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EVALUATION OF ARTIFICIAL SWEETENERS IN TERMS OF HEALTHY NUTRITION AND HALAL FOOD

Year 2024, Volume: 6 Issue: 1, 44 - 58, 30.06.2024
https://doi.org/10.51973/head.1471043

Abstract

Today, artificial sweeteners are widely used in food production to reduce calorie intake, lose weight, and maintain a healthy diet. Artificial sweeteners stimulate hormones with their sweet taste content, some reach the microbiota without being digested, and also act as a substrate for gut bacteria. By using this effect by intestinal bacteria, it may leads to a decrease or increase in short-chain fatty acid (SCFA) production by changing the ratio of intestinal microbiota. Recent studies suggest that consumption of artificial sweeteners may induce dysbiosis of the gut microbiota and lead to the development of type 2 diabetes mellitus (T2DM) and glucose intolerance in healthy individuals. Considering that the research supporting the consumption and safety of artificial sweeteners is not sufficient, and that existing studies give conflicting results, so it is inevitable to reevaluate the healthiness and halalness of the issue. As a result, this study aimed to evaluate artificial sweeteners used in various foods in terms of healthy nutrition and halal food production.

References

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YAPAY TATLANDIRICILARIN SAĞLIKLI BESLENME VE HELAL GIDA AÇISINDAN DEĞERLENDİRİLMESİ

Year 2024, Volume: 6 Issue: 1, 44 - 58, 30.06.2024
https://doi.org/10.51973/head.1471043

Abstract

Günümüzde, kalori alımını azaltmak ve kilo vermek amacıyla gıdalarda yapay tatlandırıcılar yaygın olarak kullanılmaktadır. Yiyeceklerde bulunan yapay tatlandırıcılar, tatlı tat içeriği ile hormonların uyarılmasını sağlar, bazıları sindirilmeden mikrobiyotaya ulaşır ve bağırsak bakterilerinin substratı olarak da işlev görür. Bu etkisi bağırsak bakterileri tarafından kullanılarak kısa zincirli yağ asidi (KZYA) üretimi artırılabildiği gibi bağırsak bakteri oranlarını değiştirerek KZYA üretiminin azalmasına da yol açabilmektedir. Son çalışmalar, yapay tatlandırıcı tüketiminin intestinal mikrobiyota disbiyozunu (bağırsak ekosistemini bozan sağlıksız bağırsak florası oluşumu) indükleyebileceğini ve sağlıklı bireylerde tip 2 diyabetes mellitus (T2DM) gelişimine ve glukoz intoleransına neden olabileceğini göstermektedir. Yapay tatlandırıcı tüketimi ve güvenliğini destekleyen araştırmaların henüz yeterli düzeyde olmadığı ve mevcut çalışmaların da birbirinden farklı sonuçlar verdiği göz önüne alınarak konunun sağlık ve helallik boyutunun yeniden değerlendirilmesi gerektiği açıktır. Sonuç olarak bu çalışmada, çeşitli gıdalarda kullanılan yapay tatlandırıcılar ve bunların sağlıklı beslenme açısından önemi ve helallik durumunun değerlendirilmesi amaçlanmıştır.

