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The Incidence of Histopathologic Diagnosis in Hysterectomy Specimens

Year 2012, Volume: 17 Issue: 1, 19 - 22, 01.02.2012

Abstract

Objective: This study identified the frequency of clinical indications for hysterectomy and the most common pathologies in hysterectomy specimens. Material and Methods: A total of 361 hysterectomy specimens between October 2007 and October 2009 were retrieved and studied Results: The most common indication for hysterectomy was leiomyoma (31.85 %). Other indications were endometrial hyperplasia (27.14 %), dysfunctional uterine bleeding (18.55 %), uterine prolapse (9.14 %), chronic pelvic pain (7.20 %), adenomiyosis (3.87 %), cervical neoplasia (2.21 %). The most common pathology identified was leiomyoma (40.16 %). Other pathologies included endometrial hyperplasia (38.22 %), adenomyosis (25.48 %), endometrial polyps (8.86 %), CIN 1 (3.32 %), CIN 2 (1.66 %) and atrophic endometrium (3.60 %). In 158 (43.76 %) of hysterectomy specimens combined pathology was identified. The most common combination was leiomyoma and endometrial hyperplasia (38.60%). Other combined pathologies included adenomoysis and endometrial polyps (17.72 %), adenomyosis and leiomyoma (12.65 %), leiomyoma and endometrial polyps (8.22 %). Conclusion: The existence of cervical disorders should be demonstrated when an operation is going to be performed for an endometrial pathology in a pre or postmenopausal woman. Cervix and cervical canal should be examined during endometrial evaluation.

References

  • Lee NC, Dicker RC, Rubin GL, Ory HW. Confirmation of the preoperative diagnoses for hysterectomy. Am J Obstet Gynecol 1984; 150: 283-287.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312-322.
  • Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 2009; 280: 529-538.
  • Bird CC, McElin TW, Manalo-Estrella P. The elusive adenomyosis of the uterus-revisited. Am J Obstet Gynecol 1972; 112: 583-593.
  • K. Jo. Adenomyosis: the pathophysiology of an oestrogen- dependent disease. Best Pract Res Clin Obstet Gynecol 2006; 20: 493-502.
  • Atri M, Reinhold C, Mehio AR, Chapman WB, Bret PM. Adenomyosis: US features with histologic correlation in an in vitro study. Radiology 2000; 215: 783-790.
  • Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review.Environ Health Perspect 2003; 111: 1037- 1054.
  • Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In: Kurman RJ, editor. Blaunstein’s pathology of the female genital tract. 5. edition. New York: Springer, 2002; 421–466.
  • Perez-Medina T, Martinez O, Folgueira G, Bjo J. Which endometrial polyps should be resected? J Am Assoc Gynecol Laparosc 1999; 6: 71-74.
  • Reslova T, Tosner J, Resl M, Kugler R, Vavrova I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999; 262: 133-139.
  • Talukder SI, Haque MA, Hug MH, Alam MO, Roushan A, Noor Z, et al. Histopathological analysis of hysterectomy specimens. Mymensing Med J 2007; 16: 81-84.
  • Bukhari U, Sadiq S. Analysis of the underlying pathological lesions in hysterectomy specimens. Pak J Pathol 2007; 18: 110-112.
  • Verit FF, Artuc H, Kafalı H. The evaluation Of Simple Hysterectomies At Harran University Department Of Obstetrics And Gynecology. Türkiye Klinikleri J Gynecol Obst 2006; 16: 77-81.
  • Sutton GP, Brill L. Malignant papillary lesion of the endometrium. Gynecol Oncol 1987; 27: 294-304.
  • Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long term study of 'untreated' hyperplasia in 170 patients. Cancer 1985; 56: 403-412.
  • Tabata T, Yamawaki T, Yabana T, Ida M, Nishimura K, Nose Y. Natural history of endometrial hyperplasia: study of 77 patients. Arch Gynecol Obstet 2001; 265: 85-88.
  • Janicek MF, Rosenshein NB. Invasive endometrial cancer in uteri resected for atypical endometrial hyperplasia. Gynecol Oncol 1994; 52: 373-378.
  • Gönderilme Tarihi: 08.08.2011

Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı

Year 2012, Volume: 17 Issue: 1, 19 - 22, 01.02.2012

Abstract

Amaç: Bu çalışmada histerektomi için klinik endikasyonların sıklığı ve histerektomi materyallerindeki en yaygın patolojiler tanımlandı. Gereç ve Yöntem: Ekim 2007 ile Ekim 2009 arasında 361 histerektomi materyali tekrar gözden geçirildi ve patolojik tanılar araştırıldı. Bulgular: Histerektomi için en yaygın klinik endikasyon leiomyoma (% 31.85) idi. Diğer klinik endikasyonlar endometrial hiperplazi (% 27.14), disfonksiyonel uterin kanama (% 18.55), uterus prolapsusu (% 9.14), kronik pelvik ağrı (% 7.20), adenomyozis (% 3.87), servikal neoplazi (% 2.21) idi. En yaygın tanımlanan patoloji leiomyoma (% 40.16) idi. Diğer patolojiler endometrial hiperplazi (% 38.22), adenomyozis (% 25.48), endometrial polipler (% 8.86), CIN 1 ( % 3.32 ), CIN 2 ( % 1.66 ) ve atrofik endometrium (% 3.60) idi. Yüzellisekiz (% 43.76) histerektomi materyalinde kombine patolojiler tanımlandı. En yaygın kombinasyon leiomyoma ve endometrial hiperplazi (% 38.60) idi. Diğer kombine patolojiler adenomyozis ve endometrial polip (% 17.72), adenomyozis ve leiomyoma (% 12.65), leiomyoma ve endometrial polipler (% 8.22) idi. Sonuç: Endometrial patolojiler nedeniyle özellikle premenapozal ve postmenapozal dönemde opere edilecek olgularda servikal neoplazilerin beraber olabileceği unutulmamalıdır. Bu nedenle endometrial örnekleme yaparken endoservikal örneklemeninde yapılması önemlidir.

