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Sık akraba evliliği yapılan bir bölgede büyük bir ekokardiyografi serisinde bikuspit aortik kapak prevalansı

Year 2009, Volume: 15 Issue: 2, 15 - 18, 01.03.2009

Murat Sucu Vedat Davutoğlu Orhan Özer Osman Başpınar Mehmet Aksoy Metin Kılıç

Abstract

Bicuspid aortic valve (BAV) is one of the most common congenital anomalies of the heart, though its definitive prevalence is not dear. We sought to determine the prevalence of BAV in a large database of echocardiographic measurements from a single institution in the area of frequent consanguineous marriage (South-east Anatolia region) and we present the frequencies of BAV-related complications such as stenosis, regurgitation, and assendan aorta dilatation. We retrospectively analyzed 31.265 echocardiograms performed at our academic institution between 2004 and 2007 for various indications. BAV is often associated with aortic stenosis, regurgitation, and ascending aorta dilatation and BAV is an independent risk factor for infective endocarditis. The prevalence of BAV was calculated, and the frequency of aortic stenosis, regurgitation, and ascending aorta dilatation among BAV cases was determined. Our database revealed a gender distribution of 11.339 males (47%) and 12.926 (53%) females.The total prevalence of BAV was 0.57% (n = 180). The rate of consanguineous marriage is 20.9% in overeall Turkey. The rate of consanguineous marriage is 40.4% in our region The gender-specific prevalence was 1.08% in males and 0.44% in females. Regurgitation was observed in 58.3% (28.9% mild, 29.4% severe) of BAV cases, stenosis in 40% (17.8% mild, 22.2% severe), and dilatation in 33.3%. The prevalence determined in our study is similar to the prevalence determined in other,recent echocardiography and autopsy studies, suggesting a lower incidence of BAV than previously thought despite high rate of consanguineous marriage. Regurgitation was the most common valvular complication in our database.

