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Laryngopharyngeal Reflux in Childhood

Year 2011, Volume: 16 Issue: 1, 1 - 5, 01.02.2011

Meltem Uğraş Yaşar Doğan

Abstract

Laryngopharyngeal reflux (LPR), is a recently recognized and investigated disease. Although there are many reports and studies about LPR in adults, there are not many in children. LPR occurs when gastric contents reflux beyond the esophagus to oropharynx and/or nasopharynx, producing symptoms and tissue damage. It has a wide clinical spectrum ranging from cough to apnea and appearent life treatening event. First of all, diagnosis needs recognition, then appropriate tests should be performed . Treatment depends on the severity of symptoms, disease and existence of underlying disease. LPR, should be sought among children with chronic cough, apnea, recurrent respiratory system infections, and managed by pediatric gastroenterology and ENT departments.

Keywords

-

References

  • Wenzl TG, Schenke S, Peschgens T, Silny J. Association of apnea and nonacid gastroesophageal reflux in children: investigations with the intraluminal impedance technique. Pedi- atr. Pulmonol 2001; 31: 144-149.
  • Mousa H, Woodley FW, Metheney M, Hayes J. Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr 2005; 41: 169-177.
  • McGuirt Jr WF. Gastroesophageal reflux and the upper airway. Pediatr Clin North Am 2003; 50: 487-502.
  • Carr MM, Poje CP, Ehrig D, Brodsky LS. Incidence of reflux in young children undergoing adenoidectomy. Laryngoscope 2001; 111: 2170-2172.
  • Keles B, Ozturk K, Arbag H, Gunel E, Ozer B. Frequency of pharyngeal reflux in children with adenoid hyperplasia. Int J Pe- diatr Otorhinolaryngol 2005; 69: 1103-1107.
  • Gumpert L, Kalach N, Dupont C, Contencin P. Hoarseness and gastroesophageal reflux in children. J Laryngol Otol 1998; 112: 49-54.
  • Bach KK, McGuirt WF Jr, Postma GN. Pediatric laryngopharyngeal reflux. Ear Nose Throat J 2002; 81: 27-31.
  • Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg 2000; 126: 831-836.
  • Sifrim D, Dupont L, Blondeau K, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 2005; 54: 449-454.
  • Poelmans J, Tack J, Feenstra L. Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux? Dig Dis Sci 2004; 49: 1868-1874.
  • Tasker A, Dettmar PW, Panetti M, et al. Is gastric reflux a cause of otitis media with effusion in children?. Laryngoscope 2002; 112: 1930-1934.
  • Tasker A, Dettmar PW, Panetti M. Reflux of gastric juice and glue ear in children [letter]. Lancet 2002; 359: 49.
  • Thach BT. Sudden infant death syndrome: can gastroesophageal reflux cause sudden infant death? Am J Med 2000; 108: 144-148.
  • Duke SG, Postma GN, McGuirt WF, et al. Laryngospasm and Diaphragmatic Arrest in Immature Dogs After Laryngeal Acid Exposure. Ann Otol Rhinol Laryngol 2001; 110: 729-733.
  • Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002; 16: 274-277.
  • Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001; 111: 1313-1317.
  • Mahajan L, Wyllie R, Oliva L, et al. Reproducibility of 24-hour intraesophageal pH monitoring in pediatric patients. Pediatrics 1998; 101: 260-263.
  • Little JP, Matthews BL, Glock MS, et al. Extraesophageal pediatric reflux: 24-hour double-probe pH monitoring of 222 children. Ann Otol Rhinol Laryngol Suppl 1997; 169: 1-16.
  • McMurray JS, Gerber M, Stern Y, et al. Role of laryngoscopy, dual pH probe monitoring, and laryngeal mucosal biopsy in the diagnosis of pharyngoesophageal reflux. Ann Otol Rhinol Laryngol 2001; 110: 299-304.
  • Ugras M, Ertem D, Cam S, Tutar E, Pehlivanoglu E. Can gastro- oesophageal reflux be predicted while advancing the endoscope through the laryngeal area? Gut 2005; 54: 890-891.
  • Aviv JE, Martin JH, Kim T, et al. Laryngopharyngeal sensory discrimination testing and the laryngeal adductor reflex.. Ann Otol Rhinol Laryngol 1999; 108: 725-730.
  • Rudolph CD, Mazur LJ, Liptak GS, et al.. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 2001; 32: 1-31.
  • Faure C, Michaud L, Shaghaghi EK, et al. Lansoprazole in children: pharmacokinetics and efficacy in reflux oesophagitis. Aliment Pharmacol Ther 2001; 15: 1397-1402.
  • Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. International Pediatric Omeprazole Study Group. J Pediatr 2000; 137: 800- 807.
  • Suskind DL, Zeringue GP 3rd, Kluka EA, Udall J, Liu DC.Gastroesophageal reflux and pediatric otolaryngologic disease: the role of antireflux surgery. Arch Otolaryngol Head Neck Surg 2001; 127: 511-514.
  • Hassall E. Decisions in diagnosing and managing chronic gastroesophageal reflux disease in children. J Pediatr 2005; 146: 3-12.
  • Kabul Tarihi: 11.03.2011