References

  • Lee NC, Dicker RC, Rubin GL, Ory HW. Confirmation of the preoperative diagnoses for hysterectomy. Am J Obstet Gynecol 1984; 150: 283-287.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312-322.
  • Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 2009; 280: 529-538.
  • Bird CC, McElin TW, Manalo-Estrella P. The elusive adenomyosis of the uterus-revisited. Am J Obstet Gynecol 1972; 112: 583-593.
  • K. Jo. Adenomyosis: the pathophysiology of an oestrogen- dependent disease. Best Pract Res Clin Obstet Gynecol 2006; 20: 493-502.
  • Atri M, Reinhold C, Mehio AR, Chapman WB, Bret PM. Adenomyosis: US features with histologic correlation in an in vitro study. Radiology 2000; 215: 783-790.
  • Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review.Environ Health Perspect 2003; 111: 1037- 1054.
  • Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In: Kurman RJ, editor. Blaunstein’s pathology of the female genital tract. 5. edition. New York: Springer, 2002; 421–466.
  • Perez-Medina T, Martinez O, Folgueira G, Bjo J. Which endometrial polyps should be resected? J Am Assoc Gynecol Laparosc 1999; 6: 71-74.
  • Reslova T, Tosner J, Resl M, Kugler R, Vavrova I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999; 262: 133-139.
  • Talukder SI, Haque MA, Hug MH, Alam MO, Roushan A, Noor Z, et al. Histopathological analysis of hysterectomy specimens. Mymensing Med J 2007; 16: 81-84.
  • Bukhari U, Sadiq S. Analysis of the underlying pathological lesions in hysterectomy specimens. Pak J Pathol 2007; 18: 110-112.
  • Verit FF, Artuc H, Kafalı H. The evaluation Of Simple Hysterectomies At Harran University Department Of Obstetrics And Gynecology. Türkiye Klinikleri J Gynecol Obst 2006; 16: 77-81.
  • Sutton GP, Brill L. Malignant papillary lesion of the endometrium. Gynecol Oncol 1987; 27: 294-304.
  • Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long term study of 'untreated' hyperplasia in 170 patients. Cancer 1985; 56: 403-412.
  • Tabata T, Yamawaki T, Yabana T, Ida M, Nishimura K, Nose Y. Natural history of endometrial hyperplasia: study of 77 patients. Arch Gynecol Obstet 2001; 265: 85-88.
  • Janicek MF, Rosenshein NB. Invasive endometrial cancer in uteri resected for atypical endometrial hyperplasia. Gynecol Oncol 1994; 52: 373-378.
  • Gönderilme Tarihi: 08.08.2011
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Remzi Atılgan This is me

Abdullah Boztosun This is me

Mehmet Reşat Özercan This is me

Publication Date February 1, 2012
Published in Issue Year 2012 Volume: 17 Issue: 1

Cite

APA Atılgan, R., Boztosun, A., & Özercan, M. R. (2012). Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı. Fırat Tıp Dergisi, 17(1), 19-22.
AMA Atılgan R, Boztosun A, Özercan MR. Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı. Fırat Tıp Dergisi. February 2012;17(1):19-22.
Chicago Atılgan, Remzi, Abdullah Boztosun, and Mehmet Reşat Özercan. “Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı”. Fırat Tıp Dergisi 17, no. 1 (February 2012): 19-22.
EndNote Atılgan R, Boztosun A, Özercan MR (February 1, 2012) Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı. Fırat Tıp Dergisi 17 1 19–22.
IEEE R. Atılgan, A. Boztosun, and M. R. Özercan, “Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı”, Fırat Tıp Dergisi, vol. 17, no. 1, pp. 19–22, 2012.
ISNAD Atılgan, Remzi et al. “Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı”. Fırat Tıp Dergisi 17/1 (February 2012), 19-22.
JAMA Atılgan R, Boztosun A, Özercan MR. Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı. Fırat Tıp Dergisi. 2012;17:19–22.
MLA Atılgan, Remzi et al. “Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı”. Fırat Tıp Dergisi, vol. 17, no. 1, 2012, pp. 19-22.
Vancouver Atılgan R, Boztosun A, Özercan MR. Histerektomi Materyallerinde Histopatolojik Tanıların İnsidansı. Fırat Tıp Dergisi. 2012;17(1):19-22.