SHOULD SERUM FOLATE BE A ROUTINE TEST IN A CRITICALLY ILL PATIENTS?

Year 2024, Volume: 33 Issue: 3, 331 - 335

Zuhal Ozer Simsek , Kaniye Aydın , Ali Çetinkaya

https://doi.org/10.34108/eujhs.1194675

Abstract

In intensive care patients, there is an increased consumption and need for folate due to sepsis, comorbid conditions, and malnutrition. The aim of our study was planned to investigate the frequency of folate deficiency in intensive care patients. The data of the 100 patients was collected between June 2019 and September 2019. Serum folate levels were defined as normal above 4 ng/mL, 2-4 ng/mL borderline and below 2 ng/mL deficiency. Serum folate deficiency (<2 ng/mL) was detected in 19 patients (31.6% (6 patients) was female and 68.4% (13 patients) was male. Hypertension was most frequently comorbidities together with folate deficiency. There was a significant negative correlation between folate levels and "Acute Physiology and Chronic Health Evaluation (APACHE)" II scores. A high APACHE II score may be an important predictive factor for folate deficiency. Current reference ranges may cause folate malnutrition. For intensive care patients, it may be necessary to set new threshold values for folate deficiency.

Keywords

APACHE II, folic acid deficiency, intensive care unit

SERUM FOLAT KRİTİK HASTALARDA RUTİN BİR TEST OLMALI MI?

Abstract

Yoğun bakım hastalarında sepsis, komorbid durumlar, malnütrisyon gibi nedenlerle artan folat tüketimi ve ihtiyacı vardır. Çalışmamız yoğun bakım hastalarında folat eksikliğinin sıklığını araştırmak amacıyla planlandı. Yüz hastanın verileri Haziran 2019 ile Eylül 2019 arasında toplandı. Serum folat düzeyleri 4 ng/mL üzeri normal, 2-4 ng/mL sınırda ve 2 ng/mL altı eksiklik olarak tanımlandı. Serum folat eksikliği (<2 ng/mL) 19 hastada (%31.6 (6 hasta) kadın, %68.4 (13 hasta) erkek saptandı. Hipertansiyon folat eksikliğine en sık eşlik eden komorbid hastalıktı. Folat düzeyleri ile "Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi (APACHE)" II puanları arasında anlamlı negatif korelasyon vardı. Yüksek APACHE II skoru, folat eksikliği için önemli bir öngörücü faktör olabilir. Mevcut referans aralıkları folat malnütrisyonuna neden olabilir. Yoğun bakım hastaları için folat eksikliği için yeni eşik değerlerin belirlenmesi gerekebilir.

Keywords

APACHE II, folik asit eksikliği, yoğun bakım ünitesi

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