Çocukluk Çağında Laringofaringeal Reflü

Year 2011, Volume: 16 Issue: 1, 1 - 5, 01.02.2011

Meltem Uğraş Yaşar Doğan

Abstract

Laringofarengeal reflü (LFR), son yıllarda giderek daha çok tanınan ve araştırılan bir hastalıktır. Yetişkinlerde bu konu ile ilgili çok sayıda yayın olmakla birlikte çocuklarda daha az çalışma mevcuttur. LFR, gastroözofageal reflünün üst özofagus sfinkterinin yukarısında kalan yapıları etkilemesi sonucu ortaya çıkan bir durumdur. Klinikte kronik öksürükten apne ve hayatı tehdit eden akut olaylara kadar değişen geniş bir semptom yelpazesine sahiptir. Tanıda öncelikle LFR'den şüphelenilmesi ve hasta ve bulgularına yönelik tetkikler yapılması gereklidir. Tedavi hastalık ağırlığına, altta yatan hastalıkların varlığına göre planlanmaktadır. LFR, kronik öksürük, apne, hırıltı tekrarlayan solunum yolu enfeksiyonlarında çocuklarda düşünülmesi gereken, Pediatrik Gastroenteroloji ve Kulak Burun Boğaz bölümleri ile koordineli olarak takip gerektirmekte olup uygun tedavi ile düzelen bir hastalıktır.

