Histopathological Effect of Bendiocarb on Small Intestine Tissues of Rats: Role of Vitamins C and E

Year 2019, Volume: 32 Issue: 2, 402 - 407, 01.06.2019

Fatma Gokce Apaydın Hatice Baş Suna Kalender Caglar Adıgüzel Yusuf Kalender

Abstract

Bendiocarb is a carbamate insecticide which causes general toxic effects on mammalian. This study aimed to examine the possible ameliorative roles vitamins E and C and their combination against effect of bendiocarb small intestine toxicity in rats. For this purpose, forty-eight adult albino male rats were divided like: vitamin E, control, vitamin C, vitamins (C and E), bendiocarb, bendiocarb+vitamin E, bendiocarb+vitamin C, and bendiocarb+vitamin C+vitamin E groups. After four weeks of treatment small intestine tissues were examined for histopathological alterations. Bendiocarb induced toxicity on small intestine tissues, vitamins had not protective effects of this toxicity

Keywords

Bendiocarb, Vitamin C, Vitamin E, Small intestine, Histopathology

References

• [1] Jardim, A.N.O., Brito, A.P., Donkersgoed, G., Boon, P.E., and Caldasa, E.D., “Dietary cumulative acute risk assessment of organophosphorus, carbamates and pyrethroids insecticides for the Brazilian population”, Food Chem. Toxicol. 112: 108-117, (2018).
• [2] Hayes, W.J., Laws, E.R., Handbook of Pesticide Toxicology, Academic Press, New York. p. 303. (1991).
• [3] Siqueira, A., Rodrigues, K.B.A., Gonçalves-Júnior, V., Calefi, A.S., Fukushima, A.R., Cuevas, S.E.C., Spinosa,H.S., and Maiorka, P.C., “Exhumation of Wistar rats experimentally exposed to the carbamate pesticides aldicarb and carbofuran: A pathological and toxicological study”, Exp. Toxicol. Pathol. 68: 307–314, (2016).
• [4] Capcarova, M., Petrovova, E., Flesarova, S., Dankova, M., Massanyi, P., and Danko, J., “Bendiocarbamate induced alterations in selected parameters of rabbit homeostasis after experimental peroral administration”, Pestic. Biochem. Physiol. 8: 213–218, (2010).
• [5] Petrovova, E., Massanyi, P., Capcarova, M., Zivcak J., and Stodola, L., “Structural alterations in rabbit spleen after bendiocarb administration”, J. Environ. Sci. Health, Part B 46: 788–792, (2011).
• [6] Flesarova, S., Lukac, N., Danko, J., and Massanyi, P., Bendiocarbamate induced structural alterations in rabbit thymus after experimental peroral administration”, J. Environ. Sci. Heal. Part B. 42: 329–334, (2007).
• [7] Smulders, C.J., Bueters, T.J., Van Kleef, R.G., and Vijverberg, H.P., “Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase”, Toxicol. Appl. Pharmacol. 193: 139–146 (2003).
• [8] Jokanovic´, M., “Medical treatment of acute poisoning with organophosphorus and carbamate pesticides” Toxicol. Lett. 190: 107–115 (2009).
• [9] Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and biochemical alterations inrat liver and preventive role of vitamins C and E”, Environ. Toxicol. Pharmacol. 49: 148–155, (2017).
• [10] Uzun, F.G., Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin”, Food Chem. Toxicol. 55: 549-556, (2013).
• [11] El-Demerdash, F., “Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminium” J.Trace Elem. Med.. Biol. 18: 113-121 (2004).
• [12] Kalender, S., Apaydın, F.G., Uzunhisarcıklı, M., and Aslanturk, A., “Protective Role of Sodium Selenite and Vitamin E Against Rat Erythrocytes Induced by Mercury Chloride”, GU J. Sci. 27(4): 1123-112 (2014).
• [13] Aslanturk, A., Kalender, S., Uzunhisarcikli, M., and Kalender, Y., “Effects of methidathion on antioxidant enzyme activities and malondialdehyde level in midgut tissues of Lymantria dispar (Lepidoptera) larvae”, J. Entomol. Res. Soc. 13: 27-38, (2011).
• [14] Buyukguzel, E., Kalender, Y., “Penicillin-induced oxidative stress: effects on antioxidative response of midgut tissues in larval instars of G. mellonella”, J. Econ. Entomol. 100 (5): 1533-1541, (2007).
• [15] Shirpoor, A., Barmaki, H., Ansari, M.K., lkhanizadeh, B., and Barmaki, H., “Protective effect of vitamin E against ethanol-induced small intestine damage in rats” Biomed. Pharmacother. 78: 150–155 (2016).
• [16] Baş, H., Kalender, S., Karaboduk, H., and Apaydın, FG., “The effects on antioxidant enzyme systems in rat brain tissues of lead nitrate and mercury chloride”, GU J. Sci. 28(2): 169-174, (2015).
• [17] Demir, F., Uzun, F.G., Durak, D., Kalender, Y., “Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin”, Pestic. Biochem. Physiol. 99: 77-81 (2011). [18] Mezouar, D., Merzouk, H., Merzouk, A.S., Merzouk, S.A., Belarbi, B., Narce, M., “In vitro effects of vitamins C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell function and redox status in type 1 diabetic pregnant women”, Placenta, 42:114-121, (2016).
• [19] Chappell, L.C., Seed, P.T., Kelly, F.J., Briley, A., Hunt, B.J., Charnock-Jones, S., Mallet, A., Poston, L., “Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function”, Am. J. Obstet. Gynecol. 187: 777-784, (2002).