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Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı

Year 2011, Volume: 17 Issue: 1, 15 - 19, 01.02.2011

Abstract

Çocukluk çağı obezitesi halk sağlığını tehdit eden en sık hastalıklardan biri olarak kabul edilir. Obezite, koroner kalp hastalığı, hipertansiyon, dislipidemi, insülin direnci ve metabolik sendroma neden olan temel bozukluklardan biridir. Ayrıntılı klinik çalışmalarda çoğu klinik bulgu erişkin yaşta başlamasına rağmen çocukluk çağında başladığı gösterilmiştir. Bu çalışmanın amacı çocukluk çağı obezitesinde metabolik sendrom sıklığını belirlemektir. Obezite şekiayeti olan 8-16 yaş arasında 66 çocukta araştırma yapılmıştır. İnsülin direnci 33 hastada (%50), dislipidemi 49 hastada (%74) ve hipertansiyon 18 hastada (%27) bulunmuştur. Metabolik sendrom sıklığı 28 hastada %42 olarak belirlenmiştir. Sonuç olarak obez çocuklar arasında metabolik sendrom sıklığı oldukça yüksektir.

References

  • 1. Raine JN, Donaldson MDC, Gregory JW, Savage MO. Obesity. In, Practical Endocrinol and Diabetes in Children, United Kingdom: Blackwell Science, 2001. p.161-71.
  • 2. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arc Pediatr Adolesc Med 2003;157:821-7.
  • 3. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assesment is more reliable than the fasting glucose/insulin ratio and quantative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500-3.
  • 4. Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr 2004;145:445-51.
  • 5. Update on the 1987 task force report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adeloscents. Pediatrics 1996;98:649-58.
  • 6. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999;103:1175-82.
  • 7. Chen W, Bao W, Begum S, Elkasabany A, Srinivasan SR, Berenson GS. Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study. Diabetes 2000;49:1042-8.
  • 8. Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. Am J Cardiol 2002;90:3-7.
  • 9. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes 2002;51:204-9.
  • 10. Berenson GS, Srinivasan SR. Cardiovascular risk factors in youth with implications for aging: the Bogalusa Heart Study. Neurobiol Aging 2005;26:303-7.
  • 11. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003;107:1448-53.
  • 12. Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab 2004;89:108-13.
  • 13. Csabi G, Torok K, Jeges S, Molnar D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000;159:91-4.
  • 14. Galli-Tsinopoulou A, Karamouzis M, Nousia-Arvanitakis S. Insulin resistance and hyperinsulinemia in prepubertal obese children. J Pediatr Endocrinol Metab 2003;16:555-60.
  • 15. Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ. Isolated systolic hypertension, obesity and hyperkinetic hemodynamic states in children. J Pediatr 2002;140:660-6.
  • 16. Steinberger J, Moorehead C, Katch V, Rocchini AP. Relationship between insulin resistance and abnormal lipid profile in obese adolescents. J Pediatr 1995;126:690-5.
  • 17. Atabek ME, Pirgon O, Kurtoglu S. Prevalence of metabolic syndrome in obese Turkish children and adolescents. Diabetes Res Clin Pract 2006;72:315-21.
  • 18. Agirbasli M, Cakir S, Ozme S, Ciliv G. Metabolic syndrome in Turkish children and adolescents. Metabolism 2006;55:1002-6.
  • 19. Conwell L, Batch J. Oral glucose tolerance test in children and adolescents: positives and pitfalls. J Paediatr Child Health 2004;40:620-6.
  • 20. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802-10.
  • 21. Tresco B, Bueno G, Moreno LA, Garagorri JM, Bueno M. Insulin resistance and impaired glucose tolerance in obese children and adolescents. J Physiol Biochem 2003;59:217-23.

Insulin resistant and metabolic syndrome frequency in childhood obesity

Year 2011, Volume: 17 Issue: 1, 15 - 19, 01.02.2011

Abstract

Childhood obesity is considered as one of the most common illness threating public health. Obesity is one of the basic life threatening factor causing coronary heart diseases, hypertension, dyslipidemia, insulin resistance and metabolic syndrome. In detailed clinical studies it has been shown that this type of illness, which mostly showing clinical findings in adult age, is based in the childhood. The aim of this study was to evaluate the prevalence of metabolic syndrome in childhood obesity. Insulin resistance was found in 33 patients (50%); dyslipidemia in 49 patients (74%) and hypertension in 18 patients (27%). Metabolic syndrome was observed in 28 (42%) patients. As consequence, metabolic syndrome frequency was very high in obese children.

