Medicinal values of a Saiva ritual plant-Bauhinia tomentosa L.

Year 2020, Volume: 1 Issue: 2, 63 - 68, 30.12.2020

Saravanan Vivekanandarajah Sathasivampillai , Pholtan Rajeev Sebastian , Sujarajini Varatharasan

Abstract

Bauhinia tomentosa L. is a small tree that belongs to the Fabaceae family and it is distributed in Asia, Africa, North America, and Oceania. ‎B. tomentosa is used to treat some diseases including liver inflammation, abscess, tumors, wounds, and hyperlipidemia in ethnomedicines in Asia and Africa. Compounds like phytone, β-cubebene, β-caryophyllene, 3-O-methyl-d-glucose, and phthalic acid have been isolated from leaves of this plant species. This review article aims to analyze, document, and summarize the reported bioactivities of this plant species. A literature review was conducted using electronic databases like the Web of Science, Scopus, PubMed, and Science Direct to identify the relevant published studies from the year 1900 to November 2020. Various parts of B. tomentosa exhibited bioactivities such as analgesic, anti-anxiety, antibacterial, anticatatonic, anticonvulsant, antidepressant, antidiabetic, antifungal, anthelminthic, antihyperlipidemic, antinociceptive, antioxidant, antipyretic, anti-ulcerative colitis, motor coordination, nephroprotective, nootropic, and wound healing activities in various assays and animal models. However, no bioactive compound has been isolated from this plant species. It was observed that a daily dose of 3000 mg/kg was safe in animal models. Hence, further phytochemical and bioactivity studies should be conducted to explore more about this plant species. This work analyzed, documented, and summarized the reported bioactivities of B. tomentosa that will be very useful for further phytochemical and bioactivities related researches.

