farabi med j

Farabi Tıp Dergisi

2979-9821

Karadeniz Technical University

10.59518/farabimedj.1572593

Metabolic Medicine

Metabolik Tıp

An Important Adipokine: Isthmin-1

Önemli Bir Adipokin: İstmin-1

https://orcid.org/0000-0001-5558-9500

Ameen Muhammed Saeed Aledresi

Kawther

KARADENIZ TECHNICAL UNIVERSITY

https://orcid.org/0000-0003-0730-9660

Kural

Birgül

KARADENİZ TEKNİK ÜNİVERSİTESİ

https://orcid.org/0000-0001-6935-2889

Kör

Sevil

KARADENIZ TECHNICAL UNIVERSITY

03 30 2025

4 1 12 16 10 23 2024 11 30 2024

2022

Farabi Tıp Dergisi

The presence of isthmin-1 in different body compartments reveals its significance in metabolism, cell proliferation, endothelial permeability, angiogenesis and immunity. Studies have categorized isthmin-1 as an adipokine with insulin-like behavior that uptakes glucose by the adipocytes and inhibits liver steatosis through a not identified tyrosine kinase receptor, that it is distinct from insulin receptor. Additionally, this adipokine demonstrates important functions in regulating organs development and homeostasis. This review aims to summarize the informations of isthmin-1 protein mainly its functions on glucose and lipid metabolisms.

İsthmin-1'in farklı vücut bölmelerinde bulunması metabolizma, hücre çoğalması, endotel geçirgenliği, anjiyogenez ve immünitedeki önemini ortaya koymaktadır. Çalışmalar isthmin-1'i, adipositler tarafından glukozu alan ve bilinmeyen bir reseptör aracılığıyla karaciğer yağlanmasını engelleyen insülin benzeri davranışa sahip bir adipokin olarak kategorize etmiştir. Ek olarak, bu adipokin organ gelişimini ve homeostazisini düzenlemede önemli işlevler göstermektedir. Bu derleme, isthmin-1 proteininin esas olarak glukoz ve lipid metabolizmaları üzerindeki işlevleri hakkındaki bilgileri özetlemeyi amaçlamaktadır.

Adipokine Glucose and lipid metabolism Isthmin-1

Adipokin Glukoz ve lipid metabolizması İstmin-1

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