Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats

Year 2007, Volume: 35 Issue: 1, 25 - 30, 01.01.2007

Ayşegül Akbay Yarpuzlu Yeşim Uğur Ayşegül Nazikoğlu Esin Asan İlkay Yildiz

Abstract

Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team. Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 . Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

Keywords

AIDS, HIV-RT inhibitor, 2-phenoxymethyl-5-chlorobenzimidazole, Kidney, rat, renal tubules, dimethylsulfoxide

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