Öz
Şizofreni, dünya çapında 24
milyondan fazla erişkini etkilemektedir. Şizofreni bireysel, sosyal ve ekonomik
yük ile ilişkilendirilmektedir. Bu yükün çoğu şizofreni hastalarının
işlevselliklerindeki bozulmayla ilişkilidir. Şizofreni hastaları okul başarısı,
iş bulma ve çalışmayı sürdürme, sosyal ilişki kurma, bağımsız yaşama ve günlük
ihtiyaçlarını karşılama konusunda zorluk çekmektedirler. Bilişsel defisitler,
şizofreninin ana semptomlarındandır ve işlevsellikte bozulmayla güçlü bir
şekilde ilişkilidir. Bu derlemede güncel bilgiler doğrultusunda şizofreni
hastalarında gözlenen nörobilişsel bozulma ve bunun işlevsellikle ilişkisinin
gözden geçirilmesi amaçlanmıştır.
Anahtar Kelimeler
Kaynakça
- 1. Green MF, What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry, 1996. 153(3): p. 321-30.
- 2. Özen NE, Yüksel N, Kognitif Nörobilimler, Nobel Tıp Kitabevleri, Ankara, 2010.
- 3. Lepage M, Bodnar M, and Bowie CR, Neurocognition: clinical and functional outcomes in schizophrenia. Can J Psychiatry, 2014. 59(1): p. 5-12.
- 4. Heinrichs RW and Zakzanis KK, Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology, 1998. 12(3): p. 426-45.
- 5. Keefe RSE, Eesley CE, Neurocognitive Impairments. Textbook of Schizophrenia. 2006: The American Psychiatric Publishing.
- 6. Bora E and Murray RM, Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophr Bull, 2014. 40(4): p. 744-55.
- 7. Bortolato B, et al., Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses. Neuropsychiatr Dis Treat, 2015. 11: p. 3111-25.
- 8. Brewer WJ, et al., Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophr Bull, 2006. 32(3): p. 538-55.
- 9. Addington J and Barbato M, The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis. Epidemiol Psychiatr Sci, 2012. 21(4): p. 335-42.
- 10. Ceylan ME, Araştırma ve Klinik Uygulamada Biyolojik Psikiyatri - Şizofreni 1. Cilt. 2009: İstanbul. p. 75-831.
Öz
Schizophrenia affects more
than 24 million adults worldwide. It is associated with personal, social, and
economic burden. Most of its burden is due to the functional disabilities from
which patients with schizophrenia suffer. Patients with schizophrenia have
difficulty succeeding at school, obtaining or maintaining a job, having social relationships,
living independently and taking care of their basic daily needs. Cognitive
deficits are considered as core features of schizophrenia and have been found
to be strongly associated with patients’ functional disabilities. This review
aimed to review the neurocognitive impairments and their relation to
functionality in patients with schizophrenia.
Anahtar Kelimeler
Kaynakça
- 1. Green MF, What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry, 1996. 153(3): p. 321-30.
- 2. Özen NE, Yüksel N, Kognitif Nörobilimler, Nobel Tıp Kitabevleri, Ankara, 2010.
- 3. Lepage M, Bodnar M, and Bowie CR, Neurocognition: clinical and functional outcomes in schizophrenia. Can J Psychiatry, 2014. 59(1): p. 5-12.
- 4. Heinrichs RW and Zakzanis KK, Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology, 1998. 12(3): p. 426-45.
- 5. Keefe RSE, Eesley CE, Neurocognitive Impairments. Textbook of Schizophrenia. 2006: The American Psychiatric Publishing.
- 6. Bora E and Murray RM, Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophr Bull, 2014. 40(4): p. 744-55.
- 7. Bortolato B, et al., Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses. Neuropsychiatr Dis Treat, 2015. 11: p. 3111-25.
- 8. Brewer WJ, et al., Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophr Bull, 2006. 32(3): p. 538-55.
- 9. Addington J and Barbato M, The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis. Epidemiol Psychiatr Sci, 2012. 21(4): p. 335-42.
- 10. Ceylan ME, Araştırma ve Klinik Uygulamada Biyolojik Psikiyatri - Şizofreni 1. Cilt. 2009: İstanbul. p. 75-831.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 17 Mayıs 2018 |
| Kabul Tarihi | 19 Mart 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 8 Sayı: 2 |