Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis

Year 2019, Volume: 5 Issue: 1, 159 - 165, 04.01.2019

Kadir Kaan Özsin , Umut Serhat Sanrı , Faruk Toktaş , İbrahim Burak Şeker Şenol Yavuz

https://doi.org/10.18621/eurj.444384

Abstract

Objectives: We
aim to evaluate the relationship between serum lipid indices and carotid artery
stenosis (CAS).

Methods: This
retrospective observational study included patients who underwent carotid
endarterectomy (CEA) and unoperated patients who have CAS less than 50%. CAS
was diagnosed with history and physical examination followed by doppler ultrasonography,
coronary and carotid angiography. All data retrieved retrospectively from the
hospital medical files. Non-high-density lipoprotein-cholesterol (non-HDL-C)
level was calculated by removing HDL-C from total cholesterol. In addition,
low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio, non-HDL-C/HDL-C ratio,
and triglyceride (TG)/HDL-C ratio were assessed.

Results: CEA group
(77.5% male, mean age: 71.35 ± 8.35 years) included 40 patients who underwent CEA,
and there were 32 patients who have less than 50% CAS in unoperated group (68.8%
male, mean age: 63.94 ± 9.92 years). The development of CAS was not
significantly correlated with LDL-C/HDL-C ratio (p = 0.119), non-HDL-C/HDL-C ratio (p = 0.227) and TG/HDL-C ratio (p
= 0.768). Advanced age and presence of coronary artery disease were
identified as an independent predictor of the development of CAS. For
predicting development of CAS, there were 50.0% sensitivity and 65.6%
specificity for LDL-C/HDL-C ratio and non-HDL-C/ HDL-C ratio (area under the
curve [AUC]: 0.592, log rank p = 0.183,
AUC: 0.583, log rank p = 0.227,
respectively).

Conclusions: We
found that lipid ratios were not an independent predictors of the development
of CAS. But, we think that AUC values which were above 0.5 for lipid ratios are
may be important development of CAS. 

Keywords

Carotid artery stenosis, lipid levels, disease progression

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