Epidemiologic, clinical findings and risk factors of recurrent herpes labialis in healthy adult patients: a case-control study

Year 2019, , 545 - 549, 04.05.2019

Mohammad Nassaji , Raheb Ghorbani Ramin Taheri Maryam Azizzadeh Fatemeh Abbassyan

https://doi.org/10.18621/eurj.384806

Cited By: 1

Abstract

Objectives: Herpes labialis is a common viral infection and
characterized by recurrent vesicular lesion primarily on the lips and perioral
skin. The
aim of this study was to determine the epidemiological, clinical characteristics and trigger
factors associated with recurrence
herpes labialis
in adult patients.

Methods:
This case-control study was
conducted with the participation of one hundred adult patients and the same
number of control. Data collected about demographics, clinical, as well as
trigger factors from individuals
who met inclusion criteria.

Results:
Seventy-four percent of cases and 34% of controls were female that showed
significant difference (p <
0.001). Mean body mass index of patients was significantly higher than controls
(25.9 ± 2.9 kg/m² versus 22.0 ± 2.9 kg/m², p < 0.001). The most common location of the
lesions during the last episode of infection was upper lip (65%). The number of lesions was single
in 58% and multiple in 42% of patients. The frequency of
episodes per year was more than two attacks each year in most patients (83%). Positive family history of recurrence
herpes labialis
was found in 50% and 20% of cases and controls respectively (p < 0.001). Emotional stress (61%), sunlight exposure (54%) and flu
(37%)
were the main triggering factors reported by the patients.

Conclusions: This study revealed that recurrence herpes
labialis is more common in women and on the upper lip. Family history of recurrence herpes
labialis was positive significantly in patients. The most common trigger
factors were stress,
sunlight exposure, flu. Higher body mass index was a probable risk factors for recurrence herpes
labialis. 

Keywords

Recurrence herpes labialis, adult, epidemiology, trigger factors

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