Helikobakter pilori pozitif bireylerde endotel disfonksi serum CRP ve B12 vitamin düzeyleri arasındaki ilişki

Year 2013, Volume: 23 Issue: 3, 81 - 86, 01.01.2013

Şeref Alpsoy Mustafa Oran Rafet Mete Aydın Akyüz Dursun Cayan Akkoyun Birol Topcu Hasan Değirmenci

Abstract

Amaç: Çalışmanın amacı Helicobacter pylori HP seropozitif ve negatif bireylerde, endotel fonksiyon parametrelerini, C- reaktif protein CRP ve vitamin B12 düzeylerini ölçmek ve endotel fonksiyon parametreleri ile CRP ve vitamin B12 arasında ilişki olup olmadığını ortaya koymaktı. Materyal ve metod: Dispeptik yakınmaları olan110 kişide HP immünglobulin G antikor düzeyleri, CRP ve B12 vitamini düzeyleri ölçüldü. Brakiyal arter endotel-bağımlı akım aracılı vazodilatasyon ve endotel bağımsız nitrogliserin bağlı vazodilatasyon yanıtı ölçümleri yüksek frekanslı ultrasonografik görüntüleme ile yapıldı. Bulgular: HP immünglobulin G antikoru 70 kişide pozitif, 40 kişide ise negatifti. HP negatif bireylere kıyasla HP pozitif bireylerde brakiyal arter akım aracılı dilatasyon yanıtı azalmış, CRP düzeyi yüksek, vitamin B12 düzeyi ise düşüktü. HP pozitif bireylerde akım aracılı vazodilatasyon yanıtı ile yaş ve CRP arasında ters yönlü ilişki varken vitamin B12 ile aynı yönde ilişki vardı. Endotel bağımsız vazodilatasyon her iki grupta da benzerdi. Sonuç: Kronik HP enfeksiyonunda, sistemik ve vasküler inflamasyon artışı ve vitamin B12 eksikliği endotel disfonksiyonu gelişmesinde etkili olabilir

Keywords

B12 vitamin eksikliği, brakiyal arter, C reaktif protein, endotel, Helicobacter pylori

The relationship between endothelial dysfunction and serum levels of CRP and vitamin B12 in Helicobacter pylori-positive subjects

Abstract

Objectives: The aim of the study was to measure the endothelial function parameters and serum levels of C-reactive protein CRP and vitamin B12 in Helicobacter pylori HP -seropositive and negative individuals and to investigate the relationship between the endothelial function parameters and CRP and vitamin B12 levels. Materials and methods: The serum levels of immunoglobulin G antibodies to HP, CRP, and vitamin B12 were determined in 110 subjects who had dyspeptic complaints. High-frequency ultrasonog- raphic imaging of the brachial artery was used to determine endothelium-dependent flow-mediated vasodilation [FMD] and endo- thelium-independent nitroglycerin-induced vasodilation. Results: HP antibody was positive in 70 subjects and negative in 40 sub- jects. Compared to the HP negative subjects, HP-positive individuals had decreased brachial artery FMD, elevated levels of CRP and decreased level of vitamin B12. FMD was negatively correlated with age and CRP and positively correlated with vitamin B12 in HP positive subjects. Endothelium independent vasodilation was similar in both groups. Conclusion: Increasing in systemic and vascular inflammation, and vitamin B12 deficiency may be effective in the development of endothelial dysfunction in chronic HP infection

Keywords

Vitamin B12 deficiency, brachial artery, C-reactive protein, endothelium, Helicobacter pylori

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