genel tıp derg Genel Tıp Dergisi 2602-3741 Selcuk University 10.54005/geneltip.996818 Clinical Sciences Klinik Tıp Bilimleri A New Prognostic Factor in Patients with Acute Tonsillitis and Peritonsillar Abscess; C-Reactive Protein / Albumin Ratio Akut Tonsillit ve Peritonsiller Apseli Hastalarda Yeni Bir Prognostik Faktör; C-Reaktif Protein / Albumin Oranı Yüksel Fatih Konya Şehir Hastanesi, Kulak burun Boğaz Hastalıkları Özsöz Ekrem Konya Şehir Hastanesi, Kulak burun Boğaz Hastalıkları Aydın İsa Konya Şehir Hastanesi, Kulak burun Boğaz Hastalıkları Kahraman Mehmet Erkan Konya Şehir Hastanesi, Kulak burun Boğaz Hastalıkları 09 20 2021 31 3 270 275 01 04 2021 02 26 2021 Copyright © 1990, Genel Tıp Dergisi 1990 Genel Tıp Dergisi

Background: Peritonsillar abscess is a serious infectious disease of the tonsil tissue. Treatment usually requires both medical and surgical approaches to relieve symptoms. Recently, some tests such as C-reactive protein (CRP) and albumin in addition to clinical follow-up are thought to be additional inflammatory monitoring markers.Aim: The aim of this study is to investigate whether the CRP/albumin ratio can be used to predict conversion to peritonsillar abscess in patients with acute tonsillitis.Patients and methods: This study was conducted by retrospectively evauating the CRP / albumin ratios of 138 patients with acute tonsillitis and 106 patients with peritonsillar abcess who were admitted to our clinic between January 2003 and June 2020. Leukocyte count, neutrophil count, lymphocyte count, C – reactive protein, albumin and neutrophil – lymphocyte ratio values were simultaneously analyzed and compared between groups.Results: CRP / albumin ratio levels were significantly higher in the peritonsillar abscess group than in the acute tonsillitis group (p < 0.05). There was no significant difference between peritonsillar abscess and acute tonsillitis group in neutrophil-lymphocyte ratio levels (p > 0.05). While the rate of albumin was found to be significantly lower in the peritonsillar abscess group, the lymphocyte count was found to be significantly higher. There was no significant difference between the groups in terms of white blood cell count, neutrophil count, C-reactive protein values (p > 0.05).Conclusion: The CRP / albumin ratio is thought to be an easy-to-measure, reproducible, non-invasive prognostic score that can be used to predict peritonsillar abscess formation in patients with acute tonsillitis.

Amaç: Peritonsiller apse, tonsil dokusunun ciddi bir enfeksiyon hastalığıdır. Tedavisinde genellikle semptomları hafifletmek için hem tıbbi hem de cerrahi yaklaşımlar gerekir. Son zamanlarda, klinik takibe ek olarak C-reaktif protein (CRP) ve albumin gibi bazı parametrelerin, ek enflamatuar izleme belirteçleri olduğu düşünülmektedir. Bu çalışmanın amacı akut tonsillitli hastaların peritonsiller apseye dönüşümünü tahmin etmek için CRP / albumin oranının kullanılıp kullanılamayacağını araştırmaktır.Hastalar ve Yöntem: Bu çalışma Ocak 2003 ile Haziran 2020 tarihleri arasında Konya Şehir Hastanesi Kulak Burun Boğaz Kliniği’nde yatış yapılarak takip edilen 138 akut tonsillitli ve 106 peritonsiller apseli hastanın retrospektif olarak CRP/albumin oranları değerlendirilerek gerçekleştirildi. Aynı zamanda lökosit, nötrofil ve lenfosit sayıları ile CRP, albümin ve nötrofil / lenfosit (NLO) oranı değerleri de retrospektif olarak analiz edildi ve hasta grupları arasında karşılaştırıldı.Bulgular: CRP / albumin oranı düzeyleri peritonsiller apse grubunda, akut tonsillit grubuna göre anlamlı olarak daha yüksekti (p<0.05). Peritonsiller apse ile akut tonsillit grubu arasında NLO düzeylerinde anlamlı bir fark yoktu (p>0.05). Peritonsiller apse grubunda albümin oranı anlamlı olarak düşük bulunurken (p<0.05). lenfosit sayısı anlamlı oranda yüksek bulundu. (p<0.05). Beyaz küre sayısı, nötrofil sayısı, C-reaktif protein değerlerinde gruplar arasında anlamlı olarak fark yoktu (p>0.05).Sonuç: CRP / albümin oranının, akut tonsillitli hastalarda peritonsiler apse dönüşümünü tahmin etmek için kullanılabilecek ölçülmesi kolay, tekrarlanabilir, invaziv olmayan ve inflamasyona dayalı prognostik bir skor olabileceği düşünülmektedir.

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