Keywords

Reflü özofagus larinks çocuk

References

  • Wenzl TG, Schenke S, Peschgens T, Silny J. Association of apnea and nonacid gastroesophageal reflux in children: investigations with the intraluminal impedance technique. Pedi- atr. Pulmonol 2001; 31: 144-149.
  • Mousa H, Woodley FW, Metheney M, Hayes J. Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr 2005; 41: 169-177.
  • McGuirt Jr WF. Gastroesophageal reflux and the upper airway. Pediatr Clin North Am 2003; 50: 487-502.
  • Carr MM, Poje CP, Ehrig D, Brodsky LS. Incidence of reflux in young children undergoing adenoidectomy. Laryngoscope 2001; 111: 2170-2172.
  • Keles B, Ozturk K, Arbag H, Gunel E, Ozer B. Frequency of pharyngeal reflux in children with adenoid hyperplasia. Int J Pe- diatr Otorhinolaryngol 2005; 69: 1103-1107.
  • Gumpert L, Kalach N, Dupont C, Contencin P. Hoarseness and gastroesophageal reflux in children. J Laryngol Otol 1998; 112: 49-54.
  • Bach KK, McGuirt WF Jr, Postma GN. Pediatric laryngopharyngeal reflux. Ear Nose Throat J 2002; 81: 27-31.
  • Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg 2000; 126: 831-836.
  • Sifrim D, Dupont L, Blondeau K, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 2005; 54: 449-454.
  • Poelmans J, Tack J, Feenstra L. Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux? Dig Dis Sci 2004; 49: 1868-1874.
  • Tasker A, Dettmar PW, Panetti M, et al. Is gastric reflux a cause of otitis media with effusion in children?. Laryngoscope 2002; 112: 1930-1934.
  • Tasker A, Dettmar PW, Panetti M. Reflux of gastric juice and glue ear in children [letter]. Lancet 2002; 359: 49.
  • Thach BT. Sudden infant death syndrome: can gastroesophageal reflux cause sudden infant death? Am J Med 2000; 108: 144-148.
  • Duke SG, Postma GN, McGuirt WF, et al. Laryngospasm and Diaphragmatic Arrest in Immature Dogs After Laryngeal Acid Exposure. Ann Otol Rhinol Laryngol 2001; 110: 729-733.
  • Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002; 16: 274-277.
  • Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001; 111: 1313-1317.
  • Mahajan L, Wyllie R, Oliva L, et al. Reproducibility of 24-hour intraesophageal pH monitoring in pediatric patients. Pediatrics 1998; 101: 260-263.
  • Little JP, Matthews BL, Glock MS, et al. Extraesophageal pediatric reflux: 24-hour double-probe pH monitoring of 222 children. Ann Otol Rhinol Laryngol Suppl 1997; 169: 1-16.
  • McMurray JS, Gerber M, Stern Y, et al. Role of laryngoscopy, dual pH probe monitoring, and laryngeal mucosal biopsy in the diagnosis of pharyngoesophageal reflux. Ann Otol Rhinol Laryngol 2001; 110: 299-304.
  • Ugras M, Ertem D, Cam S, Tutar E, Pehlivanoglu E. Can gastro- oesophageal reflux be predicted while advancing the endoscope through the laryngeal area? Gut 2005; 54: 890-891.
  • Aviv JE, Martin JH, Kim T, et al. Laryngopharyngeal sensory discrimination testing and the laryngeal adductor reflex.. Ann Otol Rhinol Laryngol 1999; 108: 725-730.
  • Rudolph CD, Mazur LJ, Liptak GS, et al.. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 2001; 32: 1-31.
  • Faure C, Michaud L, Shaghaghi EK, et al. Lansoprazole in children: pharmacokinetics and efficacy in reflux oesophagitis. Aliment Pharmacol Ther 2001; 15: 1397-1402.
  • Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. International Pediatric Omeprazole Study Group. J Pediatr 2000; 137: 800- 807.
  • Suskind DL, Zeringue GP 3rd, Kluka EA, Udall J, Liu DC.Gastroesophageal reflux and pediatric otolaryngologic disease: the role of antireflux surgery. Arch Otolaryngol Head Neck Surg 2001; 127: 511-514.
  • Hassall E. Decisions in diagnosing and managing chronic gastroesophageal reflux disease in children. J Pediatr 2005; 146: 3-12.
  • Kabul Tarihi: 11.03.2011
There are 27 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Meltem Uğraş This is me

Yaşar Doğan This is me

Publication Date February 1, 2011
Published in Issue Year 2011 Volume: 16 Issue: 1

Cite

APA Uğraş, M., & Doğan, Y. (2011). Çocukluk Çağında Laringofaringeal Reflü. Fırat Tıp Dergisi, 16(1), 1-5.
AMA Uğraş M, Doğan Y. Çocukluk Çağında Laringofaringeal Reflü. Fırat Tıp Dergisi. February 2011;16(1):1-5.
Chicago Uğraş, Meltem, and Yaşar Doğan. “Çocukluk Çağında Laringofaringeal Reflü”. Fırat Tıp Dergisi 16, no. 1 (February 2011): 1-5.
EndNote Uğraş M, Doğan Y (February 1, 2011) Çocukluk Çağında Laringofaringeal Reflü. Fırat Tıp Dergisi 16 1 1–5.
IEEE M. Uğraş and Y. Doğan, “Çocukluk Çağında Laringofaringeal Reflü”, Fırat Tıp Dergisi, vol. 16, no. 1, pp. 1–5, 2011.
ISNAD Uğraş, Meltem - Doğan, Yaşar. “Çocukluk Çağında Laringofaringeal Reflü”. Fırat Tıp Dergisi 16/1 (February 2011), 1-5.
JAMA Uğraş M, Doğan Y. Çocukluk Çağında Laringofaringeal Reflü. Fırat Tıp Dergisi. 2011;16:1–5.
MLA Uğraş, Meltem and Yaşar Doğan. “Çocukluk Çağında Laringofaringeal Reflü”. Fırat Tıp Dergisi, vol. 16, no. 1, 2011, pp. 1-5.
Vancouver Uğraş M, Doğan Y. Çocukluk Çağında Laringofaringeal Reflü. Fırat Tıp Dergisi. 2011;16(1):1-5.