Research Article
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The relationship between epicardial fat volume and myocardial perfusion scintigraphy findings

Year 2023, 1 - 7, 31.12.2023
https://doi.org/10.18621/eurj.1084333

Abstract

Objectives: We investigated the epicardial fat volume (EFV) between patients with normal perfusion and reversible perfusion abnormalities in the myocardial perfusion scintigraphy (MPS) in patients with suspected coronary artery disease (CAD). In addition, we aimed to investigate the relationship of automated analysis parameters obtained in the MPS SPECT examination with EFV.

Methods: A total of 295 patients (182 F, 113 M) who underwent MPS in our unit with the suspicion of CAD in the last 1 year and who had a recent thorax CT examination were included. EFV measurement in CT scans was done with Invesalius software. MPS was performed in all patients with a one-day stress and rest imaging protocol. In the stress study, imaging was performed approximately 30-45 minutes after intravenous injection of ~12 mCi Tc99m Sestamibi. Rest study imaging was performed approximately 30-60 minutes after intravenous injection of ~25 mCi Tc99m Sestamibi.

Results: Median EFV was 53.00 ml (interquartile range: 23 ml, range 17-238 ml) in patients with normal MPS, and 62.00 ml in patients with myocardial ischemia on scintigraphy (interquartile range: 53 ml, range: 25-207 ml). The EFV value was statistically significantly higher in patients with reversible ischemia on MPS compared to patients with normal scintigraphy findings (p < 0.001). There was a statistically significant, low, and positive correlation between EFV and summed difference score (SDS) values (p = 0.002, r = 0.178).

Conclusions: The EFV value was significantly higher in patients with reversible ischemia on MPS compared to patients with normal scintigraphy findings. Also there was a statistically low and positive correlation between EFV and SDS values. The automatic calculation of the EFV value during this examination may be a good additional parameter to detect the presence of ischemia.

References

  • 1. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1459-544.
  • 2. Milanese G, Silva M, Ledda RE, Goldoni M, Nayak S, Bruno L, et al. Validity of epicardial fat volume as biomarker of coronary artery disease in symptomatic individuals: results from the ALTER-BIO registry. Int J Cardiol 2020;314:20-4.
  • 3. Konishi M, Sugiyama S, Sato Y, Oshima S, Sugamura K, Nozaki T, et al. Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 2010;213:649-55.
  • 4. Iacobellis G, Sharma AM. Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr Pharm Des 2007;13:2180-4.
  • 5 Sabharwal NK, Lahiri A. Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease. Heart 2003;89:1291-7.
  • 6. Kilambi Y, Halanaik D, Ananthakrishnan R, Mishra J. Comparison of epicardial fat volume between patients with normal perfusion and reversible perfusion abnormalities on myocardial perfusion imaging. Indian J Nucl Med 2021;36:1-6.
  • 7. Khawaja T, Greer C, Thadani SR, Kato TS, Bhatia K, Shimbo D, et al. Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease. J Nucl Cardiol 2015;22:325-33.
  • 8. Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging 2010;3:1104-12.
  • 9. Janik M, Hartlage G, Alexopoulos N, Mirzoyev Z, McLean DS, Arepalli CD, et al. Epicardial adipose tissue volume and coronary artery calcium to predict myocardial ischemia on positron emission tomography-computed tomography studies. J Nucl Cardiol 2010;17:841-7.
  • 10. Otaki Y, Hell M, Slomka PJ, Schuhbaeck A, Gransar H, Huber B, et al. Relationship of epicardial fat volume from noncontrast CT with impaired myocardial flow reserve by positron emission tomography. J Cardiovasc Comput Tomogr 2015;9:303-9.
  • 11. Yu W, Liu B, Zhang F, Wang J, Shao X, Yang X, et al. Association of epicardial fat volume with increased risk of obstructive coronary artery disease in Chinese patients with suspected coronary artery disease. J Am Heart Assoc 2021;10:e018080.
  • 12. Sun DF, Kangaharan N, Costello B, Nicholls SJ, Emdin CA, Tse R, et al. Epicardial and subcutaneous adipose tissue in indigenous and non-indigenous individuals: implications for cardiometabolic diseases. Obes Res Clin Pract 2020;14:99-102.
  • 13. Moharram MA, Aitken-Buck HM, Reijers R, van Hout I, Williams MJA, Jones PP, et al. Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. NZ Med J 2020;133:22-32.