Keywords

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References

  • l.Braverman AC, Guven H, Beardslee MA, Makan M, Kates AM, Moon MR. The bicuspid aortic valve. Curr Probl Cardiol. 2005;30:470-522
  • 2.Yener N, Oktar GL, Erer D, Yardimci MM, Yener A. Bicuspid aortic valve. Ann Thorac Cardiovasc Surg. 2002;8:264-267
  • 3.Fenoglio JJ Jr, McAllister HA Jr, DeCastro CM, Davia JE, Cheitlin MD. Congenital bicuspid aortic valve after age 20. Am J Cardiol. 1977;39:164-169
  • 4.Roberts WC, Morrow AG, Mclntosh CL, Jones M, Epstein SE. Congenially bicuspid aortic valve causing severe, pure aortic regurgitation without superimposed infective endocarditis. Analysis of 13 patients requiring aortic valve replacement. Am 3 Cardiol. 1981;47:206-209
  • 5.Dore A, Brochu MC, Baril JF, Guertin MC, Mercier LA. Progressive dilation of the diameter of the aortic root in adults with a bicuspid aortic valve. Cardiol Young. 2003;13:526-531
  • 6.Lamas CC, Eykyn SJ. Bicuspid aortic valve-A silent danger: analysis of 50 cases of infective endocarditis. Clin Infect Dis. 2000;30:336-341
  • 7.Basso C, Boschello M, Perrone C, Mecenero A, Cera A, Bicego D, et al. An echocardiographic survey of primary school children for bicuspid aortic valve. Am J Cardiol. 2004;93:661-663
  • 8.Datta BN, Bhusnurmath B, Khattri HN, Sapru RP, Bidwai PS, Wahi PL. Anatomically isolated aortic valve disease. Morphologic study of 100 cases at autopsy. Jpn Heart J. 1988;29:661-670
  • 9.Gross L. So-called congenital bicuspid aortic valve. Arch Pathol. 1937;23:350-362
  • lO.Pauperip HM, Azevedo AC, Ferreira CS. The aortic valve with two leaflets-a study in 2,000 autopsies. Cardiol Young. 1999;9:488-498
  • ll.Wauchope GM. The clinical importance of variations in the number of cusps forming the aortic and pulmonary valves. Quart J Med. 1928;21:383-399
  • 12.Larson EW, Edwards WD. Risk factors for aortic dissection: a necropsy study of 161 cases. Am J Cardiol. 1984; 53:849-855
  • 13.Roberts WC. The congenially bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol. 1970;26:72-83
  • 14.Anabwani GM, Bonhoeffer P. Prevalence of heart disease in school children in rural Kenya using colour-flow echocardiography. East Afr Med J. 1996;73:215-217
  • 15.Gupta I, Gupta ML, Parihar A, Gupta CD.Epidemiology of rheumatic and congenital heart diseases in school children. J Indian Med Assoc. 1992;90:57-59
  • 16.Stephensen SS, Sigfüsson G, Eirîksson H, Sverrisson JT, Torfason B, Haraldsson A,et al. Congenital cardiac malformations in Iceland from 1990 through 1999. Cardiol Young. 2004; 14:396-401
  • 17.Steinberger J, Moller JH, Berry JM, Sinaiko AR. Echocardiographic diagnosis of heart disease in apparently healthy adolescents. Pediatrics. 2000;1054:815-818
  • 18.Tutar E, Ekici F, Atalay S, Nacar N. The prevalence of bicuspid aortic valve in newborns by echocardiographic screening. Am Heart J. 2005;150:513-515
  • 19.Movahed MR, Hepner AD, Ahmadi-Kashani M. Echocardiographic prevalence of bicuspid aortic valve in the population. Heart Lung Circ. 2006;15:297-299
  • 2O.Alegret JM, Palomares R, Duran I, Vernis JM, Palazon O. Effect of age on valvular dysfunction and aortic dilatation in patients with a bicuspid aortic valve. Rev Esp Cardiol. 2006;59:503-506
  • 21. Hahn RT, Roman MJ, Mogtader AH, Devereux RB. Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves. J Am Coll Cardiol 1992;19:283-288
  • 22.Pachulski RT, Chan KL. Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography. Br Heart J. 1993;69:237-240
  • 23.Sabet HY, Edwards WD, Tazelaar HD, Daly RC. Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2715 additional cases. Mayo Clin Proc. 1999;74:14-26
  • 24.Bauer M, Pasic M, Schaffarzyk R, Siniawski H, Knollmann F, Meyer R, et al. Reduction aortoplasty for dilatation of the ascending aorta in patients with bicuspid aortic valve. Ann Thorac Surg. 2002;73:720-724
  • 25.Cecconi M, Nistri S, Quarti A, Manfrin M, Colonna PL, Molini E, et al. Aortic dilatation in patients with bicuspid aortic valve. J Cardiovasc Med (Hagerstown). 2006;7:ll-20
  • 26.Cripe L, Andelfinger G, Martin U, Shooner K, Benson DW. Bicuspid aortic valve is heritable. J Am Coll Cardiol. 2004;44:138-143
  • 27.Atalay S, Özme Ş, Özkutlu S, Özer Ş, Balcı S. Recurrence risks of congenital heart disease. Türkiye Klinikleri J Pediatr. 1993;4:188-91
  • 28.Güler N, Özkara C. Aortic Regurgitation. Türkiye Klinikleri J Int Med Sci. 2006;15:35-38

Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı

Year 2009, Volume: 15 Issue: 2, 15 - 18, 01.03.2009

Murat Sucu Vedat Davutoğlu Orhan Özer Osman Başpınar Mehmet Aksoy Metin Kılıç

Abstract

Bikuspit aort kapak (BAK) kalbin en sık korijenitai anomalilerinden olmakla beraber prevalansı tam olarak belli değildir. Akraba evliliğinin yaygın olduğu (Güneydoğu Anadolu Bölgesi) bir bölgeden tek merkeze ait, büyük bir ekokardiyografik veri tabanından,' BAK'ın'prevalansını tespit etmeyi amaçladık ve BAK ile ilişkili aort stenozu, yetersizliği ve çıkan aorta dilatasyonu gibi komlikasyonlarıri sıklığını sunduk. Üniversite hastanemizde 2004 ye 2007 yıllan arasında çeşitli endikasyonlar için yapılan ve ekokardiyografik veri tabanında'kayıtlı bulunan 31.265 raporu retrospektif olarak inceledik. BAK sıklıkla aort stenozu, yetersizliği ve çıkan aortanın genişlemesi ile birliktedir. BAK infektif endokardit için bağımsız bir risk faktörüdür. BAK'un prevelansı hesaplandı ve BAK olanlarda aort darlığı, aort yetersizliği ve çıkan aortanın genişleme sıklığı araştırıldı. Veri tabanımız cinsiyet dağılımını 11.939 erkek (%47) 12.926 kadın(%53) olarak'göstermiştir BAK prevalansı %0.57'ydi (n: 180). Tüm Türkiye de akraba evliliği oranı %20.9 dur. Bölgemizde akraba evliliği oranı %40.4. Cinsiyete özgü BAK prevalansı erkeklerde %1.08, kadınlarda %0.44'tü. BAK'lıların % 58.3'ünde aort yetersizliği (%28.9. hafif, %29.4 ileri), %40;ında aort darlığı (%17.8 hafif, %22.2 şiddetli) ve %33.3'ünde çıkan aortta genişleme gözlemlendi. Yüksek akraba evliliği oranına rağmen çalışmamızda BAK prevelansı daha önce yapılan ekokardiyografi ve otopsi çalışmaları ile benzer ve tahmin , edilenden az bulundu. Veri tabanımıza göre aort yetersizliği eri sık eşlik eden komplikasyondu.

Keywords

Ekokardiografi Biküspit Aort Kapak

References

  • l.Braverman AC, Guven H, Beardslee MA, Makan M, Kates AM, Moon MR. The bicuspid aortic valve. Curr Probl Cardiol. 2005;30:470-522
  • 2.Yener N, Oktar GL, Erer D, Yardimci MM, Yener A. Bicuspid aortic valve. Ann Thorac Cardiovasc Surg. 2002;8:264-267
  • 3.Fenoglio JJ Jr, McAllister HA Jr, DeCastro CM, Davia JE, Cheitlin MD. Congenital bicuspid aortic valve after age 20. Am J Cardiol. 1977;39:164-169
  • 4.Roberts WC, Morrow AG, Mclntosh CL, Jones M, Epstein SE. Congenially bicuspid aortic valve causing severe, pure aortic regurgitation without superimposed infective endocarditis. Analysis of 13 patients requiring aortic valve replacement. Am 3 Cardiol. 1981;47:206-209
  • 5.Dore A, Brochu MC, Baril JF, Guertin MC, Mercier LA. Progressive dilation of the diameter of the aortic root in adults with a bicuspid aortic valve. Cardiol Young. 2003;13:526-531
  • 6.Lamas CC, Eykyn SJ. Bicuspid aortic valve-A silent danger: analysis of 50 cases of infective endocarditis. Clin Infect Dis. 2000;30:336-341
  • 7.Basso C, Boschello M, Perrone C, Mecenero A, Cera A, Bicego D, et al. An echocardiographic survey of primary school children for bicuspid aortic valve. Am J Cardiol. 2004;93:661-663
  • 8.Datta BN, Bhusnurmath B, Khattri HN, Sapru RP, Bidwai PS, Wahi PL. Anatomically isolated aortic valve disease. Morphologic study of 100 cases at autopsy. Jpn Heart J. 1988;29:661-670
  • 9.Gross L. So-called congenital bicuspid aortic valve. Arch Pathol. 1937;23:350-362
  • lO.Pauperip HM, Azevedo AC, Ferreira CS. The aortic valve with two leaflets-a study in 2,000 autopsies. Cardiol Young. 1999;9:488-498
  • ll.Wauchope GM. The clinical importance of variations in the number of cusps forming the aortic and pulmonary valves. Quart J Med. 1928;21:383-399
  • 12.Larson EW, Edwards WD. Risk factors for aortic dissection: a necropsy study of 161 cases. Am J Cardiol. 1984; 53:849-855
  • 13.Roberts WC. The congenially bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol. 1970;26:72-83
  • 14.Anabwani GM, Bonhoeffer P. Prevalence of heart disease in school children in rural Kenya using colour-flow echocardiography. East Afr Med J. 1996;73:215-217
  • 15.Gupta I, Gupta ML, Parihar A, Gupta CD.Epidemiology of rheumatic and congenital heart diseases in school children. J Indian Med Assoc. 1992;90:57-59
  • 16.Stephensen SS, Sigfüsson G, Eirîksson H, Sverrisson JT, Torfason B, Haraldsson A,et al. Congenital cardiac malformations in Iceland from 1990 through 1999. Cardiol Young. 2004; 14:396-401
  • 17.Steinberger J, Moller JH, Berry JM, Sinaiko AR. Echocardiographic diagnosis of heart disease in apparently healthy adolescents. Pediatrics. 2000;1054:815-818
  • 18.Tutar E, Ekici F, Atalay S, Nacar N. The prevalence of bicuspid aortic valve in newborns by echocardiographic screening. Am Heart J. 2005;150:513-515
  • 19.Movahed MR, Hepner AD, Ahmadi-Kashani M. Echocardiographic prevalence of bicuspid aortic valve in the population. Heart Lung Circ. 2006;15:297-299
  • 2O.Alegret JM, Palomares R, Duran I, Vernis JM, Palazon O. Effect of age on valvular dysfunction and aortic dilatation in patients with a bicuspid aortic valve. Rev Esp Cardiol. 2006;59:503-506
  • 21. Hahn RT, Roman MJ, Mogtader AH, Devereux RB. Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves. J Am Coll Cardiol 1992;19:283-288
  • 22.Pachulski RT, Chan KL. Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography. Br Heart J. 1993;69:237-240
  • 23.Sabet HY, Edwards WD, Tazelaar HD, Daly RC. Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2715 additional cases. Mayo Clin Proc. 1999;74:14-26
  • 24.Bauer M, Pasic M, Schaffarzyk R, Siniawski H, Knollmann F, Meyer R, et al. Reduction aortoplasty for dilatation of the ascending aorta in patients with bicuspid aortic valve. Ann Thorac Surg. 2002;73:720-724
  • 25.Cecconi M, Nistri S, Quarti A, Manfrin M, Colonna PL, Molini E, et al. Aortic dilatation in patients with bicuspid aortic valve. J Cardiovasc Med (Hagerstown). 2006;7:ll-20
  • 26.Cripe L, Andelfinger G, Martin U, Shooner K, Benson DW. Bicuspid aortic valve is heritable. J Am Coll Cardiol. 2004;44:138-143
  • 27.Atalay S, Özme Ş, Özkutlu S, Özer Ş, Balcı S. Recurrence risks of congenital heart disease. Türkiye Klinikleri J Pediatr. 1993;4:188-91
  • 28.Güler N, Özkara C. Aortic Regurgitation. Türkiye Klinikleri J Int Med Sci. 2006;15:35-38
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Murat Sucu This is me

