Çocuklarda Periferik Kan Kök Hücrelerin Toplanması ve Transplantasyonu: Tek Merkez Deneyimi

Year 2024, Volume: 34 Issue: 3, 301 - 305, 30.06.2024

Cengiz Zeybek Orhan Gürsel Ahmet Bolat İbrahim Eker Erman Atas Ahmet Emin Kürekçi

https://doi.org/10.54005/geneltip.1386100

Abstract

Amaç: Hematopoetik kök hücre kaynağı olarak periferik kan kök hücreleri hem malign hem de non-malign hastalıklarda giderek daha çok kullanılmaktadır. Ancak çocuklarda özellikle de küçük çocuklarda erişkinlerden farklı olarak periferik kan kök hücre toplanmasında damar yolu ve ekstrakorporeal set volümü gibi zorluklarla karşılaşılabilmektedir.
Yöntem: Biz bu çalışmada Kasım 2016 ile Eylül 2023 tarihleri arasında, kendi merkezimizde periferik kan kök hücre toplaması ve transplantasyonu yaptığımız 63 çocuk hastayı sunuyoruz.
Bulgular: Aferez seansları sırasında çocukların ortalama yaş ve kiloları sırasıyla 10.25 ve 34 kg idi. Toplam 63 periferik kan kök hücre toplanması ve transplantasyonu işleminin 48’i otolog, 15’i allojeneik idi. Her aferez seansında elde edilen ortalama kök hücre sayısı 2.6 x 106 CD34+ hücre/kg (0.6-9.66) idi. Toplam 63 hasta ve donordan 4’üne multipl aferez seansları gerekti. Aferez seansları sonrası önemli bir yan etki gözlenmedi.
Sonuç: Deneyimli ellerde, çocuklarda periferik kan kök hücre toplaması ve transplantasyonunun en az erişkinler kadar güvenli ve etkili olduğunu gözlemledik.

Keywords

kemik iliği nakli, hematopoetik kök hücre nakli, periferik kök hücre nakli, çocuklar

Project Number

Etik Kurul No 2023/233

Collection and Transplantation of Peripheral Blood Stem Cells in Children: A Single-Center Experience

Abstract

Background/Aims: As a source of hematopoietic stem cells, peripheral blood stem cells have been used more frequently in both malignant and non-malignant diseases. There are some difficulties in the collection of PBSC from children compared to adults such as vascular access and, extracorporeal circuit volume, especially in small children.
Methods: In this study, we present our experience in 63 children who underwent peripheral blood stem cell collection and transplantation between November 2016 and September 2023.
Results: The median age and weight of the children at the time of apheresis procedures were 10.25 years and 34 kg, respectively. Of 63 peripheral blood stem cell collection and transplantations, 48 were autologous and 15 were allogeneic. The median cell yield per apheresis procedure was 2.6 x 106 CD34+ cells/kg (0.6-9.66). Four of the total 63 patients and donors required multiple apheresis procedures. No significant side effects were observed after apheresis procedures.
Conclusions: We observed that in experienced hands, peripheral blood stem cell collection and transplantation in children is at least as safe and effective as in adults.

Keywords

bone marrow transplantation, hematopoietic stem cell transplantation, peripheral stem cell transplantation, children

Project Number

Etik Kurul No 2023/233

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