Effects of GDF-15 Level in Patients with Membranous Nephropathy

Year 2024, Volume: 14 Issue: 1, 40 - 45, 24.04.2024

Aıda Adıkozalova Sebahat Usta Akgül Erol Demir Hayriye Şentürk Çiftçi Fatma Savran Oğuz Halil Yazıcı Çiğdem Kekik Çınar

https://doi.org/10.26650/experimed.1403563

Abstract

Objective: Nephrotic syndrome is the most frequent cause of membranous nephropathy (MN) in adults. Growth differentiation factor (GDF)-15 is a cytokine released under stress and associated with increased incidence of chronic kidney disease and/or decreased renal function in conditions such as diabetic nephropathy, IgA nephropathy, lupus nephritis, and primary MN. The diagnosis of MN is made by biopsy, which is an invasive procedure. A non-invasive biomarker is needed for timely and risk-free diagnosis. This study aimed to estimate the GDF-15 level in patients with MN to determine if it can be used as a noninvasive biomarker for the diagnosis of MN.

Materials and Methods: The study included 88 patients with MN. Sera were obtained from peripheral blood collected from the patients. GDF-15 levels were analyzed using enzyme-linked immunosorbent assay (ELISA).

Results: GDF-15 level was high in older patients that in younger patients. The glomerular filtration rate was low in patients with increased GDF-15 levels. Furthermore, a decrease in GDF-15 levels was observed in patients in remission.

Conclusion: GDF-15 level may be used as a biomarker to predict the progression of MN rather than a diagnostic biomarker.

Keywords

Membranous nephropathy, GDF-15, ELISA

Ethical Statement

This study was approved by the clinical experiments local ethical committee of Istanbul University Istanbul Faculty of Medicine (date: 03/10/2018, number: 2018/1260).

Supporting Institution

The study was supported by the approval of the Istanbul University Scientific Research and Project (BAP) commission with code number TYL-2018-32358.

Project Number

32358

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