References

  • 1. Raine JN, Donaldson MDC, Gregory JW, Savage MO. Obesity. In, Practical Endocrinol and Diabetes in Children, United Kingdom: Blackwell Science, 2001. p.161-71.
  • 2. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arc Pediatr Adolesc Med 2003;157:821-7.
  • 3. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assesment is more reliable than the fasting glucose/insulin ratio and quantative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500-3.
  • 4. Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr 2004;145:445-51.
  • 5. Update on the 1987 task force report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adeloscents. Pediatrics 1996;98:649-58.
  • 6. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999;103:1175-82.
  • 7. Chen W, Bao W, Begum S, Elkasabany A, Srinivasan SR, Berenson GS. Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study. Diabetes 2000;49:1042-8.
  • 8. Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. Am J Cardiol 2002;90:3-7.
  • 9. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes 2002;51:204-9.
  • 10. Berenson GS, Srinivasan SR. Cardiovascular risk factors in youth with implications for aging: the Bogalusa Heart Study. Neurobiol Aging 2005;26:303-7.
  • 11. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003;107:1448-53.
  • 12. Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab 2004;89:108-13.
  • 13. Csabi G, Torok K, Jeges S, Molnar D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000;159:91-4.
  • 14. Galli-Tsinopoulou A, Karamouzis M, Nousia-Arvanitakis S. Insulin resistance and hyperinsulinemia in prepubertal obese children. J Pediatr Endocrinol Metab 2003;16:555-60.
  • 15. Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ. Isolated systolic hypertension, obesity and hyperkinetic hemodynamic states in children. J Pediatr 2002;140:660-6.
  • 16. Steinberger J, Moorehead C, Katch V, Rocchini AP. Relationship between insulin resistance and abnormal lipid profile in obese adolescents. J Pediatr 1995;126:690-5.
  • 17. Atabek ME, Pirgon O, Kurtoglu S. Prevalence of metabolic syndrome in obese Turkish children and adolescents. Diabetes Res Clin Pract 2006;72:315-21.
  • 18. Agirbasli M, Cakir S, Ozme S, Ciliv G. Metabolic syndrome in Turkish children and adolescents. Metabolism 2006;55:1002-6.
  • 19. Conwell L, Batch J. Oral glucose tolerance test in children and adolescents: positives and pitfalls. J Paediatr Child Health 2004;40:620-6.
  • 20. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802-10.
  • 21. Tresco B, Bueno G, Moreno LA, Garagorri JM, Bueno M. Insulin resistance and impaired glucose tolerance in obese children and adolescents. J Physiol Biochem 2003;59:217-23.
There are 21 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

M. Erkan Altuncu This is me

Yılmaz Kör This is me

Ahmet İrdem This is me

Osman Başpınar This is me

Mehmet Keskin This is me

Publication Date February 1, 2011
Published in Issue Year 2011 Volume: 17 Issue: 1

Cite

APA Altuncu, M. E., Kör, Y., İrdem, A., Başpınar, O., et al. (2011). Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı. Gaziantep Medical Journal, 17(1), 15-19.
AMA Altuncu ME, Kör Y, İrdem A, Başpınar O, Keskin M. Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı. Gaziantep Medical Journal. February 2011;17(1):15-19.
Chicago Altuncu, M. Erkan, Yılmaz Kör, Ahmet İrdem, Osman Başpınar, and Mehmet Keskin. “Obez çocuklarda insülin Direnci Ve Metabolik Sendrom sıklığı”. Gaziantep Medical Journal 17, no. 1 (February 2011): 15-19.
EndNote Altuncu ME, Kör Y, İrdem A, Başpınar O, Keskin M (February 1, 2011) Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı. Gaziantep Medical Journal 17 1 15–19.
IEEE M. E. Altuncu, Y. Kör, A. İrdem, O. Başpınar, and M. Keskin, “Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı”, Gaziantep Medical Journal, vol. 17, no. 1, pp. 15–19, 2011.
ISNAD Altuncu, M. Erkan et al. “Obez çocuklarda insülin Direnci Ve Metabolik Sendrom sıklığı”. Gaziantep Medical Journal 17/1 (February 2011), 15-19.
JAMA Altuncu ME, Kör Y, İrdem A, Başpınar O, Keskin M. Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı. Gaziantep Medical Journal. 2011;17:15–19.
MLA Altuncu, M. Erkan et al. “Obez çocuklarda insülin Direnci Ve Metabolik Sendrom sıklığı”. Gaziantep Medical Journal, vol. 17, no. 1, 2011, pp. 15-19.
Vancouver Altuncu ME, Kör Y, İrdem A, Başpınar O, Keskin M. Obez çocuklarda insülin direnci ve metabolik sendrom sıklığı. Gaziantep Medical Journal. 2011;17(1):15-9.