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Nötrofil-Lenfosit Oranlarının, Platelet Belirteçlerinin ve Sodyum Düzeyinin Febril Nöbetler ile İlişkisi

Year 2021, Volume: 31 Issue: 3, 216 - 220, 20.09.2021
https://doi.org/10.54005/geneltip.996495

Abstract

Amaç: Çocuk acil servise febril nöbet ile başvuran hastaların laboratuvar parametrelerini belirlemek ve bunların basit ve komplike nöbet ayrımındaki önemini göstermektir.

Gereç ve Yöntem: Aralık 2019-Mart 2020 tarihleri arasında Adana Şehir Hastanesi Çocuk Acil Bölümü’ne febril nöbet ile başvuran hastaların başvurudan sonraki ilk bir saat içindeki nötrofil-lenfosit oranları, platelet değerleri ve sodyum düzeyleri incelendi.

Bulgular: 138 basit ve komplike febril nöbet hastası çalışmaya alındı. 111’i (% 80,4) basit febril nöbet 27’si (% 19,5) komplike febril nöbetti. Nötrofil/lenfosit oranları ile Mean Platelet volüm/platelet oranları arasında basit ve komplike nöbet ayrım bakımından anlamlı bir farklılık saptanmadı (p> 0,05). Ancak febril nöbet ile başvuran hastaların % 65,2’de hiponatremi olup basit ve komplike nöbetler bakımından anlamlı farklılık mevcuttu (p:0,006). Tekrarlayan nöbet riski yönünden farklılık saptanmadı (p> 0,05).

Sonuç: Hiponatreminin febril nöbete yatkınlık sağlayan bir neden olabileceği düşünüldü.

References

  • Natsume J, Hamano SI, Iyoda K, et al. New guidelines for management of febrile seizures in Japan. Brain Dev 2017;39:2.
  • Hesdorffer DC, Benn EK, Bagiella E, et al. Distribution of febrile seizure duration and associations with development. Ann Neurol 2011;70:93.
  • Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37:126.
  • Fana LL, Wanga YJ, Nana CJ, et al. Neutrophil-lymphocyte ratio is associated with all-cause mortality among critically ill patients with acute kidney injury. Clinica Chimica Acta 2019;490:207-13.
  • Yavuz S, Ece A. Mean platelet volume as an indicator of disease activity in juvenile SLE. Clin Rheumatol 2014;33:637-41.
  • Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2.
  • Hugen CA, Oudesluys-Murphy AM, Hop WC. Serum sodium levels and probability of recurrent febrile convulsions. Eur. J. Pediatr 1995:154;403-5.
  • Kiviranta T, Airaksinen EM. Low sodium levels in serum are associated with subsequent febrile seizures, Acta Paediatr 1995:84;1372-4.
  • Vezzani A, Moneta D, Richichi C, et al. Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 2002;5:30-5.
  • Dube C, Vezzani A, Behrens M, Bartfai T, Baram TZ. Interleukin-1β contributes to the generation of experimental febrile seizures. Ann Neurol 2005;57:152-5.
  • Özkale M, Erol İ, Özkale Y. Association between platelet indices and febrile seizures in children. J Cukurova Med 2016;41:695-701.
  • Yiğit Y, Yılmaz S, Akdoğan A, Halhalli HC, Ozbek AE, Gencer EG. The role of neutrophil-lymphocyte ratio and red blood cell distribution width in the classification of febrile seizures. Europ Rev for Med and Pharmacol Sciences 2017;21:554-9.
  • Göksügür SB, Kabakuş N, Bekdaş M. Neutrophil-to-lymphocyte ratio and red blood cell distribution width is a practical predictor for differentiation of febrile seizure types. Europ Rev for Med and Pharmacol Sciences 2014;18: 3380-5.
  • Liu Z, Li X, Zhang M, et al. The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure. Scientific reports 2018;8:15123.
  • Dilber B, Arslan EA, Şahin S, Esenülkü G, Kart PÖ, Cansu A. Febril nöbette hiponatreminin önemi. JCP 2020;18:53-62.
  • Suryawanshi M, Madavi D, Gandhi P. Assocıatıon of febrıle seızure wıth hyponatremıa a prospectıve study. Paediatrics 2019;8:8160.
  • Zifman E, Alehan F, Menascu S, et al. Clinical Characterization of Gastroenteritis-Related Seizures in Children: Impact of Fever and Serum Sodium Levels. Journal of Child Neurology 2011;26:1397-400.
  • Heydarian F, Ashrafzadeh F, Kam S. Simple febrile seizure: the role of serum sodium levels in prediction of seizure recurrence during the first 24 hours. Iran J Child Neurol 2009;3:31-4.
  • Maksikharin A, Prommalikit O. Serum sodium levels do not predict recurrence of febrile seizures within 24 hours. Ped Int child health 2015;35:44-6.
  • Kubotaa J, Higurashib N, Hiranob D, et al. Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures. Journ of the Neurol Sci 2020;411:116682.

