Effects of Conformation and Molecular Weight on The Surface Energy and Mucoadhesion Properties of Calcium Alginate Gels

Year 2011, Volume: 39 Issue: 4, 371 - 378, 01.12.2011

Elif Dikicier Murat Şen

Abstract

In this study, the effects of the ratio of guluronic acid G to mannuronic acid M G/M and molecular weight of sodium alginate on the mucoadhesion and surface energy g properties were investigated. Sodium alginate fractions were prepared by radiation induced degradation and calcium alginate gels were prepared in the form of three-dimensional structure by using an in-situ gelling method. In order to determine the free energy of bioadhesion, the contact angles of paraffin, ethylene glycol and water on the surface of gels were measured. Based on the contact angles, the g components of the Liftshitz-van der Waals and the Lewis acid base interactions were calculated. It was found that CaAlg gels would lead to a thermodynamically favorable bioadhesion process, a decrease in the molecular weight of sodium alginate could increase the bioadhesion of CaAlg polymers, and that the bioadhesion of these gels was independent of G/M.

Keywords

Alginate, bioadhesion, gluronic acid / mannuronic acid ratio, gelation

Konformasyon ve Molekül Ağırlığının Kalsiyum Aljinat Jellerinin Yüzey Enerji ve Mukoz Yapışma Özellikleri Üzerindeki Etkisi

Abstract

Bmukoz yapışma ve yüzey enerjisi g özellikleri üzerindeki etkisi incelenmiştir. sodyum aljinat fraksiyonları u çalışmada, guluronik asitin G mannuronik asite M oranının G/M ve sodyum aljinatın molekül ağırlığının

Keywords

Aljinat, biyoyapışma, guluronik asit/mannuronik asit oranı, jelleşme

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