estudam public health journal

Eskişehir Türk Dünyası Uygulama ve Araştırma Merkezi Halk Sağlığı Dergisi

2564-6311 2564-6311

Eskişehir Osmangazi University

10.35232/estudamhsd.653993

Public Health Environmental Health

Halk Sağlığı Çevre Sağlığı

THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

GESTASYONEL HİPERTANSİF BOZUKLUKLAR ile TROMBOSİT BELİRTEÇLERİNİN İLİŞKİSİ / THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

https://orcid.org/0000-0002-0745-0907

Ekici

Mustafa Ayhan

ABANT IZZET BAYSAL UNIVERSITY

https://orcid.org/0000-0001-7493-5165

Kayhan

Mehmet

ABANT İZZET BAYSAL ÜNİVERSİTESİ

01 16 2020

5 1 121 130 12 02 2019

2016

ESTUDAM Public Health Journal

The aim of this study to evaluate relationship betweenthrombocyte indices, Red cell distribution width (RDW) and gestationalhypertensive disorders. This study is a retrospective cross sectional studyperformed between 2009 - 2019.Total 583 pregnant women were included in thisstudy; 123 severe preeclampsia (PE), 175 mild-PE, 73 gestational hypertension(GH), 41 chronic hypertension and 171 healthy pregnant women (control group).Statistical Package for Social Science version 23.0 is used for statisticalanalysis. Kolmogorov-Smirnov, Anova, Kruskal-Wallis and Mann Whitney U testsare used for interpretation of data. Statistical significance is considered ifp < 0.05. Mean age and number of pregancies were indifferent among fivegroups. Mean Platelet Volume (MPV) was significantly higher in severe-PE group(p<0.001) and insignificantly different among mild-PE, GH, chronichypertension and control groups (p=0.116) . Platelet count (PC) was foundsignificantly lower in severe-PE group (p=0.01) and found indifferent amongmild-PE, GH, chronic hypertension and control groups (p=0.110). RDW was foundsignificantly higher in severe-PE group than other groups (p=0.01)andsignificantly higher in mild-PE group than GH, chronic hypertension and controlgroups (p=0.01) but insignificantly different among GH, chronic hypertensionand control groups (p=0.501). Platelet distribution width (PDW) was foundsignificantly lower in control group than other groups (p<0.001) and foundindifferent among mild-PE, GH, chronic hypertension and severe-PE groups(p=0.621). Neutrophil lymphocyte ratio (NLR), hemoglobin, Plateletcrit andPlatelet lymphocyte ratio (PLR) were found unchanged among the groups. MPV,RDW, PDW, NLR, PC, Plateletcrit and PLR were indifferent among GH and chronichypertension groups. MPV and RDW were found higher and PC was found lower insevere-PE. RDW levels elevation was found higher in accordance with theseverity of preeclampsia. PDW was found higher in gestational hypertensivedisorders than healthy pregnant women.

Çalışmanın amacı trombosit indeksleri, eritrosit dağılım genişliği (RDW) ve gestasyonelhipertansif bozukluklar arasındaki ilişkiyi değerlendirmektir. Çalışma2009-2019 yılları arasında yapılan retrospektif kesitsel bir çalışmadır. Toplam583 hamile kadın çalışmaya dahil edildi; 123 şiddetli preeklampsi (PE), 175hafif PE, 73 gestasyonel hipertansiyon (GH), 41 kronik hipertansiyon ve 171sağlıklı gebe (kontrol grubu). Verilerin yorumlanmasında Kolmogorov-Smirnov,ANOVA, Kruskal-Wallis ve Mann Whitney U testleri kullanılmıştır. İstatistikselanlamlılık p <0.05 olduğunda kabul edildi. Ortalama yaş ve gebelik sayısıaçısından beş grup arasında fark bulunmadı. Ortalama Trombosit Hacmi (MPV)şiddetli PE grubunda anlamlı derecede yüksek (p <0.001) bulundu. Hafif PE,GH, kronik hipertansiyon ve kontrol grupları arasında MPV değerleri anlamlıderecede farklı değildi (p = 0.116). Trombosit sayısı (PC) şiddetli PE grubundaanlamlı olarak düşük bulundu (p = 0.01). Hafif PE, GH, kronik hipertansiyon vekontrol grupları arasında PC değerleri arasında anlamlı farlılık bulunmadı(p=0.110). RDW, şiddetli PE grubunda diğer gruplardan (p = 0.01), hafif PEgrubunda GH, kronik hipertansiyon ve kontrol gruplarından (p = 0.01) anlamlıolarak daha yüksek bulundu. Gestasyonel hipertansiyon, kronik hipertansiyon vekontrol grupları arasında RDW değerleri anlamlı derecede farklı bulunmadı. (p=0.501). Trombosit dağılım genişliği (PDW) kontrol grubunda diğer gruplara göreanlamlı olarak düşük bulundu (p <0.001). Hafif PE, GH, kronik hipertansiyonve şiddetli PE grupları arasında PDW değerleri arasında farklılık bulunmadı (p= 0.621). Nötrofil lenfosit oranı (NLR), hemoglobin, Trombosit ve Trombositlenfosit oranı (PLR) gruplar arasında farklılık göstermedi. MPV, RDW, PDW, NLR,PC, Trombosit ve PLR değerleri GH ve kronik hipertansiyon grupları arasındafarlılık göstermedi. Şiddetli PE'de MPV ve RDW daha yüksek ve PC daha düşükbulundu. Preeklempsi şiddeti arttıkça RDW düzeylerinde artış olmaktadır.Gestasyonel hipertansif hastalıklarda RDW seviyeleri sağlıklı gebelerden dahayüksek bulunmuştur.

Preeclampsia hypertension thrombocyte indices MPV PDW RDW NLR

Preeklampsi hipertansiyon trombosit indeksleri MPV PDW RDW NLR

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