Relationship of multiple myeloma with ABO blood groups

Year 2021, Volume: 60 Issue: 3, 274 - 280, 13.09.2021

Didar Yanardağ Açık Mehmet Bankir Begüm Şeyda Avci

https://doi.org/10.19161/etd.990715

Abstract

Aim: Multiple myeloma is a heterogeneous, incurable haematological cancer that occurs as a result of the clonal proliferation of plasma cells. The impact of blood groups on human diseases and/or their role in the prognosis of the disease has attracted the attention of scientists since the discovery of blood groups. We investigated the blood group distribution of multiple myeloma patients and whether their blood groups are related to immunoglobulin type.
Materials and Methods: 75 multiple myeloma patients and 73128 control group were included in the study, which was planned retrospectively. The statistical evaluation was performed by using Statistical Package for Social Sciences (SPSS) software for Windows 20 (IBM SPSS Inc., Chicago, IL). The normal distribution of the data was evaluated with the Kolmogorov-Smirnov test.
Results: In multiple myeloma patients, the rate of A and B blood groups was low, and the rate of O and AB blood groups was high. Heavy chain IgA ratio was higher in B blood group compared to other blood groups. On the other hand, IgG ratio was found higher in O blood group compared to other blood groups.
Conclusion: A relationship has been found between immunoglobulin type and blood types in multiple myeloma. More comprehensive studies are needed on this subject.

Keywords

multiple myeloma, ABO blood group, monoclonal gammopathy

Multipl miyelomun ABO kan grupları ile ilişkisi

Abstract

Amaç: Multipl myelom plazma hücrelerinin klonal proliferasyonu sonucu oluşan, heterojen, kür sağlanamayan hematolojik bir kanserdir. Kan gruplarının insan hastalıklarına katkısı ve/veya hastalık seyrindeki rolü kan gruplarının keşfinden bu yana bilim insanlarının ilgisini çekmiştir. Multipl myelom hastalarının kan grubu dağılımını ve kan gruplarının immunglobulin tipi ile ilişkisinin olup olmadığını araştırdık.
Gereç ve Yöntem: Retrospektif planlanan çalışmaya 75 multipl myelom hastası ve 73128 kontrol grubu dahil edildi. İstatistiksel değerlendirme Statistical Package for Social Sciences (SPSS) for Windows 20 (IBM SPSS Inc., Chicago, IL) programı kullanılarak yapıldı. Verilerin normal dağılımı Kolmogorov-Smirnov testi ile değerlendirildi.
Bulgular: Multipl myelom hastalarında A ve B kan grupları oranı düşük, O ve AB kan grupları oranı yüksek saptandı. B kan grubunda ağır zincir IgA oranı diğer kan gruplarına kıyasla daha yüksek saptandı. IgG oranı ise O kan grubunda diğer kan gruplarına kıyasla daha yüksek saptandı.
Sonuç: Multipl myelomda immunoglobulin tipi ile kan grupları arasında bir ilişki bulunmuştur. Bu konuda yapılacak daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

multipl myelom, ABO kan grubu, monoklonal gammopati

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