Keywords

Bauhinia tomentosa, bioactivity, cancer, Fabaceae, microbiota, Sri Lanka

Supporting Institution

Not applicable

Project Number

Not applicable

Thanks

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References

• Aditya, P., Pandurang, K., Atul, D., Gajanan Kotlgaonkar, R., Prashant, P., Pravin, H., Prasad, J. (2013). Comparative evaluation of in-vitro antihelminthic activity of Bauhinia tomentosa. International Journal of Drug Development and Research, 5(2), 109-114.
• Banerjee, A., & De, B. (2014). Antioxidant activity of ethnomedicinally used flowers of West Bengal, India. International Journal of Phar-macognosy and Phytochemical Research, 6(3), 622-635.
• Chopra, R. N., Asolkar, L. V., Nayar, S. L., Kakkar, K. K., Chakre, O. J., & Chopra, I. C. (1992). Glossary of Indian medicinal plants. (pp. 1-329). New Delhi: Publications & Information Directorate.
• Devaki, K., Beulah, U., Akila, G., Sunitha, M., Narmadha, R., & Go-plakrishnan, V. K. (2011). Effect of aqueous leaf extract of B.tomentosa on GTT of normal and diabetic rats. Pharmacologyonline, 3, 195-202.
• Dugasani, S., Balijepalli, M., Tandra, S., & Pichika, M. (2010). Antimi-crobial activity of Bauhinia tomentosa and Bauhinia vahlii roots. Pharmacognosy Magazine, 6(23), 204-207. https://doi.org/10.4103/0973-1296. 66937
• Kannan, N., & Guruvayoorappan, C. (2013). Protective effect of Bau-hinia tomentosa on acetic acid induced ulcerative colitis by regulat-ing antioxidant and inflammatory mediators. International Im-munopharmaco-logy, 16(1), 57-66. https://doi.org/10.1016/j.intimp.2013.03.008
• Kannan, N., Renitta, R. E., & Guruvayoorappan, C. (2010). Bauhinia tomentosa stimulates the immune system and scavenges free radical ge-neration in vitro. Journal of Basic and Clinical Physiology and Pharmacology, 21(2), 157-168. https://doi.org/10.1515/JBCPP.2010.21.2. 157
• Kannan, N., Sakthivel, K. M., & Guruvayoorappan, C. (2016). Nephro-protective effect of Bauhinia tomentosa Linn against cisplatin-induced renal damage. Journal of Environmental Pathology, Toxi-cology and Oncology, 35(2), 99-107. https://doi.org/10.1615/JEnvironPatholToxicolOncol.2016013981
• Kaur, A. K., Jain, S. K., Gupta, A., Gupta, S. K., Bansal, M., & Sharma, P. K. (2011). Antidiabetic activity of Bauhinia tomentosa Linn. Roots extract in alloxan induced diabetic rats. Der Pharmacia Lettre, 3(2), 456-459.
• Kirtikar, K., & Basu, B. D. (2005). Indian medicinal plants. vol. 1., (pp. 1-430). Dehradun: International Book Distributors.
• Krishnaswamy, T., Sellamuthu, M., & Subramaniam, P. (2013). In vitro radical scavenging potential of pod and seed extracts of Bauhinia tomentosa L. International Journal of Pharmacy and Pharmaceuti-cal Sciences, 5(1), 346-351.
• Mannangatti, V., Ayyasamy, B., Rangasamy, M., Emin, B., & Natesan, S. K. (2010a). Anti-hyperglycemic and anti-lipidemic activity of ethanolic extract of Bauhinia tomentosa (Linn) flower in normal and streptozotocin-induced diabetic rats. Journal of Global Pharma Technology, 2(3), 71-76.
• Mannangatti, V., Ayyasamy, B., Rangasamy, M., & Kumar, N. S. (2010b). Antioxidant potential of ethanolic extract of Bauhinia to-mentosa (Linn) flower. Research Journal of Pharmaceutical Biolog-ical and Chemical Sciences, 1(2), 143-147.
• Mythreyi, R., Murugan, M., Muthusamy, P., & Venkatesh, S. (2005). Antimicrobial activity of the leaves of Bauhinia tomentosa Linn. In-dian Journal of Pharmaceutical Sciences, 67(6), 732-736.
• Orwa, C., Mutua, A., Kindt, R., Jamnadass, R., & Simons, A. (2009). Bauhinia tomentosa L. Agrofostree Species profile website: http://apps.worldagroforestry.org/treedb2/speciesprofile.php?Spid=17 39, Last accessed on November 12, 2020.
• Panda, P., Sahu, S., Pal, A., Biswasroy, P., Kar, D. M., & Ghosh, G. (2018). Evaluation of wound healing activity of three different spe-cies of Bauhinia on experimental animal models. Journal of Global Pharma Technology, 10(12), 13-18.
• Panda, P., Sharma, T., Pal, A., & Ghosh, G. (2019). GC-MS profiling and in vitro tyrosinase inhibitory activities of Bauhinia racemosa Lamk. and Bauhinia tomentosa Linn. Iranian Journal of Science and Technology, Transaction A: Science, 43(4), 1417-1426. https://doi.org/10. 1007/s40995-018-0635-4
• Risa, J., Risa, A., Adsersen, A., Gauguin, B., Stafford, G. I., Van Staden, J., & Jäger, A. K. (2004). Screening of plants used in south-ern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay. Journal of Ethnopharmacology, 93(2-3), 177-182. https://doi.org/10.1016/j.jep.2004.01.021
• Royal Botanic Gardens, Kew. (2020). Bauhinia tomentosa L. Plants of the World Online Kew Science. Plants of the World Online website: http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30193-2, Last accessed on November 9, 2020.
• Sastri, B. N. (1995). The wealth of India. a dictionary of Indian raw materials and industrial products. Raw materials. vol. 6: LM. (pp. 1-483). New Delhi: Publications & Information Directorate.
• Sathya, B., Ariharasivakumar, G., Vimalson, D. C., Subramani, M., & Magesh, M. (2011). Psychopharmacological evaluation of ethanolic extract of leaves of Bauhinia tomentosa L. in mice. International Journal of Pharmacy and Technology, 3(4), 3693-3709.
• Tiwari, V., & Singh, A. (2013). Elucidation of possible mechanism of anti-nociceptive and anti-oxidant potential of Bauhinia tomentosa extracts in experimental animal models. Natural Products Journal, 3(4), 309-316. https://doi.org/10.2174/221031550304140328114559
• Tiwari, V., & Singh, A. (2014). Evaluation of anti-hyperglycemic po-tential of Bauhinia tomentosa standardized extracts in streptozoto-cin-induced diabetic rats. Iranian Journal of Pharmaceutical Sci-ences, 10(1), 1-14.
• Tiwari, V., & Singh, A. (2015). Comparative analysis of Bauhinia tomentosa L. and Kalanchoe pinnata Lam extracts with regard to their antinociceptive and antipyretic potentials in experimental ani-mal models. International Journal of Green Pharmacy, 9(1), 32-38. https://doi.org/10.4103/0973-8258.150920
• Vasudevan, V., Mathew, J., & Baby, S. (2014). Chemical profiles of essential oils of Bauhinia species from South India. Asian Journal of Che-mistry, 26(8), 2204-2206. https://doi.org/10.14233/ajchem.2014.15654