Nabumeton İçeren Tabletlerde Yeni Miktar Tayin Yöntemleri ve Diğer Yöntemlerle Karşılaştırması

Year 2020, , 61 - 87, 20.03.2020

Yalçın Eroğlu

https://doi.org/10.18185/erzifbed.678258

Abstract

Türkiye'de Relifex film tablet adı altında satılan ve non-steroidal antienflamatuvar
etkili, romatoid artrit ve osteoartrit tedavisinde endike bir bileşik olan
nabumetonun preparatlardaki miktarlarının tayini için yeni yöntemler
geliştirilmiştir. Çalışmada, HPLC, HPTLC, ¹H-NMR ve LC/MS yöntemleri
olmak üzere dört yeni yöntem geliştirilmiş ve bulunan yöntemler ticari
tabletlere uygulanmıştır. Dört ayrı yöntemin sonuçları istatistiksel olarak
değerlendirilmiş ve kendi aralarında hassasiyet, çabukluk, kolay
uygulanabilirlik ve ekonomik yönden karşılaştırılması yapılmıştır. Geliştirilen
bu yeni yöntemler günümüzde rutin analizlerde uygulanan UV yönteminden daha
hassas ve daha iyidir. Bu çalışmayla, ilaç sanayinde ve ilaçların piyasa ile
ruhsat aşamasındaki kontrollerinde teknolojinin yakından takip edilmesi
gerekliliği açıkça ortaya konulmaktadır. Kantitatif ilaç analizlerinde daha
kesin sonuç veren, kolaylıkla uygulanabilen ve insan hatasının en aza
indirgendiği yeni cihazları kullanmak ve birlikte getirdikleri modern
teknolojilerle analizleri gerçekleştirmek kaçınılmazdır.

Keywords

Nabumeton, LC/MS, HPTLC, 1H-NMR

Thanks

Bu çalışmada, tez konumu belirleyen, çalışmalarımı yöneten, çalışmalarımın her aşamasında değerli katkılarını gördüğüm rahmetli hocam Prof. Dr. Tuncel ÖZDEN’e teşekkür ve şükranlarımı sunar, cenab-ı haktan rahmet dilerim. Mekanın cennet olsun hocam…

New Determination of Nabumetone-containing Tablets and Their Comparison with Other Methods

Abstract

New methods have been developed to determine the
amount of nabumetone in preparations sold under the commercial name
"Relifex” in Turkey, to treat the symptoms related to the rheumatoid
arthritis and osteoartritis as a non- steroidal anti-inflammatory drug. In this
work, four different new methods, HPLC, HPTLC, 1H-NMR and LC/MS have been
developed and applied to commercial tablets. The results of all these four
different methods are compared and inter comparison of these results with
respect to sensitivity, ease of applicability and the coşt are made between
themselves. All these new methods developed are better and more sensitive than
UV methods used in routine analysis nowadays. İn this study, it is obviously
understood that the new techniques should be considered in controls and
registration of the drugs. It is necessary to make the analysis by using modern
techniques and to use new instrumentations to have more definite results in
quantitative analysis and to make easy analytic applications and to decrease
errors.

Keywords

Nabumetone, LC/MS, HPTLC, 1H-NMR

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