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Follow Up of Serum Ca125 and CEA Levels For Treatment of Pulmonary Tuberculosis

Year 2006, Volume: 11 Issue: 2, 134 - 138, 01.04.2006

Abstract

Objectives: To determine the levels of Ca125 and CEA those are tumor markers at tuberculosis patients during the treatment. Materials and Methods: In 20 cases that were diagnosed as active pulmonary diagnosis (APT), the serum levels of CA-125 and CEA were measured initially and second and sixth months of the treatment. These results were compared with the results that obtained from 15 inactive pulmonary tuberculosis (IPT) cases and 15 healthy controls. Results: Serum CA-125 levels were higher at APT cases than in IPT cases and controls at the beginning of the treatment (p

References

  • World Health Organisation. The World Health Report 2000. Health systems: Improving performance. WHO, Geneva, 2000.
  • Hawken M, Nunn P, Gathua S, Brindle R, Godfrey-Faussett P, Githui W, Odhiambo J, Batchelor B, Gilks C, Morris J, et al. Increased recurrence of tuberculosis in HIV-1-infected patients in Kenya. Lancet. 1993; 342: 332-7.
  • Spence DP, Hotchkiss J, Williams CS, Davies PD. Tuberculosis and poverty. BMJ. 1993 Sep 25; 307: 759-61.
  • American Thoracic Society Documents. Treatment of Tuberculosis. Am J Respir Crit Care Med 2003; 167: 603–62.
  • Saltini C, Colizzi V. Soluble immunological markers of disease activity in tuberculosis. Eur Respir J 1999; 14: 485-6.
  • Simpkins F, Zahurak M, Armstrong D, Grumbine F, Bristow R. Ovarian malignancy in breast cancer patients with an adnexal mass. Obstet Gynecol 2005; 105: 507-13.
  • Canney PA, Moore M, Wilkinson PM, James RD. Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. Br J Cancer. 1984 Dec; 50: 765-9.
  • Berthiot G, Marechal F, Cattan A, Deltour G. Serum levels of CA-50, CA-19.9, CA-125, neuron specific enolase and carcinoembryonic antigen in lung cancer and benign diseases of the lung. Biomed Pharmacother 1989; 43: 613-20.
  • Buamah P. Benign conditions associated with raised serum CA- 125 concentration. J Surg Oncol 2000; 75: 264-5.
  • Sarobe P, Huarte E, Lasarte JJ, Borras-Cuesta F. Carcinoembryonic antigen as a target to induce anti-tumor immune responses. Curr Cancer Drug Targets 2004; 4: 443-54.
  • Ruibal Morell A. CEA serum levels in non-neoplastic disease. Int J Biol Markers 1992; 7: 160-6.
  • Yılmaz A, Ece F, Bayramgürler B, Akkaya E, Baran R. The value of Ca 125 in the evaluation of tuberculosis activity. Respir Med 2001; 95: 666-9.
  • Ichiki H, Shishido M, Nishitani K, Takatsugi K, Nishiyama S, Yano M, Watanabe K. Evaluation of CEA, SLX and CA125 in active pulmonary tuberculosis. Nihon Kyobu Shikkan Gakkai Zasshi 1993; 31: 1522-7.
  • Molina R, Filella X, Jo J, Agusti C, Ballesta AM. CA 125 in biological fluids. Int J Biol Markers 1998; 13: 224-30.
  • Diez M, Cerdan FJ, Ortega MD, Torres A, Picardo A, Balibrea JL. Evaluation of serum CA 125 as a tumor marker in non-small cell lung cancer. Cancer 1991; 67: 150-4.
  • Mas MR, Comert B, Saglamkaya U, Yamanel L, Kuzhan O, Ateskan U, Kocabalkan F. CA-125; a new marker for diagnosis and follow-up of patients with tuberculous peritonitis. Dig Liver Dis 2000; 32: 595-7.
  • Thakur V, Mukherjee U, Kumar K. Elevated serum cancer antigen 125 levels in advanced abdominal tuberculosis. Med Oncol 2001; 18: 289-91.
  • Uzunkoy A, Harma M, Harma M. Diagnosis of abdominal tuberculosis: experience from 11 cases and review of the literature. World J Gastroenterol 2004; 10: 3647-9.
  • Mansour M, Linden ER, Colby S, Posner G, Marsh F Jr. Elevation of carcinoembryonic antigen and CA-125 in a patient with multivisceral tuberculosis. J Natl Med Assoc 1997; 89: 142- 3.
  • Ferrer J, Villarino MA, Encabo G, Felip E, Bermejo B, Vila S, Orriols R. Diagnostic utility of CYFRA 21-1, carcinoembryonic antigen, CA 125, neuron specific enolase, and squamous cell antigen level determinations in the serum and pleural fluid of patients with pleural effusions. Cancer 1999; 86: 1488-95.
  • San Jose ME, Alvarez D, Valdes L, Sarandeses A, Valle JM, Penela P. Utility of tumour markers in the diagnosis of neoplastic pleural effusion. Clin Chim Acta 1997; 265: 193-205.
  • Matsuoka Y, Endo K, Kawamura Y, Yoshida T, Saga T, Watanabe Y, Koizumi M, Nakashima T, Konishi J, Yamaguchi N, et al. Normal bronchial mucus contains high levels of cancer- associated antigens, CA125, CA19-9, and carcinoembryonic antigen. Cancer 1990; 65: 506-10.
  • Hirose T, Ohta S, Sato I, Matsuda M, Arai T, Katsura T, Fukaura A, Nakajima H, Adachi M. Tuberculous pleuro-peritonitis showing increased levels of CA125. Nihon Kyobu Shikkan Gakkai Zasshi 1997; 35: 196-200.
  • Molina R, Filella X, Auge JM, Fuentes R, Bover I, Rifa J, Moreno V, Canals E, Vinolas N, Marquez A, Barreiro E, Borras J, Viladiu P. Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis. Comparison with the main clinical and pathological prognostic factors. Tumour Biol 2003; 24: 209-18.
  • Szklarz E, Gawlikowski W. Carcinoembryonic antigen (CEA) in the blood serum of patients with bronchogenic carcinoma and selected diseases of the respiratory tract. Pneumonol Pol. 1989 Apr; 57: 217-21.
  • Safianowska A, Grubek-Jaworska H, Droszcz P, Rybus L, Dabrowski A, Zwolska Z, Matysiak W, Chazan R. Levels of CEA, antibodies against mycobacterial antigens and ACE activity in serum and in BALF in patients with sarcoidosis, tuberculosis and lung cancer--preliminary results. Pneumonol Alergol Pol. 2001; 69: 5-13.
  • Garcia-Pachon E, Padilla-Navas I, Dosda MD, Miralles-Llopis A. Elevated level of carcinoembryonic antigen in nonmalignant pleural effusions. Chest 1997; 111: 643-7.
  • Riantawan P, Sangsayan P, Bangpattanasiri K, Rojanaraweewong P. Limited additive value of pleural fluid carcinoembryonic antigen level in malignant pleural effusion. Respiration 2000; 67: 24-9.
  • Ryu JS, Lee HJ, Cho JH, Han HS, Lee HL. The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion. Respirology 2003; 8: 487-91.
  • Kabul Tarihi: 08.02.2006

Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri

Year 2006, Volume: 11 Issue: 2, 134 - 138, 01.04.2006

Abstract

Amaç: Tümör belirleyicileri olan CA-125 ve CEA'nın tüberkülozlu hastalarda tedavi süresince serum düzeylerinin saptanması. Gereç ve Yöntem: Aktif akciğer tüberkülozu tanısı konulan 20 olguda, başlangıç ve tedavinin 2. ve 6. aylarında serum CA-125 ve CEA düzeyleri ölçüldü. Ayrıca elde edilen sonuçlar 15 inaktif tüberküloz olgusu ile 15 sağlıklı kontrol olgusundan elde edilen sonuçlarla karşılaştırıldı. Bulgular: Serum CA-125 düzeyleri aktif grupta tedavi başlangıcında hem inaktif hem de kontrol grubundan anlamlı olarak yüksekti (her iki grup için p

References

  • World Health Organisation. The World Health Report 2000. Health systems: Improving performance. WHO, Geneva, 2000.
  • Hawken M, Nunn P, Gathua S, Brindle R, Godfrey-Faussett P, Githui W, Odhiambo J, Batchelor B, Gilks C, Morris J, et al. Increased recurrence of tuberculosis in HIV-1-infected patients in Kenya. Lancet. 1993; 342: 332-7.
  • Spence DP, Hotchkiss J, Williams CS, Davies PD. Tuberculosis and poverty. BMJ. 1993 Sep 25; 307: 759-61.
  • American Thoracic Society Documents. Treatment of Tuberculosis. Am J Respir Crit Care Med 2003; 167: 603–62.
  • Saltini C, Colizzi V. Soluble immunological markers of disease activity in tuberculosis. Eur Respir J 1999; 14: 485-6.
  • Simpkins F, Zahurak M, Armstrong D, Grumbine F, Bristow R. Ovarian malignancy in breast cancer patients with an adnexal mass. Obstet Gynecol 2005; 105: 507-13.
  • Canney PA, Moore M, Wilkinson PM, James RD. Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. Br J Cancer. 1984 Dec; 50: 765-9.
  • Berthiot G, Marechal F, Cattan A, Deltour G. Serum levels of CA-50, CA-19.9, CA-125, neuron specific enolase and carcinoembryonic antigen in lung cancer and benign diseases of the lung. Biomed Pharmacother 1989; 43: 613-20.
  • Buamah P. Benign conditions associated with raised serum CA- 125 concentration. J Surg Oncol 2000; 75: 264-5.
  • Sarobe P, Huarte E, Lasarte JJ, Borras-Cuesta F. Carcinoembryonic antigen as a target to induce anti-tumor immune responses. Curr Cancer Drug Targets 2004; 4: 443-54.
  • Ruibal Morell A. CEA serum levels in non-neoplastic disease. Int J Biol Markers 1992; 7: 160-6.
  • Yılmaz A, Ece F, Bayramgürler B, Akkaya E, Baran R. The value of Ca 125 in the evaluation of tuberculosis activity. Respir Med 2001; 95: 666-9.
  • Ichiki H, Shishido M, Nishitani K, Takatsugi K, Nishiyama S, Yano M, Watanabe K. Evaluation of CEA, SLX and CA125 in active pulmonary tuberculosis. Nihon Kyobu Shikkan Gakkai Zasshi 1993; 31: 1522-7.
  • Molina R, Filella X, Jo J, Agusti C, Ballesta AM. CA 125 in biological fluids. Int J Biol Markers 1998; 13: 224-30.
  • Diez M, Cerdan FJ, Ortega MD, Torres A, Picardo A, Balibrea JL. Evaluation of serum CA 125 as a tumor marker in non-small cell lung cancer. Cancer 1991; 67: 150-4.
