Comparison of clinicopathological and survival analysis of uterus confined carcinosarcoma and grade 3 endometrioid endometrium cancer

Year 2021, , 7 - 11, 28.03.2021

Caner Çakır , Vakkas Korkmaz , Çiğdem Kılıç , Dilek Yüksel , Mehmet Ünsal , Betül Tokgöz , Fatih Kılıç , Sevgi Koç , Fulya Kayıkçıoğlu , Taner Turan

https://doi.org/10.46969/ezh.753136

Abstract

Aim: Although Grade 3 endometrioid endometrial cancer (G3ECC) and carcinosarcomas (CS) are included in the same risk group among endometrial cancer cases in the consensus published by ESMO-ESGO-ESRTO in 2015, the biological behaviors of these histological types are different. In this study, we aimed to compare grade 3 endometrioid endometrial cancer cases with carcinosarcoma cases limited to the uterus in terms of clinical results and survival analysis.
Material and Methods: Grade 3 endometrioid endometrial cancer (G3 ECC) cases (n = 67) in which the disease is limited to the uterus and uterine limited CS cases (n = 54) were compared in terms of clinical results and survival analysis.
Results: Despite the limited disease in the uterus, survival was significantly worse in patients with carcinosarcoma. While recurrence was 10.5% in G3ECC, this rate was found as 27.8% in CS (p = 0.011).
Conclusion: Carcinosarcomas may have a worse prognosis than G3 endometrioid endometrial cancers even in the early stages.

Keywords

Endometrioid endometrium cancer, Grade 3, carcinosarcoma, high risk, endometrial cancer, recurrence

Uterusa sınırlı karsinosarkom ve grade 3 endometrioid endometrium kanserinin klinikopatolojik ve sağkalım analizlerinin karşılaştırılması

Abstract

Amaç: Grade 3 endometrioid endometrium kanseri (G3ECC) ve karsinosarkom (KS), ESMO-ESGO-ESRTO’un 2015’de yayınladığı konsensüsunda endometrium kanseri olguları içinde aynı risk grubunda yer alsa da, bu histolojik tiplerin biyolojik davranışları farklıdır. Bu çalışmada G3ECC olguları ile uterusa sınırlı KS vakalarının klinik sonuçlar ve sağkalım analizleri açısından karşılaştırılması amaçlandı.

Gereç ve Yöntem: Uterusa sınırlı hastalığı olan G3ECC olguları (n=67) ile uterusa sınırlı karsinosarkom (KS) olguları (n=54) klinik sonuçları ve sağkalım analizleri açısından karşılaştırıldı.

Bulgular: Uterusa sınırlı hastalık olmasına rağmen KS olan hastalarda sağkalımın belirgin kötü olduğu görüldü. Rekürrens G3ECC’de %10,5 iken, KS’da bu oran %27,8 olarak saptandı (p=0,011). 

Sonuç: Karsinosarkomlar erken evrede dahi G3 endometrioid endometrium kanserlerinden daha kötü prognoza sahip olabilirler. 

Keywords

Endometrioid endometrium kanseri, grade 3, karsinosarkom, yüksek risk, endometrial kanser, rekürrens

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