Clinical and laboratory differences between healthy and COVID-19 positive pregnant women and the negative effects of COVID-19 on pregnancy

Year 2023, Volume: 8 Issue: 3, 58 - 64, 29.05.2023

Kazım Kıratlı Didem Kıratlı Mustafa Şengül

https://doi.org/10.22391/fppc.1227192

Abstract

Introduction: Depending on pregnancy; physiological changes in the immune system, respiratory and circulatory systems may cause a more severe course of infection with respiratory viruses. The aim of this study is to examine the clinical and laboratory findings of our pregnant patients with and without COVID-19 and to determine whether COVID-19 disease has a negative effect on late pregnancy.
Methods: This study was conducted with a total of 60 pregnant patients followed in the Infectious Diseases and Clinical Microbiology Clinic and Gynecology and Obstetrics Clinic of a Training and Research Hospital. Demographic characteristics and laboratory findings of pregnant women and their fetuses were obtained from the hospital management information system.
Results: The mean age of the COVID-19 positive pregnant women (n:30) included in the study was 28.87±1.38 years, the mean hospitalization time was 6.33±0.35 days, and it was significantly different from the COVID-19 negative group (n:30) (p<0.001). The most common symptom observed in COVID-19 positive pregnant women at presentation was fever (73.3%), followed by cough (53.3%) and headache (43.3%). C-reactive protein (25.53±5.79, p: 0.005), ferritin (83.97±10.51, p: 0.005) and erythrocyte sedimentation rate (30.97± 4.59, p: 0.011) were found to be higher in COVID-19 positive pregnant women.
Conclusion: In conclusion; CRP, ferritin and ESR levels were found to be higher in pregnant women with COVID-19. It is important for healthcare providers to know the clinical course of COVID-19, maternofetal or obstetric outcomes in the pregnant population. Mode and timing of delivery should be individualized according to disease severity, pre-existing maternal comorbidities, obstetric history, gestational age, and fetal conditions.
Keywords: COVID-19, C-reactive protein, cough, pregnancy

Keywords

COVID-19, C-reactive protein, cough, pregnancy

Sağlıklı ve COVID-19 pozitif gebeler arasındaki klinik ve laboratuvar farklılıklar ve COVID-19’un gebelik üzerine olumsuz etkileri

Abstract

Giriş: Hamileliğe bağlı olarak; bağışıklık sistemi, solunum ve dolaşım sistemlerindeki fizyolojik değişiklikler solunum yolu virüsleri ile daha ciddi bir enfeksiyon seyrine neden olabilir. Bu araştırmanın amacı, COVID-19 olan ve olmayan gebe hastalarımızın klinik ve laboratuvar bulgularını incelemek ve COVID-19 hastalığının geç gebelik üzerinde olumsuz bir etkisi olup olmadığını belirlemektir.
Yöntem: Bu çalışma, bir Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği ile Kadın Hastalıkları ve Doğum Kliniğinde takip edilen toplam 60 gebe hasta ile yapılmıştır. Gebelerin ve fetüslerin demografik özellikleri ve laboratuvar bulguları hastane yönetim bilgi sisteminden elde edildi.
Bulgular: Çalışmaya alınan COVID-19 pozitif gebelerin (n:30) ortalama yaşı 28,87±1,38 yıl, ortalama hastanede kalış süresi 6,33±0,35 gün olup, COVID-19 negatif gruptan (n:30) anlamlı olarak farklıydı (p<0,001). COVID-19 pozitif gebelerde başvuru anında en sık görülen semptom ateş oldu (%73,3), bunu öksürük (%53,3) ve baş ağrısı (%43,3) izledi. COVID-19 pozitif gebelerde C-reaktif protein (25,53±5,79, p:0,005), ferritin (83,97±10,51, p:0,005) ve eritrosit sedimantasyon hızı (30,97±4,59, p:0,011) daha yüksek bulundu.
Sonuç: CRP, ferritin ve ESR düzeyleri COVID-19'lu gebelerde daha yüksek bulundu. Sağlık hizmeti sunucularının hamile popülasyonda COVID-19'un klinik seyrini, anne karnındaki veya doğumla ilgili sonuçları bilmesi önemlidir. Doğum şekli ve zamanlaması, hastalığın ciddiyetine, önceden var olan maternal komorbiditelere, obstetrik öyküye, gebelik yaşına ve fetal koşullara göre kişiselleştirilmelidir.
Anahtar Kelimeler: COVID-19, C-reaktif protein, öksürük, gebelik

Keywords

COVID-19, C-reaktif protein, öksürük, gebelik

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