Evaluation of the relation of Platelet Volume Index, MPV and RDW values with mortality in spontaneous intraparenchymal hemorrhages

Year 2021, Volume: 6 Issue: 1, 35 - 42, 03.04.2021

Dilek Atik Basar Cander Ramiz Yazıcı Bensu Bulut Ramazan Ünal Eren Sert

https://doi.org/10.22391/fppc.817258

Abstract

Introduction: Intracerebral Spontaneous Hemorrhage (ISH) is a sudden hemorrhage into the brain parenchyma as a result of a rupture of the cerebral vessels that are not related to traumas. The purpose of the present study was to evaluate the relation of mortality with Platelet Volume Index (PVI) scoring systems, which have been reported in a small number of studies in terms of blood RDW, MPV, platelet and intracranial hemorrhages in patients diagnosed with intraparenchymal hemorrhage in Emergency Departments.
Methods: This study was performed retrospectively by examining patient files of patients who came to Emergency Medicine Clinic between 01.01.2019-31.12.2019. As a control group for comparison of blood parameters, blood parameters of 72 patients suitable for the same age population, without intraparenchymal haemorrhage.
Results: A total of 54.10% (n=85) intraparenchymal bleeding patients (IPC) and 45.90% (n=72) healthy control groups (HCG) were included in the study. There was no statistically significant difference between the clinical results of IPC groups in terms of mortality of RDW parameter and MPV parameter (p=0.930; p=0.118). When PVI ratio was evaluated in IPC group and HCG; the mean PVI (MPV/Platelet ratio) in the IPC group was 4.37±1.66, and the PVI (MPV/Platelet ratio) in the HCG was 3.89±1.02.A statistically significant difference was found between the PVI in the patient group and the HCG.A statistically significant difference was found between the PVI ratio clinical results of the patients with IPC (p=0.043).
Conclusion: Spontaneous Intraparenchymal hemorrhage are among the leading causes of stroke-induced mortality and disability. The Hemphill Score and hemorrhage volume are important factors in mortality evaluation in intraparenchymal hemorrhage. There are not many studied conducted on Platelet Volume Index, and it is an important marker in predicting mortality, especially in these patients. 

Keywords

Intraparenchymal haemorrhage, Mean platelet volume, Red cell distribution width

Spontan intraparankimal kanamalarda Platelet Volüm İndex, MPV ve RDW değerlerinin mortalite ile ilişkisinin değerlendirilmesi

Abstract

Giriş: Spontan İntraserebral hemoraji (İSH), aniden oluşan ,travmaya bağlı olmayan beyin damarları rüptürü sonucu beyin parankimi içine kanamalardır. Bu çalışma ile intraparankimal kanama tanısı alan hastalarında kan RDW, MPV, platelet ve şu ana kadar intrakraniyal hemorajilerde az sayıda çalışma bildirilen platelet volüm indexinin (PVI) skorlama sistemleri ile birlikte mortalite ilişkisini değerlendirmesini amaçladık.
Yöntem: Bu çalışma 01.01.2019-31.12.2019 tarihleri arasında Acil Tıp Kliniğine gelen hastaların hasta dosyaları incelenerek retrospektif olarak yapıldı. Kan parametrelerinin karşılaştırılması için kontrol grubu olarak, intraparankimal kanama olmayan aynı yaş popülasyonuna uygun 72 hastanın kan parametreleri değerlendirildi. Klinik sonuçlara göre RDW, MPV, Platelet ve PVI kan parametreleri değerlendirildi.
Bulgular: Çalışmaya toplam %54,10 (n = 85) intraparankimal kanama hastası (IPK) ve %45,90 (n = 72) sağlıklı kontrol grubu (SKG) dahil edildi. IPK gruplarının klinik sonuçları arasında RDW parametresi ve MPV parametresinin mortalitesi açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,930;p=0,118). IPK grubu ve SKG'de PVI oranı değerlendirildiğinde; ortalama PVI (MPV/Trombosit oranı) IPK grubu 4,37± 1,66 ve SKG'deki PVI (MPV/Trombosit oranı) 3,89 ± 1,02 idi. Hasta grubundaki PVI oranı ile SKG arasında istatistiksel olarak anlamlı bir fark bulundu. IPC'li hastaların PVI oranı klinik sonuçları değerlendirildi; mortalite açısından gruplar arasında istatistiksel olarak anlamlı fark vardı (p=0,043).
Sonuç: Spontan intraparankimal kanama, inmeye bağlı mortalite ve özürlülüğün önde gelen nedenleri arasındadır. Hemphill Score ve kanama hacmi intraparankimal kanamada mortalite değerlendirmesinde önemli faktörlerdir. Platelet Hacim İndeksi üzerine yapılmış çok fazla çalışma yoktur ve özellikle bu hastalarda mortaliteyi öngörmede önemli bir belirteçtir.

Keywords

İntraparankimal kanama, Ortalama trombosit hacmi, Kırmızı hücre dağılım genişliği

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