  • Mas MR, Comert B, Saglamkaya U, Yamanel L, Kuzhan O, Ateskan U, Kocabalkan F. CA-125; a new marker for diagnosis and follow-up of patients with tuberculous peritonitis. Dig Liver Dis 2000; 32: 595-7.
  • Thakur V, Mukherjee U, Kumar K. Elevated serum cancer antigen 125 levels in advanced abdominal tuberculosis. Med Oncol 2001; 18: 289-91.
  • Uzunkoy A, Harma M, Harma M. Diagnosis of abdominal tuberculosis: experience from 11 cases and review of the literature. World J Gastroenterol 2004; 10: 3647-9.
  • Mansour M, Linden ER, Colby S, Posner G, Marsh F Jr. Elevation of carcinoembryonic antigen and CA-125 in a patient with multivisceral tuberculosis. J Natl Med Assoc 1997; 89: 142- 3.
  • Ferrer J, Villarino MA, Encabo G, Felip E, Bermejo B, Vila S, Orriols R. Diagnostic utility of CYFRA 21-1, carcinoembryonic antigen, CA 125, neuron specific enolase, and squamous cell antigen level determinations in the serum and pleural fluid of patients with pleural effusions. Cancer 1999; 86: 1488-95.
  • San Jose ME, Alvarez D, Valdes L, Sarandeses A, Valle JM, Penela P. Utility of tumour markers in the diagnosis of neoplastic pleural effusion. Clin Chim Acta 1997; 265: 193-205.
  • Matsuoka Y, Endo K, Kawamura Y, Yoshida T, Saga T, Watanabe Y, Koizumi M, Nakashima T, Konishi J, Yamaguchi N, et al. Normal bronchial mucus contains high levels of cancer- associated antigens, CA125, CA19-9, and carcinoembryonic antigen. Cancer 1990; 65: 506-10.
  • Hirose T, Ohta S, Sato I, Matsuda M, Arai T, Katsura T, Fukaura A, Nakajima H, Adachi M. Tuberculous pleuro-peritonitis showing increased levels of CA125. Nihon Kyobu Shikkan Gakkai Zasshi 1997; 35: 196-200.
  • Molina R, Filella X, Auge JM, Fuentes R, Bover I, Rifa J, Moreno V, Canals E, Vinolas N, Marquez A, Barreiro E, Borras J, Viladiu P. Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis. Comparison with the main clinical and pathological prognostic factors. Tumour Biol 2003; 24: 209-18.
  • Szklarz E, Gawlikowski W. Carcinoembryonic antigen (CEA) in the blood serum of patients with bronchogenic carcinoma and selected diseases of the respiratory tract. Pneumonol Pol. 1989 Apr; 57: 217-21.
  • Safianowska A, Grubek-Jaworska H, Droszcz P, Rybus L, Dabrowski A, Zwolska Z, Matysiak W, Chazan R. Levels of CEA, antibodies against mycobacterial antigens and ACE activity in serum and in BALF in patients with sarcoidosis, tuberculosis and lung cancer--preliminary results. Pneumonol Alergol Pol. 2001; 69: 5-13.
  • Garcia-Pachon E, Padilla-Navas I, Dosda MD, Miralles-Llopis A. Elevated level of carcinoembryonic antigen in nonmalignant pleural effusions. Chest 1997; 111: 643-7.
  • Riantawan P, Sangsayan P, Bangpattanasiri K, Rojanaraweewong P. Limited additive value of pleural fluid carcinoembryonic antigen level in malignant pleural effusion. Respiration 2000; 67: 24-9.
  • Ryu JS, Lee HJ, Cho JH, Han HS, Lee HL. The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion. Respirology 2003; 8: 487-91.
  • Kabul Tarihi: 08.02.2006
There are 30 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Teyfik Turgut This is me

