genel tıp derg Genel Tıp Dergisi 2602-3741 Selcuk University Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1 Can Ümmügülsüm Konya Eğitim ve Araştırma Hastanesi, Biyokimya Laboratuvarı, Konya 12 01 2016 26 4 121 126 Copyright © 1990, Genel Tıp Dergisi 1990 Genel Tıp Dergisi

Oksidatif stres fazla oksidant bileşiğin yapılması ve antioksidant koruma mekanizmasının azlığı sonucu oluşarak doku hasarlarına yol açar. Oksidatif stres sonucu oluşan okside-düşük dansiteli lipoprotein oxidized low-density lipoprotein ox-LDL , reseptörü lektin benzeri ox-LDL reseptör-1 lectin-like receptor for ox-LDL-1 LOX-1 ’e bağlanır. ox-LDL ve LOX-1 endotel disfonksiyonu, monosit adezyonu, düz kas hücre proliferasyon, migrasyon ve apoptozis, yağ hücre yapımı ve trombosit aktivasyonu ile ilgili mekanizmalarda görev alır. ox-LDL, ateroskleroz, diabetes mellitus, yaşlanma, metabolik sendrom, kardiovasküler, ve serebrovasküler, böbrek ve karaciğer hastalıklarında artarak hastalıkların patogenezlerinde aktif rol alır. Bu derlemede, ox-LDL ve reseptörü LOX-1 etkileri incelenmiştir

Oxidative stress as a result of excess oxidant compounds and lack of antioxidant protection mechanism may occur and can lead to tissue damage. Oxidized low-density lipoprotein ox-LDL caused by oxidative stress binds to lectin-like for receptor ox-LDL receptor-1 LOX-1 . ox-LDL and LOX-1 is involved in endothelial dysfunction, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation. ox-LDL increases in atherosclerosis, diabetes, aging, metabolic syndrome, cardiovascular, and cerebrovascular disease kidney and liver and takes an active role in in the pathogenesis of several diseases. In this review, we focused ox-LDL and ıts receptor LOX-1 effects

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