genel tıp derg Genel Tıp Dergisi 2602-3741 Selcuk University 10.54005/geneltip.1301387 Clinical Sciences Klinik Tıp Bilimleri Vitamin D Level of Children with Diabetic Ketoacidosis in Pediatric Intensive Care Unit Pediatrik Yoğun Bakım Ünitesindeki Diyabetik Ketoasidozlu Çocukların D Vitamini Düzeylerinin Değerlendirilmesi https://orcid.org/0000-0001-7377-4718 Uysal Yazici Mutlu Gazi University Faculty of Medicine Department Of Pediatric Intensive Care https://orcid.org/0000-0001-8138-3514 Ozel Erhan University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital https://orcid.org/0000-0003-2005-7082 Torun Emine Gulsah University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital https://orcid.org/0000-0002-4164-5089 Savaş Erdeve Şenay .; University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital https://orcid.org/0000-0003-3974-2872 Çetinkaya Semra University of Health Sciences, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital 10 25 2023 33 5 523 526 05 24 2023 08 17 2023 Copyright © 1990, Genel Tıp Dergisi 1990 Genel Tıp Dergisi

Aims: Vitamin D deficiency is a risk factor for autoimmune diseases such as diabetes mellitus. This study aimed to investigate the association between Diabetic ketoacidosis (DKA) and vitamin D levels and the impact of vitamin D on the duration of DKA and pediatric intensive care unit length of stay in Turkish pediatric patients.Methods: The study was a retrospective study conducted between January 2014 and March 2018. The study population was children under 18 admitted to the pediatric intensive care unit (PICU) with DKA. Results: The study included 130 patients, 51.5% of them were females. We found vitamin D deficiency in 39.2%(n=51) and vitamin D insufficiency in 33.1% (n=43) of the patients. Most of the patients with severe acidosis had low vitamin D levels (44/59) and % 45.8 of them (27/59) had vitamin D deficiency. Duration of diabetic ketoacidosis, length of pediatric intensive care unit stay, and hospitalization stay were longer in patients with low vitamin D levels but were not statistically significant. Conclusions: This study is the first study evaluating the association between vitamin D and diabetic ketoacidosis in Turkey. Although there is no association between vitamin D deficiency and the duration of diabetic ketoacidosis and the severity of acidosis, vitamin D deficiency is substantially common in patients with diabetic ketoacidosis.

Amaç: Vitamin D eksikliği, diabetes mellitus gibi otoimmün hastalıkların gelişimi için bir risk faktörüdür. Bu çalışma, çocuk hastalarda Diyabetik ketoasidoz (DKA) ile serum D vitamini düzeyleri arasındaki ilişkiyi ve D vitamininin DKA süresi ve çocuk yoğun bakım ünitesinde kalış süresine etkisini araştırmayı amaçlamıştır.Metot: Çalışma, Ocak 2014-Mart 2018 tarihleri arasında yürütülen retrospektif bir çalışmadır. Çalışma popülasyonu DKA tanısı ile çocuk yoğun bakım ünitemizde (ÇYBÜ) takip edilen 18 yaş altı çocuklar oluşturmaktadır.Bulgular: Çalışmaya 130 hasta dahil edildi ve bunların %51.5'i kadındı. Hastaların %39.2'sinde (n=51) D vitamini eksikliği, %33.1'inde (n=43) D vitamini yetersizliği olduğunu bulundu. Şiddetli asidozlu hastaların çoğunda D vitamini düzeyi düşük (44/59) ve % 45.8'inde (27/59) D vitamini eksikliği vardı. D vitamini düzeyi düşük olan hastalarda diyabetik ketoasidoz süresi, pediatrik yoğun bakımda kalış süresi ve hastanede kalış süresi daha uzundu ancak istatistiksel olarak anlamlı değildi.Sonuç: Bu çalışma, Türkiye'de D vitamini ile diyabetik ketoasidoz ilişkisini değerlendiren ilk çalışmadır. D vitamini eksikliği ile diyabetik ketoasidoz süresi ve asidozun şiddeti arasında bir ilişki olmamasına rağmen, diyabetik ketoasidozlu hastalarda D vitamini eksikliği oldukça yaygındır.

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