hjbc

Hacettepe Journal of Biology and Chemistry

2687-475X 2687-475X

Hacettepe University

The Bioinformatic and Expression Analysis of PSMD4 Gene

Aydoğan Türkoğlu

Sümeyye

BALIKESIR UNIVERSITY, FACULTY OF SCIENCE AND LETTERS, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS Güler

Gizem

BALIKESIR UNIVERSITY, FACULTY OF SCIENCE AND LETTERS, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS Köçkar

Feray

BALIKESIR UNIVERSITY, FACULTY OF SCIENCE AND LETTERS, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS

09 01 2018

46 3 329 336 08 21 2017 07 31 2018

1972

Hacettepe Journal of Biology and Chemistry

26S proteasome non-ATPase subunit 4 (PSMD4) that has a molecular weight of 41 kDa is included onchromosome 1 (1q21.3). PSMD4 protein is a subunit of the 19S regulatory region in the 26S proteasome.The proteasome breaks down proteins that are not needed or non-functional in the cell. We have limited dataabout the regulation of this gene in the literature. In our research, changes in the mRNA and protein levelsof the PSMD4 gene were investigated in different cancer cell lines (prostate, breast, colon, cervix, hepatoma,osteosarcoma and pancreas) and a normal cell (human vein endothelial cell). The highest expression of PSMD4gene was seen in HUVEC and PC-3 cells. Bioinformatic analysis was also performed on PSMD4 protein fordifferent species namely human, mouse and rat. Our Bioinformatic analyses showed that first 250 nucleotidesare much conserved in all three species.

PSMD4 cancer cell lines bioinformatics

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