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            <front>

                <journal-meta>
                                                                <journal-id>genel tıp derg</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Genel Tıp Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2602-3741</issn>
                                                                                            <publisher>
                    <publisher-name>Selcuk University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                                                                                                                                            <title-group>
                                                                                                                        <article-title>Arı sokmalarına karşı oluşan reaksiyonlar</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Reactions caused by bee stings</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Gezer</surname>
                                    <given-names>Deniz</given-names>
                                </name>
                                                                    <aff>Çankırı Devlet Hastanesi Dahiliye</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Şenel</surname>
                                    <given-names>Engin</given-names>
                                </name>
                                                                    <aff>Çankırı Devlet Hastanesi, Deri  ve Zührevi Hastalıklar Kliniği, Aksu Mah. Öğretmenler Sokak  18200, Çankırı.</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Süslü</surname>
                                    <given-names>İclal</given-names>
                                </name>
                                                                    <aff>Abidinpaşa Teknik ve Endüstri Meslek Lisesi, Ankara</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20120101">
                    <day>01</day>
                    <month>01</month>
                    <year>2012</year>
                </pub-date>
                                        <volume>22</volume>
                                        <issue>3</issue>
                                        <fpage>102</fpage>
                                        <lpage>108</lpage>
                        
                        <history>
                                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 1990, Genel Tıp Dergisi</copyright-statement>
                    <copyright-year>1990</copyright-year>
                    <copyright-holder>Genel Tıp Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Arı venomlarına karşı gelişen reaksiyonlar, ciddi sonuçlarının olabilmesi nedeniyle önemli bir sağlık sorunu  oluşturmaktadır. Reaksiyonlar arı sokmasının olduğu bölgede, lokal veya sistemik olarak ortaya çıkabilir.  Reaksiyonlar IgE bağımlı veya IgE bağımsız mekanizmalara bağlı olabilir. Bu derlemede, arı sokmalarında oluşan  lezyonların ve reaksiyonların sınıflandırılması, tanı ve tedavi yöntemleri sunulmaktadır</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>Reactions to hymenoptera venoms are major health problems because of their serious consequences. Reactions  to hymenoptera venoms can develop locally or systemically and may be mediated by IgE-dependent or non-IgE- dependent mechanisms. In this review we aimed to discuss the classification, diagnosis and the management of  the lesions and reactions caused by hymenoptera venomhypersensitivity</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Arı venomu</kwd>
                                                    <kwd>   venom aşırı duyarlılığı</kwd>
                                                    <kwd>   venom hipersensitivitesi</kwd>
                                                    <kwd>   alerjik reaksiyonlar</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>hymenoptera venom</kwd>
                                                    <kwd>   venom hypersensitivity</kwd>
                                                    <kwd>   allergic reactions</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Schwartz MW, Pool WR, Bieber AL. Mojave rattlesnake (Crotalus scutulatus scutulatus) venom: enzyme activities and purification 1984;22:327-38. ester hydrolases. Toxicon</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Navarro LA, Pelaez A, de la Torre F, Tenias Burillo JM, Megias J, Martinez I. Epidemiological factors on hymenoptera venom allergy in a Spanish adult population. J Investig Allergol Clin Immunol 2004;14:134-41.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Fernandez J, Blanca M, Soriano V, Sanchez J, Juarez C. Epidemiological study of the prevalence of allergic reactions to Hymenoptera in a rural population in the Mediterranean area. Clin Exp Allergy 1999;29:1069-74.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Golden DB. Insect sting allergy and venom immunotherapy: A model and a mystery. J Allergy Clin Immunol 2005;115:439-47.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Golden DB, Marsh DG, Kagey-Sobotka A, et al. Epidemiology of insect venom sensitivity. JAMA 1989;262: 240-4. Arı sokmalarındaki reaksiyonlar, Gezer ve ark.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Ebo DG, Hagendorens MM, Stevens WJ. Hymenoptera
venom allergy. Expert Rev Clin Immunol 2005;1:169-75.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">. Johansson S G, Hourihane J O, Bousquet J, et al. A revised
nomenclature for allergy. An EAACI position statement fromthe EAACI nomenclature task force. Allergy 2001;56: 813-24.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">. Incorvaia C, Mauro M, Pastorello E A. Hymenoptera stings in
conscripts. Allergy 1997;52:680-1.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Barnard JH. Studies of 400 Hymenoptera sting deaths in the
United States. J Allergy Clin Immunol 1973;52:259-64.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">. Sin B. Allerjik Hastalıklar ve Bronşial Astma. İstanbul: Özlem
Grafik: 1998.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">. Aytekin AM. Arılar ve yaban arıları. Astım Allerji İmmünol
2006;4:5-9.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Kalyoncu AF. Honey allergy and rhinitis in Ankara, Turkey.
