords

Renal failure, Renal agenesis, colchicine intoxication

References

• Referans1-Gilman AG, Goodman LS, Rall TW, et al. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 8th ed. New York, Macmillan 1990;674-6.
• Referans2- Amanova A, Kendi Celebi Z, Bakar F, Caglayan MG, Keven K. Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. Clin Transplant. 2014 Aug 14. doi: 10.1111/ctr.12448. [Epub ahead of print]
• Referans3- Kaplan MM, DeLellis RA, Wolfe HJ. Sustained biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment. Ann Intern Med. 1997;126:682–688
• Referans4-Bismuth C, Baud F, Dally S. Standardized prognosis evaluation in acute toxicology: Its benefit in colchicine, paraquat and digitalis poisonings. J Toxicol Clin Exp 1986; 6:33-38.
• Referans5- Weakley-Jones B, Gerber JE, Biggs G. Colchicine poisoning: Case report of two homicides. Am J Forensic Med Pathol 2001;22:203-206.
• Referans6- Jarvie D, Park J, Stewart MJ. Estimation of colchicine in a poisoned patient by using high performance liquid chromatography. Clin Toxicol 1979; 14: 375-381.
• Referans7- Jayaprakash V, Ansell G, Galler D. Colchicine overdose: the devil is in the detail. N Z M J. 2007;120:1248.
• Referans8- Biçer S, Soysal DD, Çıtak A, Uçsel R, Karaböcüoğlu M, Uzel N. Acute colchicine intoxication in a child: a case report. Pediatr Emer Care. 2007;23: 314–317.
• Referans9- Milne ST, Meek PD. Fatal colchicine overdose: report of a case and review of the literature. Am J Emerg Med 1998; 16:603-608.
• Referans10- Stapczynski JS, Rothstein RJ, Gaye WA, Niemann JT. Colchicine overdose: report of two cases and review of the literature. Ann Emerg Med 1981; 10: 364-369.