Vedat Davutoğlu This is me

Orhan Özer This is me

Osman Başpınar This is me

Mehmet Aksoy This is me

Metin Kılıç This is me

Publication Date March 1, 2009
Published in Issue Year 2009 Volume: 15 Issue: 2

Cite

APA Sucu, M., Davutoğlu, V., Özer, O., Başpınar, O., et al. (2009). Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı. Gaziantep Medical Journal, 15(2), 15-18.
AMA Sucu M, Davutoğlu V, Özer O, Başpınar O, Aksoy M, Kılıç M. Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı. Gaziantep Medical Journal. March 2009;15(2):15-18.
Chicago Sucu, Murat, Vedat Davutoğlu, Orhan Özer, Osman Başpınar, Mehmet Aksoy, and Metin Kılıç. “Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı”. Gaziantep Medical Journal 15, no. 2 (March 2009): 15-18.
EndNote Sucu M, Davutoğlu V, Özer O, Başpınar O, Aksoy M, Kılıç M (March 1, 2009) Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı. Gaziantep Medical Journal 15 2 15–18.
IEEE M. Sucu, V. Davutoğlu, O. Özer, O. Başpınar, M. Aksoy, and M. Kılıç, “Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı”, Gaziantep Medical Journal, vol. 15, no. 2, pp. 15–18, 2009.
ISNAD Sucu, Murat et al. “Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı”. Gaziantep Medical Journal 15/2 (March 2009), 15-18.
JAMA Sucu M, Davutoğlu V, Özer O, Başpınar O, Aksoy M, Kılıç M. Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı. Gaziantep Medical Journal. 2009;15:15–18.
MLA Sucu, Murat et al. “Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı”. Gaziantep Medical Journal, vol. 15, no. 2, 2009, pp. 15-18.
Vancouver Sucu M, Davutoğlu V, Özer O, Başpınar O, Aksoy M, Kılıç M. Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı. Gaziantep Medical Journal. 2009;15(2):15-8.