One-pot Three-component Synthesis of Novel Quinazoline-4-carboxylic Acid and Derivatives

Year 2020, Volume: 48 Issue: 3, 283 - 290, 15.06.2020

Derviş Gök

https://doi.org/10.15671/hjbc.736847

Cited By: 1

Abstract

Amonyum asetat ve benzaldehit ile isatinin hidrolizinden elde edilen (2-amino-fenil)-okso-asetik asit sodyum tuzunun aynı ortamda üç bileşenli reaksiyonundan 2-fenil-kinazolin-4-karboksilik asit (2) sentezlendi. Daha sonra 2 ve çeşitli alkoller arasındaki reaksiyonlarından bazı yeni kinazolin-ester türevleri (3a-d) elde edildi. Son olarak 2 bileşiği ile SOCl2’nin reaksiyonundan elde edilen 2-fenil-kinazolin-4-karbonil klorür ve çeşitli aminlerin reaksiyonundan kinazolin-amit türevleri (5a-e) sentezlendi. Sentezlenen bileşiklerin yapıları 1H NMR, 13C NMR, IR, kütle spektrometri analiz metotları tarafından doğrulandı.

Keywords

Quinazoline-4-carboxylic acid, isatin, ester, amide

Supporting Institution

Dumlupinar University Technology Research Fund

Project Number

2015/24

Thanks

We are grateful to the Dumlupinar University Technology Research Fund for the financial support of this study through project number of 2015/24.

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