Figen Deveci This is me

Necip İlhan This is me

Canan Kaçar This is me

Mehmet Hamdi Muz This is me

Publication Date April 1, 2006
Published in Issue Year 2006 Volume: 11 Issue: 2

Cite

APA Turgut, T., Deveci, F., İlhan, N., Kaçar, C., et al. (2006). Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri. Fırat Tıp Dergisi, 11(2), 134-138.
AMA Turgut T, Deveci F, İlhan N, Kaçar C, Muz MH. Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri. Fırat Tıp Dergisi. April 2006;11(2):134-138.
Chicago Turgut, Teyfik, Figen Deveci, Necip İlhan, Canan Kaçar, and Mehmet Hamdi Muz. “Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 Ve CEA Düzeyleri”. Fırat Tıp Dergisi 11, no. 2 (April 2006): 134-38.
EndNote Turgut T, Deveci F, İlhan N, Kaçar C, Muz MH (April 1, 2006) Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri. Fırat Tıp Dergisi 11 2 134–138.
IEEE T. Turgut, F. Deveci, N. İlhan, C. Kaçar, and M. H. Muz, “Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri”, Fırat Tıp Dergisi, vol. 11, no. 2, pp. 134–138, 2006.
ISNAD Turgut, Teyfik et al. “Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 Ve CEA Düzeyleri”. Fırat Tıp Dergisi 11/2 (April 2006), 134-138.
JAMA Turgut T, Deveci F, İlhan N, Kaçar C, Muz MH. Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri. Fırat Tıp Dergisi. 2006;11:134–138.
MLA Turgut, Teyfik et al. “Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 Ve CEA Düzeyleri”. Fırat Tıp Dergisi, vol. 11, no. 2, 2006, pp. 134-8.
Vancouver Turgut T, Deveci F, İlhan N, Kaçar C, Muz MH. Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri. Fırat Tıp Dergisi. 2006;11(2):134-8.