Allergy 1997;52:876-7.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">. Severino M, Bonadonna P, Passalacqua G. Large local
reactions from stinging insects: from epidemiology to
management. Curr Opin Allergy Clin Immunol 2009;9:334-7.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">. Bilo BM, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink J
N. Diagnosis of Hymenoptera venom allergy. Allergy
2005;60:1339-49.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">. Antonicelli L, Bilo MB, Bonifazi F. Epidemiology of
Hymenoptera allergy. Curr Opin Allergy Clin Immunol
2002;2:341-6.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">. Golden DB, Kagey-Sobotka A, Norman PS, Hamilton RG,
Lichtenstein LM. Insect sting allergy with negative venom
skin test responses. J Allergy Clin Immunol 2001;107:897-
901.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">. Golden DB. Insect sting anaphylaxis. Immunol Allergy Clin
North Am 2007;27:261-72.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">. Hogan AD, Schwartz LB. Markers of mast cell degranulation.
Methods 1997;13:43-52.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">. Reisman RE. Insect stings. N Engl J Med 1994;331:523-7.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">. Muller U. Insect sting allergy-clinical aspects, diagnosis and
therapy. Wien Med Wochenschr 1989;139:150-6.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">. Sasvary T, Muller U. Fatalities from insect stings in
Switzerland 1978 to 1987. Schweiz Med Wochenschr</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">. Kettner A, Hughes G J, Frutiger S, et al. Api m 6: a new bee
venom allergen. J Allergy Clin Immunol 2001;107:914-20.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">. Zhang R, Meleg-Smith S, Batuman V. Acute tubulointerstitial
nephritis after wasp stings. Am J Kidney Dis 2001;38:33.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">. Pucci S, Antonicelli L, Bilo MB, Garritani MS, Bonifazi F.
Shortness of interval between two stings as risk factor for
developing Hymenoptera venom allergy. Allergy 1994;49:
894-6.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">. Valentine M D, Schuberth K C, Kagey-Sobotka A, et al. The
value of immunotherapy with venom in children with allergy
to insect stings. N Engl J Med 1990;323:1601-3.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">. Engel T, Heinig J H, Weeke E R. Prognosis of patients
reacting with urticaria to insect sting. Results of an in-hospital
sting challenge. Allergy 1988: 43: 289-293.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Annila IT, Annila PA, Morsky P. Risk assessment in
determining systemic reactivity to honeybee stings in
beekeepers. Ann Allergy Asthma Immunol 1997;78:473-7.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">. Lockey RF, Turkeltaub PC, Baird-Warren IA. The
Hymenoptera venom study I, 1979-1982: Demographics and
history-sting data. J Allergy Clin Immunol 1988;82:370-81.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">. Lantner R, Reisman RE. Clinical and immunologic features
and subsequent course of patients with severe insect-sting
anaphylaxis. J Allergy Clin Immunol 1989;84:900-6.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">. Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio
FJ, Lichtenstein LM. A controlled trial of immunotherapy in
insect hypersensitivity. N Engl J Med 1978;299:157-61.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">. Ludolph-Hauser D, Rueff F, Fries C, Schopf P, Przybilla B.
Constitutively raised serum concentrations of mast-cell
tryptase and severe anaphylactic reactions to Hymenoptera
stings. Lancet 2001;357:361-2.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">. Muller UR. Hymenoptera venom hypersensitivity: An update.
Clin Exp Allergy 1998;28:4-6.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">Muller U, Helbling A, Berchtold E. Immunotherapy with
honeybee venom and yellow jacket venom is different
regarding efficacy and safety. J Allergy Clin Immunol
1992;89:529-35.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">. Chiang BL. Molecular mechanisms of allergen-specific
immunotherapy for atopic diseases. Zhonghua Min Guo Xiao
Er Ke Yi Xue Hui Za Zhi 1998;39:293-6.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">Kowalski ML, Jutel M. Mechanisms of specific
immunotherapy of allergic diseases. Allergy 1998;53:485-92.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J,
Saloga J. Insect venom immunotherapy induces interleukin-10
production and a Th2-to-Th1 shift, and changes surface
marker expression in venom-allergic subjects. Eur J Immunol
1997;27:1131-9.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">Akdis CA, Blesken T, Akdis M, Wuthrich B, Blaser K. Role
of interleukin 10 in specific immunotherapy. J Clin Invest
1998;102:98-106.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">Yang X. Does allergen immunotherapy alter the natural course
of allergic disorders? Drugs 2001;61:365-74.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">Jutel M, Akdis M, Budak F, et al. IL-10 and TGF-beta
cooperate in the regulatory T cell response to mucosal
allergens in normal immunity and specific immunotherapy.
Eur J Immunol 2003:33:1205-14.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">King TP, Spangfort MD. Structure and biology of stinging
insect venom allergens. Int Arch Allergy Immunol
2000;123:99-106.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">Muller UR. Epidemiology of insect sting allergy. Monogr
Allergy 1993;31:131-46.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">Moffitt JE, Golden D B, Reisman R E, et al. Stinging insect
hypersensitivity: a practice parameter update. J Allergy Clin
Immunol 2004;114:869-86.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