Year 2023, 1 - 7, 31.12.2023
https://doi.org/10.18621/eurj.1084333

Abstract

References

  • 1. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1459-544.
  • 2. Milanese G, Silva M, Ledda RE, Goldoni M, Nayak S, Bruno L, et al. Validity of epicardial fat volume as biomarker of coronary artery disease in symptomatic individuals: results from the ALTER-BIO registry. Int J Cardiol 2020;314:20-4.
  • 3. Konishi M, Sugiyama S, Sato Y, Oshima S, Sugamura K, Nozaki T, et al. Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 2010;213:649-55.
  • 4. Iacobellis G, Sharma AM. Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr Pharm Des 2007;13:2180-4.
  • 5 Sabharwal NK, Lahiri A. Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease. Heart 2003;89:1291-7.
  • 6. Kilambi Y, Halanaik D, Ananthakrishnan R, Mishra J. Comparison of epicardial fat volume between patients with normal perfusion and reversible perfusion abnormalities on myocardial perfusion imaging. Indian J Nucl Med 2021;36:1-6.
  • 7. Khawaja T, Greer C, Thadani SR, Kato TS, Bhatia K, Shimbo D, et al. Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease. J Nucl Cardiol 2015;22:325-33.
  • 8. Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging 2010;3:1104-12.
  • 9. Janik M, Hartlage G, Alexopoulos N, Mirzoyev Z, McLean DS, Arepalli CD, et al. Epicardial adipose tissue volume and coronary artery calcium to predict myocardial ischemia on positron emission tomography-computed tomography studies. J Nucl Cardiol 2010;17:841-7.
  • 10. Otaki Y, Hell M, Slomka PJ, Schuhbaeck A, Gransar H, Huber B, et al. Relationship of epicardial fat volume from noncontrast CT with impaired myocardial flow reserve by positron emission tomography. J Cardiovasc Comput Tomogr 2015;9:303-9.
  • 11. Yu W, Liu B, Zhang F, Wang J, Shao X, Yang X, et al. Association of epicardial fat volume with increased risk of obstructive coronary artery disease in Chinese patients with suspected coronary artery disease. J Am Heart Assoc 2021;10:e018080.
  • 12. Sun DF, Kangaharan N, Costello B, Nicholls SJ, Emdin CA, Tse R, et al. Epicardial and subcutaneous adipose tissue in indigenous and non-indigenous individuals: implications for cardiometabolic diseases. Obes Res Clin Pract 2020;14:99-102.
  • 13. Moharram MA, Aitken-Buck HM, Reijers R, van Hout I, Williams MJA, Jones PP, et al. Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. NZ Med J 2020;133:22-32.

Details

Primary Language English
Subjects Radiology, Nuclear Medicine, Medical Imaging
Journal Section Original Articles
Authors

Süleyman ÖNCÜ> (Primary Author)
Department of Radiology, Tokat State Hospital, Tokat, Turkey
0000-0002-1434-3536
Türkiye


Seyit Ahmet ERTÜRK>
Department of Nuclear Medicine, Tokat State Hospital, Tokat, Turkey
0000-0002-6030-9662
Türkiye

Publication Date December 31, 2023
Submission Date March 8, 2022
Acceptance Date April 21, 2022
Published in Issue Year 2023, Volume , Issue

Cite

EndNote %0 The European Research Journal The relationship between epicardial fat volume and myocardial perfusion scintigraphy findings %A Süleyman Öncü , Seyit Ahmet Ertürk %T The relationship between epicardial fat volume and myocardial perfusion scintigraphy findings %D 2023 %J The European Research Journal %P -2149-3189 %V %N %R doi: 10.18621/eurj.1084333 %U 10.18621/eurj.1084333

e-ISSN: 2149-3189 


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