The Association of Neutrophil-Lymphocyte Ratios, Platelet Markers and Sodium Level with Febrile Seizures

Year 2021, Volume: 31 Issue: 3, 216 - 220, 20.09.2021
https://doi.org/10.54005/geneltip.996495

Abstract

Aim: The aim of this study was to determine laboratory parameters of the patients with febrile seizure who was applied to the pediatric emergency department and to show their importance in the distinction of the simple and complicated febrile seizure.

Material and Methods: The neutrophil-lymphocyte ratios, platelet levels and sodium values of the ​​patients who were applied to the Adana City Hospital Training and Research Hospital pediatric emergency department with febrile seizure between December 2019-March 2020 were examined with in the first hour.

Results: 138 simple and complicated febrile seizure patients were included in the study. 111 (% 80,4) were simple febrile seizures and 27 (% 19,5) were complicated febrile seizures. We did not find any significant difference between neutrophil/lymphocyte ratios and mean platelet volume / platelet ratios in the distinction of simple and complicated febrile seizure (p> 0,05). However, % 65,2 of the patients presenting with febrile seizures had hyponatremia and there was a significant difference between the simple and complicated febrile seizures (p:0, 006). There was no difference in terms of seizure recurrence risk (p> 0,05).

Conclusions: Hyponatremia was thought to be an underlying cause in the etiology of acute febrile seizure.

References

  • Natsume J, Hamano SI, Iyoda K, et al. New guidelines for management of febrile seizures in Japan. Brain Dev 2017;39:2.
  • Hesdorffer DC, Benn EK, Bagiella E, et al. Distribution of febrile seizure duration and associations with development. Ann Neurol 2011;70:93.
  • Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37:126.
  • Fana LL, Wanga YJ, Nana CJ, et al. Neutrophil-lymphocyte ratio is associated with all-cause mortality among critically ill patients with acute kidney injury. Clinica Chimica Acta 2019;490:207-13.
  • Yavuz S, Ece A. Mean platelet volume as an indicator of disease activity in juvenile SLE. Clin Rheumatol 2014;33:637-41.
  • Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2.
  • Hugen CA, Oudesluys-Murphy AM, Hop WC. Serum sodium levels and probability of recurrent febrile convulsions. Eur. J. Pediatr 1995:154;403-5.
  • Kiviranta T, Airaksinen EM. Low sodium levels in serum are associated with subsequent febrile seizures, Acta Paediatr 1995:84;1372-4.
  • Vezzani A, Moneta D, Richichi C, et al. Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 2002;5:30-5.
  • Dube C, Vezzani A, Behrens M, Bartfai T, Baram TZ. Interleukin-1β contributes to the generation of experimental febrile seizures. Ann Neurol 2005;57:152-5.
  • Özkale M, Erol İ, Özkale Y. Association between platelet indices and febrile seizures in children. J Cukurova Med 2016;41:695-701.
  • Yiğit Y, Yılmaz S, Akdoğan A, Halhalli HC, Ozbek AE, Gencer EG. The role of neutrophil-lymphocyte ratio and red blood cell distribution width in the classification of febrile seizures. Europ Rev for Med and Pharmacol Sciences 2017;21:554-9.
  • Göksügür SB, Kabakuş N, Bekdaş M. Neutrophil-to-lymphocyte ratio and red blood cell distribution width is a practical predictor for differentiation of febrile seizure types. Europ Rev for Med and Pharmacol Sciences 2014;18: 3380-5.
  • Liu Z, Li X, Zhang M, et al. The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure. Scientific reports 2018;8:15123.
  • Dilber B, Arslan EA, Şahin S, Esenülkü G, Kart PÖ, Cansu A. Febril nöbette hiponatreminin önemi. JCP 2020;18:53-62.
  • Suryawanshi M, Madavi D, Gandhi P. Assocıatıon of febrıle seızure wıth hyponatremıa a prospectıve study. Paediatrics 2019;8:8160.
  • Zifman E, Alehan F, Menascu S, et al. Clinical Characterization of Gastroenteritis-Related Seizures in Children: Impact of Fever and Serum Sodium Levels. Journal of Child Neurology 2011;26:1397-400.
  • Heydarian F, Ashrafzadeh F, Kam S. Simple febrile seizure: the role of serum sodium levels in prediction of seizure recurrence during the first 24 hours. Iran J Child Neurol 2009;3:31-4.
  • Maksikharin A, Prommalikit O. Serum sodium levels do not predict recurrence of febrile seizures within 24 hours. Ped Int child health 2015;35:44-6.
  • Kubotaa J, Higurashib N, Hiranob D, et al. Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures. Journ of the Neurol Sci 2020;411:116682.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Original Article
Authors

Esra Sarıgeçili This is me

Habibe Koç Uçar This is me

Sinem Sarı Gökay This is me

Publication Date September 20, 2021
Submission Date June 3, 2020
Published in Issue Year 2021 Volume: 31 Issue: 3

Cite

Vancouver Sarıgeçili E, Koç Uçar H, Sarı Gökay S. Nötrofil-Lenfosit Oranlarının, Platelet Belirteçlerinin ve Sodyum Düzeyinin Febril Nöbetler ile İlişkisi. Genel Tıp Derg. 2021;31(3):216-20.

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