References

  • Abou-Donia, M. B., El-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E., & Schiffman, S. S. (2008). Splenda alters gut microflora and increases intestinal P-glycoprotein and cytochrome P-450 in male rats. Journal of Toxicology and Environmental Health - Part A: Current Issues, 71(21), 1415–1429. https://doi.org/10.1080/15287390802328630
  • Ahmad, S. Y., Friel, J., & Mackay, D. (2020). The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: Secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients, 12(11), 1–16. https://doi.org/10.3390/nu12113408
  • Azeez, OH, Alkass, SY ve Persike, DS (2019). Sıçanlarda uzun süreli sakarin tüketimi ve artan obezite, diyabet, karaciğer fonksiyon bozukluğu ve böbrek yetmezliği riski. Tıp , 55 (10), 681.
  • Basson, A. R., Rodriguez-Palacios, A., & Cominelli, F. (2021). Artificial Sweeteners: History and New Concepts on Inflammation. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.746247
  • Baumgartner, R., Forteza, M. J., & Ketelhuth, D. F. J. (2019). The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis. Cytokine, 122. https://doi.org/10.1016/j.cyto.2017.09.004
  • Beloborodova, N., Bairamov, I., Olenin, A., Shubina, V., Teplova, V., & Fedotcheva, N. (2012). Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils. Journal of Biomedical Science, 19(1). https://doi.org/10.1186/1423-0127-19-89
  • Bernardo, W. M., Simões, R. S., Buzzini, R. F., Nunes, V. M., & Glina, F. P. A. (2016). Adverse effects of the consumption of artificial sweeteners - Systematic review. Revista Da Associacao Medica Brasileira, 62(2), 120–122. https://doi.org/10.1590/1806-9282.62.02.120
  • Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017a). Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice. Frontiers in Physiology, 8(JUL). https://doi.org/10.3389/fphys.2017.00487
  • Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017b). The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS ONE, 12(6). https://doi.org/10.1371/journal.pone.0178426
  • Bian, X., Tu, P., Chi, L., Gao, B., Ru, H., & Lu, K. (2017). Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food and Chemical Toxicology, 107, 530–539. https://doi.org/10.1016/j.fct.2017.04.045
  • Büyüközer, H. K. (2013). Yeni Dünya Düzeni ve Helal gıda, 2. Baskı, Erkam Matbaası, İstanbul.
  • Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., Waget, A., Delmée, E., Cousin, B., Sulpice, T., Chamontin, B., Ferrières, J., Tanti, J. F., Gibson, G. R., Casteilla, L., Burcelin, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761–1772. https://doi.org/10.2337/db06-1491
  • Carocho, M., Morales, P., & Ferreira, I. C. F. R. (2017). Sweeteners as food additives in the XXI century: A review of what is known, and what is to come. Food and Chemical Toxicology, 107, 302–317. https://doi.org/10.1016/j.fct.2017.06.046
  • Castro-Muñoz, R., Correa-Delgado, M., Córdova-Almeida, R., Lara-Nava, D., Chávez-Muñoz, M., Velásquez-Chávez, V. F., Hernández-Torres, C. E., Gontarek-Castro, E., & Ahmad, M. Z. (2022). Natural sweeteners: Sources, extraction and current uses in foods and food industries. Food Chemistry, 370. https://doi.org/10.1016/j.foodchem.2021.130991
  • Chattopadhyay, S., Raychaudhuri, U., & Chakraborty, R. (2014). Artificial sweeteners–a review. Journal of Food Science and Technology, 51(4), 611–621.
  • Chi, L., Bian, X., Gao, B., Tu, P., Lai, Y., Ru, H., & Lu, K. (2018). Effects of the artificial sweetener neotame on the gut microbiome and fecal metabolites in mice. Molecules, 23(2). https://doi.org/10.3390/molecules23020367
  • Daly, K., Darby, A. C., & Shirazi-Beechey, S. P. (2016). Low calorie sweeteners and gut microbiota. Physiology and Behavior, 164, 494–500. https://doi.org/10.1016/j.physbeh.2016.03.014
  • EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). (2013). Scientific Opinion on the re‐evaluation of aspartame (E 951) as a food additive. Efsa Journal, 11(12), 3496.
  • FDA. (2018). Additional Information about High-Intensity Sweeteners Permitted for Use in Food in the United States. US Food & Drug Administration, 1–7.
  • Fernández, J., Redondo-Blanco, S., Gutiérrez-del-Río, I., Miguélez, E. M., Villar, C. J., & Lombó, F. (2016). Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review. Journal of Functional Foods, 25, 511–522. https://doi.org/10.1016/j.jff.2016.06.032
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There are 58 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Review articles
Authors

Ömer Faruk Mızrak 0000-0002-0389-5626

Publication Date June 30, 2024
Submission Date April 19, 2024
Acceptance Date June 27, 2024
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

APA Mızrak, Ö. F. (2024). YAPAY TATLANDIRICILARIN SAĞLIKLI BESLENME VE HELAL GIDA AÇISINDAN DEĞERLENDİRİLMESİ. Helal Ve Etik Araştırmalar Dergisi, 6(1), 44-58. https://doi.org/10.51973/head.1471043

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