The effect of the glucose-insulin-potassium solution on the p-wave dispersion of the heart failure patients

Year 2012, Volume: 18 Issue: 2, 85 - 89, 01.03.2012

Süleyman Ercan Muhammed Oylumlu Mustafa Oylumlu Serdar Soydinç Vedat Davutoğlu

Abstract

Atrial fibrillation (AF) has adverse effects on the disease prognosis and the functional capacity during heart failure. P wave dispersion has been considered as one of the most important parameters predicting the development of AF. It is known that glucose-insulinpotassium (GIK) infusion has favorable metabolic and hemodynamic effects. The aim of our study is to investigate the effects of GIK infusion on P wave dispersion in patients with heart failure. In our study, 30 patients with the diagnosis of heart failure and a low left ventricular ejection fraction (EF0.05). In Group I, P wave dispersion measured after GIK infusion was 13 ± 6.5. In group II, P wave dispersion measured after 0.9% NaCl solution infusion were 20.4±6.4. P wave dispersion was found significantly lower in patients administrated GİK infusion (p=0.001). According to the present study, we showed that the P wave dispersion which predicts AF was significantly lower in the patients treated with GIK than in the control group.

Keywords

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Kalp yetersizliği hastalarında glukoz-insülin-potasyum infüzyonunun p dalga dispersiyonu üzerine etkisi

Abstract

Kalp yetersizliği seyrinde izlenilen atriyal fibrilasyon (AF) prognoz ve fonksiyonel kapasite üzerinde olumsuz etkilere neden olmaktadır. P dalga dispersiyonu AF gelişimini predikte eden önemli parametrelerden biri olarak kabul görmüştür. Glukoz-insülinpotasyum (GİK) infüzyonunun hemodinamik ve metabolik olumlu etkileri bilinmektedir. Çalışmamızda kalp yetersizliği olan hastalarda GİK infüzyonunun P dalga dispersiyonu üzerine olan etkisi araştırıldı. Çalışmamıza kalp yetersizliği ve düşük sol ventrikül ejeksiyon fraksiyonu (EF0.05) hesaplandı. Grup I’de GİK infüzyonu sonrasında ölçülen P dalga dispersiyonu 13±6.5 hesaplandı. Grup II’de ise verilen %0.9 NaCl solüsyonu sonrasında P dalga dispersiyonu 20.4±6.4 olarak hesaplandı. Her iki grubun çalışma sonrası hesaplanan P dalga dispersiyonunda önemli istatistiksel fark bulundu (p=0.001) ve GİK alan grupta P dalga dispersiyonu önemli ölçüde kısalmaktaydı. Çalışmamıza göre GİK infüzyonu alan hastalarda AF’nin prediktör olan P dalga dispersiyonunun kontrol grubuna göre anlamlı olarak azaldığı gösterildi.

Keywords

Glukoz-insülin-potasyum, kalp yetersizliği, P dalga dispersiyonu

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