Year 2021, Volume 49 , Issue 1, Pages 107 - 116 2021-01-01

DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine

Ceyda İÇSEL [1]


The binding interactions of cis-[Pd(sac)2(PPh2Et)2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies. The Pd(II) complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA. These experimental findings were supported by molecular docking studies. The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.
Paladyum(II), Sakkarinat, Antikansr aktivite, DNA/HSA bağlanma
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Primary Language en
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-2717-2430
Author: Ceyda İÇSEL (Primary Author)
Institution: BURSA ULUDAĞ ÜNİVERSİTESİ
Country: Turkey


Thanks The assistance of Dr. Buse Cevatemre (Koç Üniversity) in the cytotoxicity experiments is greatly acknowledged.
Dates

Publication Date : January 1, 2021

Bibtex @research article { hjbc836685, journal = {Hacettepe Journal of Biology and Chemistry}, issn = {2687-475X}, eissn = {2687-475X}, address = {Hacettepe Üniversitesi Fen Fakültesi, 06532, Beytepe/ ANKARA/ TÜRKİYE}, publisher = {Hacettepe University}, year = {2021}, volume = {49}, pages = {107 - 116}, doi = {10.15671/hjbc.836685}, title = {DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine}, key = {cite}, author = {İçsel, Ceyda} }
APA İçsel, C . (2021). DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine . Hacettepe Journal of Biology and Chemistry , 49 (1) , 107-116 . DOI: 10.15671/hjbc.836685
MLA İçsel, C . "DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine" . Hacettepe Journal of Biology and Chemistry 49 (2021 ): 107-116 <https://dergipark.org.tr/en/pub/hjbc/issue/58116/836685>
Chicago İçsel, C . "DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine". Hacettepe Journal of Biology and Chemistry 49 (2021 ): 107-116
RIS TY - JOUR T1 - DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine AU - Ceyda İçsel Y1 - 2021 PY - 2021 N1 - doi: 10.15671/hjbc.836685 DO - 10.15671/hjbc.836685 T2 - Hacettepe Journal of Biology and Chemistry JF - Journal JO - JOR SP - 107 EP - 116 VL - 49 IS - 1 SN - 2687-475X-2687-475X M3 - doi: 10.15671/hjbc.836685 UR - https://doi.org/10.15671/hjbc.836685 Y2 - 2020 ER -
EndNote %0 Hacettepe Journal of Biology and Chemistry DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine %A Ceyda İçsel %T DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine %D 2021 %J Hacettepe Journal of Biology and Chemistry %P 2687-475X-2687-475X %V 49 %N 1 %R doi: 10.15671/hjbc.836685 %U 10.15671/hjbc.836685
ISNAD İçsel, Ceyda . "DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine". Hacettepe Journal of Biology and Chemistry 49 / 1 (January 2021): 107-116 . https://doi.org/10.15671/hjbc.836685
AMA İçsel C . DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine. HJBC. 2021; 49(1): 107-116.
Vancouver İçsel C . DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine. Hacettepe Journal of Biology and Chemistry. 2021; 49(1): 107-116.
IEEE C. İçsel , "DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine", Hacettepe Journal of Biology and Chemistry, vol. 49, no. 1, pp. 107-116, Jan. 2021, doi:10.15671/hjbc.836685